4PH7

Structure of Osh6p in complex with phosphatidylinositol 4-phosphate

Summary for 4PH7

Entry DOI	10.2210/pdb4ph7/pdb
Related	3SPW
Descriptor	Oxysterol-binding protein homolog 6, (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (3 entities in total)
Functional Keywords	transport protein, osh proteins phosphatidylinositol phosphate lipid transport, lipid transport
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Endoplasmic reticulum membrane : Q02201
Total number of polymer chains	4
Total formula weight	211104.51
Authors	Delfosse, V.,Moser von Filseck, J.,Antonny, B.,Bourguet, W.,Drin, G. (deposition date: 2014-05-05, release date: 2015-07-29, Last modification date: 2023-12-20)
Primary citation	Moser von Filseck, J.,Copic, A.,Delfosse, V.,Vanni, S.,Jackson, C.L.,Bourguet, W.,Drin, G. INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Science, 349:432-436, 2015 Cited by PubMed: 26206936 DOI: 10.1126/science.aab1346 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation