PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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6DYR	C-terminal condensation domain of Ebony in complex with Carcinine 分子名称: Ebony, N-[2-(1H-imidazol-5-yl)ethyl]-beta-alaninamide 著者 Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. 登録日 2018-07-02 公開日 2019-01-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
7RG9	cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2021-07-14 公開日 2022-04-13 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
6W0Q	APE1 endonuclease product complex D148E 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2020-03-02 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Molecular and structural characterization of disease-associated APE1 polymorphisms. DNA Repair (Amst.), 91-92, 2020
7RGP	cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2021-07-15 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
6E0O	Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with pppA[3'-5']pA 分子名称: MAGNESIUM ION, RNA (5'-D(*(ATP))-R(P*A)-3'), cGAS/DncV-like nucleotidyltransferase in E. coli homolog 著者 Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. 登録日 2018-07-06 公開日 2019-02-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567, 2019
4PFN	Crystal structure of Plasmodium vivax SHMT with L-serine Schiff base 分子名称: CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, SERINE, ... 著者 Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U. 登録日 2014-04-30 公開日 2014-12-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control. Acta Crystallogr.,Sect.D, 70, 2014
6E1P	Structure of AtTPC1(DDE) in state 2 分子名称: CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1 著者 Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. 登録日 2018-07-10 公開日 2018-09-19 最終更新日 2024-12-25 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8T12	Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered. 分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION 著者 Biswal, M, Lu, J, Song, J. 登録日 2023-06-01 公開日 2024-01-17 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition. Commun Biol, 7, 2024
8SVC	Crystal Structure of SBP from Klebsiella pneumoniae 分子名称: Metal ABC transporter substrate-binding protein, SULFATE ION, ZINC ION 著者 Giles, M.W, Cole, G.B, Ng, D, McDevitt, C.A, Moraes, T.F. 登録日 2023-05-16 公開日 2024-01-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Zinc acquisition and its contribution to Klebsiella pneumoniae virulence. Front Cell Infect Microbiol, 13, 2023
4PGR	Crystal structure of YetJ from Bacillus Subtilis at pH 8 分子名称: Uncharacterized protein YetJ 著者 Liu, Q, Chang, Y, Hendrickson, W.A, New York Consortium on Membrane Protein Structure (NYCOMPS) 登録日 2014-05-02 公開日 2014-06-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for a pH-sensitive calcium leak across membranes. Science, 344, 2014
4PGX	Structure of human DNA polymerase beta complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2014-05-03 公開日 2014-09-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.077 Å) 主引用文献 The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta. Nucleic Acids Res., 42, 2015
6DZW	Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and 15B8 Fab and 8B6 ScFv 分子名称: 15B8 antibody heavy chain, 15B8 antibody light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Coleman, J.A, Yang, D, Gouaux, E. 登録日 2018-07-05 公開日 2019-04-24 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569, 2019
8T13	Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered 分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION 著者 Biswal, M, Lu, J, Song, J. 登録日 2023-06-01 公開日 2024-01-17 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition. Commun Biol, 7, 2024
4PH7	Structure of Osh6p in complex with phosphatidylinositol 4-phosphate 分子名称: (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, Oxysterol-binding protein homolog 6 著者 Delfosse, V, Moser von Filseck, J, Antonny, B, Bourguet, W, Drin, G. 登録日 2014-05-05 公開日 2015-07-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Science, 349, 2015
6E0M	Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase 分子名称: DIPHOSPHATE, cGAS/DncV-like nucleotidyltransferase in E. coli homolog 著者 Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. 登録日 2018-07-06 公開日 2019-02-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567, 2019
4PHE	Structure of human DNA polymerase beta complexed with T in the template base paired with incoming non-hydrolyzable GTP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2014-05-06 公開日 2015-05-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The spontaneous base substitution mechanisms of human DNA polymerase beta To Be Published
6UIO	Crystal structure of mouse CRES (Cystatin-Related Epididymal Spermatogenic) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Cystatin-8, ... 著者 Dominguez, M.J, Cornwall, G.A, Hewetson, A, Sutton, R.B. 登録日 2019-10-01 公開日 2020-07-01 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Maturation of the functional mouse CRES amyloid from globular form. Proc.Natl.Acad.Sci.USA, 117, 2020
7R5O	1.58 A STRUCTURE OF HUMAN APOFERRITIN OBTAINED FROM TITAN KRIOS 2 AT eBIC, DLS UNDER COMMISSIONING SESSION CM26464-2 分子名称: Ferritin heavy chain, N-terminally processed, SODIUM ION 著者 Clare, D.K. 登録日 2022-02-11 公開日 2022-06-22 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (1.6 Å) 主引用文献 Application of super-resolution and correlative double sampling in cryo-electron microscopy. Faraday Disc.Chem.Soc, 240, 2022
6UJ1	BACE2 mutant in complex with a macrocyclic compound 分子名称: (3S)-3-hydroxy-N-(2-methylpropyl)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-L-norleucinamide, Beta-secretase 2 著者 Yen, Y.C, Ghosh, A.K, Mesecar, A.D. 登録日 2019-10-02 公開日 2020-10-07 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. Acs Chem Neurosci, 12, 2021
4PRR	Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A 分子名称: 3-[3-(5-nitrofuran-2-yl)phenyl]propanoic acid, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Rechlin, C, Heine, A, Klebe, G. 登録日 2014-03-06 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase To be Published
7TDG	Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in inactivated conformation (Dataset-A) 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... 著者 Nayak, A.R, Samso, M. 登録日 2021-12-31 公開日 2022-03-09 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
7TDK	Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 3 (Dataset-A) 分子名称: CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... 著者 Nayak, A.R, Samso, M. 登録日 2021-12-31 公開日 2022-03-09 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
7TDH	Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in open conformation 分子名称: CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... 著者 Nayak, A.R, Samso, M. 登録日 2021-12-31 公開日 2022-03-09 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
6UHI	Closed-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human 分子名称: GLYCEROL, Ryanodine receptor 1 chimera 著者 Wu, R, Jedrzejczak, R, KIm, Y, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2019-09-27 公開日 2020-09-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Closed-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human to be published
7TDJ	Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 1(Dataset-A) 分子名称: CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... 著者 Nayak, A.R, Samso, M. 登録日 2021-12-31 公開日 2022-03-09 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022

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