6BX6
AMP-Activated protein kinase (AMPK) inhibition by SBI-0206965: alpha 2 kinase domain bound to SBI-0206965
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | polymer | 276 | 31581.8 | 1 | UniProt (P54646) Pfam (PF00069) | Homo sapiens (Human) | AMPK subunit alpha-2,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase |
| 2 | B (A) | 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid | non-polymer | 489.3 | 1 | Chemie (EDJ) |
Sequence modifications
A: 6 - 279 (UniProt: P54646)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | expression tag |
| Pro 5 | - | expression tag |
| Asp 172 | Thr 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31581.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 489.3 | |
| All* | Total formula weight | 32071.1 |
