7MX3
Crystal structure of human RIPK3 complexed with GSK'843
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Receptor-interacting serine/threonine-protein kinase 3 | polymer | 319 | 35090.0 | 4 | UniProt (Q9Y572) Pfam (PF00069) | Homo sapiens (Human) | RIP-like protein kinase 3,Receptor-interacting protein 3,RIP-3 |
| 2 | E, G, H, I (A, B, C, D) | 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine | non-polymer | 377.5 | 4 | Chemie (ZOV) | |||
| 3 | F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 315 (UniProt: Q9Y572)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ser 3 | Cys 3 | engineered mutation |
| Ala 110 | Cys 110 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 140360.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1572.0 | |
| All* | Total formula weight | 141932.0 |
