7MX3

Crystal structure of human RIPK3 complexed with GSK'843

Summary for 7MX3

Entry DOI	10.2210/pdb7mx3/pdb
Descriptor	Receptor-interacting serine/threonine-protein kinase 3, 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	kinase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	141932.01
Authors	Davies, K.A.,Czabotar, P.E. (deposition date: 2021-05-18, release date: 2021-11-24, Last modification date: 2024-04-03)
Primary citation	Meng, Y.,Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Horne, C.R.,Luo, C.,Garnier, J.M.,Liang, L.Y.,Cowan, A.D.,Samson, A.L.,Lessene, G.,Sandow, J.J.,Czabotar, P.E.,Murphy, J.M. Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nat Commun, 12:6783-6783, 2021 Cited by PubMed: 34811356 DOI: 10.1038/s41467-021-27032-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.23 Å)

Structure validation