8V2T

Phosphoheptose isomerase GMHA from Burkholderia pseudomallei bound to inhibitor Mut148591

Summary for 8V2T

• Entry DOI: 10.2210/pdb8v2t/pdb
• Related: 8V4J
• Descriptor: Phosphoheptose isomerase, 1,5,6-trideoxy-6,6-difluoro-1-(N-hydroxyformamido)-6-phosphono-D-ribo-hexitol, ZINC ION, ... (6 entities in total)
• Functional Keywords: heptose biosynthesis, isomerase-inhibitor complex, isomerase/inhibitor
• Biological source: Burkholderia pseudomallei 1106a
• Total number of polymer chains: 1
• Total formula weight: 23826.51

Authors

Junop, M.S.,Brown, C.,Szabla, R. (deposition date: 2023-11-23, release date: 2023-12-06, Last modification date: 2024-05-01)

• Primary citation: Moreau, F.,Atamanyuk, D.,Blaukopf, M.,Barath, M.,Herczeg, M.,Xavier, N.M.,Monbrun, J.,Airiau, E.,Henryon, V.,Leroy, F.,Floquet, S.,Bonnard, D.,Szabla, R.,Brown, C.,Junop, M.S.,Kosma, P.,Gerusz, V.; Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria.; J.Med.Chem., 67:6610-6623, 2024; PubMed: 38598312; DOI: 10.1021/acs.jmedchem.4c00037

Experimental method

X-RAY DIFFRACTION (1.402 Å)