PDB: 31489 件ウェブページステータス検索Chemie searchBIRD

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8UB6	Crystal Structure of a reconstructed Kaede-type Red Fluorescent Protein, LEA H62X, containing 3-methylhistidine at position 62 分子名称: LEAST EVOLVED ANCESTOR (LEA) GFP-LIKE PROTEINS 著者 Henderson, J.N, Mills, J.H. 登録日 2023-09-22 公開日 2023-11-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Capturing excited-state structural snapshots of evolutionary green-to-red photochromic fluorescent proteins. Front Chem, 11, 2023
8V4R	Crystal structure of Acetyl-CoA synthetase 2 in complex with AMP and CoA from Candida albicans 分子名称: ACETIC ACID, ADENOSINE MONOPHOSPHATE, Acetyl-coenzyme A synthetase 2, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-11-29 公開日 2023-12-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A single Leishmania adenylate forming enzyme of the ANL superfamily generates both acetyl- and acetoacetyl-CoA. J.Biol.Chem., 2024
7MXC	PRMT5:MEP50 complexed with adenosine 分子名称: ADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
6BX6	AMP-Activated protein kinase (AMPK) inhibition by SBI-0206965: alpha 2 kinase domain bound to SBI-0206965 分子名称: 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid, 5'-AMP-activated protein kinase catalytic subunit alpha-2 著者 Dite, T.A, Langendorf, C.G, Scott, J.W, Oakhill, J.S. 登録日 2017-12-17 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965. J. Biol. Chem., 293, 2018
8USL	Crystal Structure of Kemp Eliminase HG185 with bound transition state analogue, 280 K 分子名称: 6-NITROBENZOTRIAZOLE, Kemp eliminase 著者 Seifinoferest, B. 登録日 2023-10-27 公開日 2023-12-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling. J.Am.Chem.Soc., 146, 2024
6JZC	Structural basis of tubulin detyrosination 分子名称: GLYCEROL, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 2 著者 Chen, Z, Ling, Y, Zeyuan, G, Zhu, L. 登録日 2019-05-01 公開日 2019-07-17 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.201 Å) 主引用文献 Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nat Commun, 10, 2019
6KJH	Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 分子名称: Putative beta-lactamase, SULFATE ION 著者 Xiao, F, Sheng, D, Feng, Y, Li, W. 登録日 2019-07-22 公開日 2020-07-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
6KJQ	Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 分子名称: (3~{Z},5~{E},8~{S},9~{E},11~{E},14~{S},16~{R},17~{Z},19~{E},24~{R})-24-methyl-8,14,16-tris(oxidanyl)-1-oxacyclotetracosa-3,5,9,11,17,19-hexaen-2-one, Putative beta-lactamase 著者 Xiao, F, Dong, S, Feng, Y, Li, W. 登録日 2019-07-23 公開日 2020-07-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
6C4W	Structure of the yeast Pichia membranifaciens cytochrome c 分子名称: HEME C, cytochrome c 著者 McPherson, A. 登録日 2018-01-13 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Characterization of two crystal forms of cytochrome c from Valida membranifaciens to be published
8V1K	Crystal structure of outer membrane lipoprotein carrier protein (LolA) from Francisella tularensis 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Outer-membrane lipoprotein carrier protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-11-20 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of outer membrane lipoprotein carrier protein (LolA) from Francisella tularensis To be published
7MX3	Crystal structure of human RIPK3 complexed with GSK'843 分子名称: 1,2-ETHANEDIOL, 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine, Receptor-interacting serine/threonine-protein kinase 3 著者 Davies, K.A, Czabotar, P.E. 登録日 2021-05-18 公開日 2021-11-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nat Commun, 12, 2021
7N34	Structure of Yersinia aleksiciae Cap15 cyclic dinucleotide receptor, crystal form 1 分子名称: Cap15 著者 Duncan-Lowey, B, McNamara-Bordewick, N.K, Kranzusch, P.J. 登録日 2021-05-31 公開日 2021-11-17 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Effector-mediated membrane disruption controls cell death in CBASS antiphage defense. Mol.Cell, 81, 2021
7MXF	CD1c with antigen analogue 2 分子名称: (2S)-2,3-dihydroxypropyl hexadecanoate, 2,6-anhydro-1-deoxy-1-[(S)-hydroxy{[(4R,8S,12R,16R,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-D-glycero-D-galacto-heptitol, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cao, T.P, Shahine, A, Rossjohn, J. 登録日 2021-05-19 公開日 2021-11-17 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. J.Biol.Chem., 297, 2021
8UZO	Crystal Structure of Betaine aldehyde dehydrogenase (BetB) from Klebsiella aerogenes (ADP bound) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Betaine aldehyde dehydrogenase, SODIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-11-15 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Betaine aldehyde dehydrogenase (BetB) from Klebsiella aerogenes (ADP bound) To be published
7N0W	Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of alpha-conotoxin AusIA 分子名称: Acetylcholine-binding protein, Ribbon alpha-conotoxin AusIA 著者 Ho, T.N.T, Abraham, N, Lewis, R.J. 登録日 2021-05-26 公開日 2021-11-17 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of alpha-conotoxin AusIA. Sci Rep, 11, 2021
8UZ4	Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (Apo, P41212 form) 分子名称: MACROPHAGE MIGRATION INHIBITORY FACTOR 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-11-14 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (Apo, P41212 form) To be published
6K08	Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment 分子名称: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 著者 Zhang, F, Dai, Y. 登録日 2019-05-05 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.312 Å) 主引用文献 Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
7MXA	PRMT5:MEP50 complexed with inhibitor PF-06855800 分子名称: 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.713 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
8V2T	Phosphoheptose isomerase GMHA from Burkholderia pseudomallei bound to inhibitor Mut148591 分子名称: 1,5,6-trideoxy-6,6-difluoro-1-(N-hydroxyformamido)-6-phosphono-D-ribo-hexitol, CHLORIDE ION, Phosphoheptose isomerase, ... 著者 Junop, M.S, Brown, C, Szabla, R. 登録日 2023-11-23 公開日 2023-12-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.402 Å) 主引用文献 Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria. J.Med.Chem., 67, 2024
8USJ	Crystal Structure of Kemp Eliminase HG198 with bound transition state analogue, 280 K 分子名称: 6-NITROBENZOTRIAZOLE, Kemp eliminase 著者 Seifinoferest, B. 登録日 2023-10-27 公開日 2023-12-06 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling. J.Am.Chem.Soc., 146, 2024
8UZ8	Crystal Structure of CiaD from Campylobacter jejuni (C-terminal fragment, Orthorhombic P form) 分子名称: 1,4-BUTANEDIOL, 2-oxoglutarate:acceptor oxidoreductase, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-11-14 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of CiaD from Campylobacter jejuni (C-terminal fragment, Orthorhombic P form) To be published
8V4P	Crystal structure of Acetyl-CoA synthetase 2 in complex with Adenosine-5'-allylphosphate from Candida albicans 分子名称: 5'-O-{(S)-hydroxy[(prop-2-en-1-yl)oxy]phosphoryl}adenosine, Acetyl-coenzyme A synthetase 2, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-11-29 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 in complex with Adenosine-5'-allylphosphate from Candida albicans To be published
6C94	Structure Of Cytochrome P450 4B1 (CYP4B1) Complexed with the Inhibitor HET0016 分子名称: Cytochrome P450 4B1, N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamide, PROTOPORPHYRIN IX CONTAINING FE 著者 Hsu, M.-H, Johnson, E.F. 登録日 2018-01-25 公開日 2018-06-20 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1. J. Biol. Chem., 293, 2018
8V15	Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol 分子名称: (1P)-3',5-di(prop-2-en-1-yl)[1,1'-biphenyl]-2,4'-diol, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLN-PRO-LYS-FDL, ... 著者 Chakrabarti, R, Ghosh, A, Guan, X, Upadhyay, A, Dumpati, R.K, Munshi, S, Roy, S, Chall, S, Rahnamoun, A, Reverdy, C, Errasti, G, Delacroix, T. 登録日 2023-11-19 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion biorxiv, 2023
6K20	Structure of Apo YdiU 分子名称: MAGNESIUM ION, Protein adenylyltransferase SelO 著者 Li, B, Yang, Y, Ma, Y. 登録日 2019-05-13 公開日 2020-05-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structure of Apo-YdiU To Be Published

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