1HXS
 
 | | CRYSTAL STRUCTURE OF MAHONEY STRAIN OF POLIOVIRUS AT 2.2A RESOLUTION | | 分子名称: | GENOME POLYPROTEIN, COAT PROTEIN VP1, COAT PROTEIN VP2, ... | | 著者 | Miller, S.T, Hogle, J.M, Filman, D.J. | | 登録日 | 2001-01-16 | | 公開日 | 2002-01-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Ab initio phasing of high-symmetry macromolecular complexes: successful phasing of authentic poliovirus data to 3.0 A resolution.
J.Mol.Biol., 307, 2001
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1NG7
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1PO1
 | | POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R80633, AN INHIBITOR OF VIRAL REPLICATION | | 分子名称: | (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | | 著者 | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | | 登録日 | 1997-01-08 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Ligand-induced conformational changes in poliovirus-antiviral drug complexes.
Acta Crystallogr.,Sect.D, 53, 1997
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1NN8
 | | CryoEM structure of poliovirus receptor bound to poliovirus | | 分子名称: | MYRISTIC ACID, coat protein VP1, coat protein VP2, ... | | 著者 | He, Y, Mueller, S, Chipman, P.R, Bator, C.M, Peng, X, Bowman, V.D, Mukhopadhyay, S, Wimmer, E, Kuhn, R.J, Rossmann, M.G. | | 登録日 | 2003-01-13 | | 公開日 | 2004-01-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (15 Å) | | 主引用文献 | Complexes of poliovirus serotypes with their common cellular receptor, CD155
J.Virol., 77, 2003
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1POV
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1PO2
 | | POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION | | 分子名称: | (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | | 著者 | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | | 登録日 | 1997-01-08 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Ligand-induced conformational changes in poliovirus-antiviral drug complexes.
Acta Crystallogr.,Sect.D, 53, 1997
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1AR9
 | | P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y | | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | | 登録日 | 1997-08-11 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects.
Nat.Struct.Biol., 4, 1997
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1AL2
 | | P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT V1160I | | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | | 登録日 | 1997-06-09 | | 公開日 | 1997-11-19 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects.
Nat.Struct.Biol., 4, 1997
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1AR7
 | | P1/MAHONEY POLIOVIRUS, DOUBLE MUTANT P1095S + H2142Y | | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | | 登録日 | 1997-08-11 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects.
Nat.Struct.Biol., 4, 1997
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1AR8
 | | P1/MAHONEY POLIOVIRUS, MUTANT P1095S | | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | | 登録日 | 1997-08-11 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects.
Nat.Struct.Biol., 4, 1997
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1ASJ
 | | P1/MAHONEY POLIOVIRUS, AT CRYOGENIC TEMPERATURE | | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | | 登録日 | 1997-08-11 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects.
Nat.Struct.Biol., 4, 1997
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1AR6
 | | P1/MAHONEY POLIOVIRUS, DOUBLE MUTANT V1160I +P1095S | | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | | 登録日 | 1997-08-11 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects.
Nat.Struct.Biol., 4, 1997
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1RA7
 | | Poliovirus Polymerase with GTP | | 分子名称: | ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein | | 著者 | Thompson, A.A, Peersen, O.B. | | 登録日 | 2003-10-31 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase.
Embo J., 23, 2004
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1RAJ
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1RDR
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1RA6
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1TQL
 | | POLIOVIRUS POLYMERASE G1A MUTANT | | 分子名称: | ACETIC ACID, RNA-directed RNA polymerase | | 著者 | Thompson, A.A, Peersen, O.B. | | 登録日 | 2004-06-17 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
Embo J., 23, 2004
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1VBD
 | | POLIOVIRUS (TYPE 1, MAHONEY STRAIN) COMPLEXED WITH R78206 | | 分子名称: | (METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | | 著者 | Grant, R.A, Hiremath, C.N, Filman, D.J, Syed, R, Andries, K, Hogle, J.M. | | 登録日 | 1996-01-02 | | 公開日 | 1996-07-11 | | 最終更新日 | 2023-04-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
Curr.Biol., 4, 1994
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6XBU
 | | polymerase domain of polymerase-theta | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*TP*CP*AP*TP*TP*G)-3'), DNA polymerase theta, ... | | 著者 | Chen, X, Pomerantz, R, Zhao, J. | | 登録日 | 2020-06-07 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Pol theta reverse transcribes RNA and promotes RNA-templated DNA repair.
Sci Adv, 7, 2021
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8E23
 | | Human DNA polymerase theta in complex with allosteric inhibitor | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ... | | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | | 登録日 | 2022-08-13 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
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8E24
 | | Human DNA polymerase theta in complex with allosteric inhibitor | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ... | | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | | 登録日 | 2022-08-13 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
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3JW6
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7ZX0
 | | Crystal structure of Pol theta polymerase domain in complex with compound 5 | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[5-bromanyl-3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]oxy-~{N}-ethyl-~{N}-(3-methylphenyl)ethanamide, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... | | 著者 | Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. | | 登録日 | 2022-05-19 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J.Med.Chem., 65, 2022
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7ZUS
 | | Crystal structure of ternary complex of Pol theta polymerase domain | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), DNA (5'-D(P*TP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), ... | | 著者 | Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. | | 登録日 | 2022-05-13 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J.Med.Chem., 65, 2022
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7ZX1
 | | Crystal structure of Pol theta polymerase domain in complex with compound 22 | | 分子名称: | (2~{S},3~{R})-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-~{N}-methyl-~{N}-(3-methylphenyl)-3-oxidanyl-pyrrolidine-2-carboxamide, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... | | 著者 | Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. | | 登録日 | 2022-05-19 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.829 Å) | | 主引用文献 | Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J.Med.Chem., 65, 2022
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