6BX6

AMP-Activated protein kinase (AMPK) inhibition by SBI-0206965: alpha 2 kinase domain bound to SBI-0206965

Summary for 6BX6

Entry DOI	10.2210/pdb6bx6/pdb
Descriptor	5'-AMP-activated protein kinase catalytic subunit alpha-2, 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid (2 entities in total)
Functional Keywords	transferase, serine/threonine-protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32071.08
Authors	Dite, T.A.,Langendorf, C.G.,Scott, J.W.,Oakhill, J.S. (deposition date: 2017-12-17, release date: 2018-05-09, Last modification date: 2023-10-04)
Primary citation	Dite, T.A.,Langendorf, C.G.,Hoque, A.,Galic, S.,Rebello, R.J.,Ovens, A.J.,Lindqvist, L.M.,Ngoei, K.R.W.,Ling, N.X.Y.,Furic, L.,Kemp, B.E.,Scott, J.W.,Oakhill, J.S. AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965. J. Biol. Chem., 293:8874-8885, 2018 Cited by PubMed: 29695504 DOI: 10.1074/jbc.RA118.003547 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation