6N34
| Crystal structure of the BTB domain of Human NS1-BP | 分子名称: | Influenza virus NS1A-binding protein | 著者 | Zhang, K, Shang, G, Padavannil, A, Fontoura, B, Chook, Y.M. | 登録日 | 2018-11-14 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5YTF
| Structure of large fragment of DNA Polymerase I from Thermus aquaticus Host-Guest complex with the unnatural base M-fC pair with dA | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*CP*GP*GP*CP*GP*CP*CP*GP*(92F)P*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... | 著者 | Zeng, H, Mondal, M, Song, R.Y, Zhang, J, Xia, B, Gao, Y.Q, Yi, C.Q. | 登録日 | 2017-11-17 | 公開日 | 2018-11-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl., 58, 2019
|
|
6SCZ
| Mycobacterium tuberculosis alanine racemase inhibited by DCS | 分子名称: | (~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylidene-[(4~{R})-3-oxidanylidene-1,2-oxazolidin-4-yl]azanium, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | de Chiara, C, Purkiss, A, Prosser, G, Homsak, M, de Carvalho, L.P.S. | 登録日 | 2019-07-26 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition. Nat.Chem.Biol., 16, 2020
|
|
6YHS
| Acinetobacter baumannii ribosome-amikacin complex - 50S subunit | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | 登録日 | 2020-03-30 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics. Structure, 28, 2020
|
|
6YGY
| tRNA-Guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-Amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | 分子名称: | 6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Nguyen, A, Heine, A, Klebe, G. | 登録日 | 2020-03-28 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts To Be Published
|
|
5YOX
| HD domain-containing protein YGK1(YGL101W) | 分子名称: | HD domain-containing protein YGL101W, ZINC ION | 著者 | Yang, J, Wang, F, Gao, Z, Zhou, K, Liu, Q. | 登録日 | 2017-10-31 | 公開日 | 2018-11-21 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | HD domain-containing protein YGK1(YGL101W) To Be Published
|
|
6YJC
| Crystal structure of p38alpha in complex with SR154 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-piperazin-1-yl-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Joerger, A.C, Schroeder, M, Roehm, S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-04-02 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.74100935 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
|
|
6YKR
| |
6SYC
| Crystal structure of the lysozyme in presence of bromophenol blue at pH 6.5 | 分子名称: | CHLORIDE ION, IMIDAZOLE, Lysozyme, ... | 著者 | Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. | 登録日 | 2019-09-27 | 公開日 | 2020-09-09 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Lysozyme crystals dyed with bromophenol blue: where has the dye gone? Acta Crystallogr D Struct Biol, 76, 2020
|
|
6YKP
| |
6YLT
| Translation initiation factor 4E in complex with 3-MeBn7GpppG mRNA 5' cap analog | 分子名称: | Eukaryotic translation initiation factor 4E, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-methylphenyl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate | 著者 | Kubacka, D, Wojcik, R, Baranowski, M.R, Kowalska, J, Jemielity, J. | 登録日 | 2020-04-07 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation. Pharmaceutics, 13, 2021
|
|
6YL0
| Crystal structure of YTHDC1 with compound T_96 | 分子名称: | DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1, ... | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | 登録日 | 2020-04-06 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystal structure of YTHDC1 with compound T_96 To Be Published
|
|
5YJ1
| Mouse Cereblon thalidomide binding domain complexed with R-form thalidomide | 分子名称: | 2-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]isoindole-1,3-dione, Protein cereblon, SULFATE ION, ... | 著者 | Mori, T, Hakoshima, T. | 登録日 | 2017-10-06 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of thalidomide enantiomer binding to cereblon Sci Rep, 8, 2018
|
|
6WG3
| Cryo-EM structure of human Cohesin-NIPBL-DNA complex | 分子名称: | Cohesin subunit SA-1, DNA (51-MER), Double-strand-break repair protein rad21 homolog, ... | 著者 | Shi, Z.B, Gao, H, Bai, X.C, Yu, H. | 登録日 | 2020-04-04 | 公開日 | 2020-05-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | 主引用文献 | Cryo-EM structure of the human cohesin-NIPBL-DNA complex. Science, 368, 2020
|
|
6MXD
| |
6SD5
| Structure of the RBM2 inner ring of Salmonella flagella MS-ring protein FliF with 22-fold symmetry applied | 分子名称: | Flagellar M-ring protein | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | 登録日 | 2019-07-26 | 公開日 | 2020-03-18 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nat Microbiol, 5, 2020
|
|
6WOP
| Crystal structure of gamma-aminobutyrate aminotransferase PuuE from Acinetobacter baumannii | 分子名称: | 4-aminobutyrate transaminase, CHLORIDE ION, D(-)-TARTARIC ACID | 著者 | Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-04-25 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of gamma-aminobutyrate aminotransferase PuuE from Acinetobacter baumannii To Be Published
|
|
6WUE
| Tetragonal crystal form of SbtB from Synechocystis PCC6803 | 分子名称: | ISOPROPYL ALCOHOL, Membrane-associated protein slr1513, SODIUM ION | 著者 | Bu, G, Simmons, C.R, Nielsen, D.R, Nannenga, B.L. | 登録日 | 2020-05-04 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Tetragonal crystal form of the cyanobacterial bicarbonate-transporter regulator SbtB from Synechocystis sp. PCC 6803. Acta Crystallogr.,Sect.F, 76, 2020
|
|
6WH4
| Crystal structure of HTR2A with inverse agonist | 分子名称: | 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ... | 著者 | Kim, K.L, Che, T, Krumm, B.E, Roth, B.L. | 登録日 | 2020-04-07 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor Cell(Cambridge,Mass.), 182, 2020
|
|
6WXF
| Cryo-EM reconstruction of VP5*/VP8* assembly from rhesus rotavirus particles - Intermediate conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Intermediate capsid protein VP6, ... | 著者 | Herrmann, T, Harrison, S.C, Jenni, S. | 登録日 | 2020-05-10 | 公開日 | 2021-01-20 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Functional refolding of the penetration protein on a non-enveloped virus. Nature, 590, 2021
|
|
6X3Y
| Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors | 分子名称: | Peptidyl-prolyl cis-trans isomerase A, tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1,21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate | 著者 | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | 登録日 | 2020-05-21 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
|
|
6SNK
| Crystal structure of the Collagen VI alpha3 N2 domain | 分子名称: | Collagen alpha-3(VI) chain | 著者 | Gebauer, J.M, Degefa, H.S, Paulsson, M, Wagener, R, Baumann, U. | 登録日 | 2019-08-26 | 公開日 | 2020-07-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a collagen VI alpha 3 chain VWA domain array: adaptability and functional implications of myopathy causing mutations. J.Biol.Chem., 295, 2020
|
|
6X4N
| Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-3-oxa-9,12,15,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 24) | 分子名称: | (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-3-oxa-9,12,15,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A | 著者 | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | 登録日 | 2020-05-22 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
|
|
6X4T
| Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Rujas, E, Sicard, T, Julien, J.P. | 登録日 | 2020-05-23 | 公開日 | 2020-10-14 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
|
|
6SFA
| |