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4PH7

Structure of Osh6p in complex with phosphatidylinositol 4-phosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0001786molecular_functionphosphatidylserine binding
A0005548molecular_functionphospholipid transporter activity
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0006887biological_processexocytosis
A0006897biological_processendocytosis
A0008289molecular_functionlipid binding
A0010314molecular_functionphosphatidylinositol-5-phosphate binding
A0015914biological_processphospholipid transport
A0015918biological_processsterol transport
A0016020cellular_componentmembrane
A0016125biological_processsterol metabolic process
A0030011biological_processmaintenance of cell polarity
A0032541cellular_componentcortical endoplasmic reticulum
A0032934molecular_functionsterol binding
A0034727biological_processpiecemeal microautophagy of the nucleus
A0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
A0055092biological_processsterol homeostasis
A0070273molecular_functionphosphatidylinositol-4-phosphate binding
A0070300molecular_functionphosphatidic acid binding
A0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
A0120015molecular_functionsterol transfer activity
B0001786molecular_functionphosphatidylserine binding
B0005548molecular_functionphospholipid transporter activity
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0006887biological_processexocytosis
B0006897biological_processendocytosis
B0008289molecular_functionlipid binding
B0010314molecular_functionphosphatidylinositol-5-phosphate binding
B0015914biological_processphospholipid transport
B0015918biological_processsterol transport
B0016020cellular_componentmembrane
B0016125biological_processsterol metabolic process
B0030011biological_processmaintenance of cell polarity
B0032541cellular_componentcortical endoplasmic reticulum
B0032934molecular_functionsterol binding
B0034727biological_processpiecemeal microautophagy of the nucleus
B0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
B0055092biological_processsterol homeostasis
B0070273molecular_functionphosphatidylinositol-4-phosphate binding
B0070300molecular_functionphosphatidic acid binding
B0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
B0120015molecular_functionsterol transfer activity
C0001786molecular_functionphosphatidylserine binding
C0005548molecular_functionphospholipid transporter activity
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006869biological_processlipid transport
C0006887biological_processexocytosis
C0006897biological_processendocytosis
C0008289molecular_functionlipid binding
C0010314molecular_functionphosphatidylinositol-5-phosphate binding
C0015914biological_processphospholipid transport
C0015918biological_processsterol transport
C0016020cellular_componentmembrane
C0016125biological_processsterol metabolic process
C0030011biological_processmaintenance of cell polarity
C0032541cellular_componentcortical endoplasmic reticulum
C0032934molecular_functionsterol binding
C0034727biological_processpiecemeal microautophagy of the nucleus
C0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
C0055092biological_processsterol homeostasis
C0070273molecular_functionphosphatidylinositol-4-phosphate binding
C0070300molecular_functionphosphatidic acid binding
C0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
C0120015molecular_functionsterol transfer activity
D0001786molecular_functionphosphatidylserine binding
D0005548molecular_functionphospholipid transporter activity
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006869biological_processlipid transport
D0006887biological_processexocytosis
D0006897biological_processendocytosis
D0008289molecular_functionlipid binding
D0010314molecular_functionphosphatidylinositol-5-phosphate binding
D0015914biological_processphospholipid transport
D0015918biological_processsterol transport
D0016020cellular_componentmembrane
D0016125biological_processsterol metabolic process
D0030011biological_processmaintenance of cell polarity
D0032541cellular_componentcortical endoplasmic reticulum
D0032934molecular_functionsterol binding
D0034727biological_processpiecemeal microautophagy of the nucleus
D0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
D0055092biological_processsterol homeostasis
D0070273molecular_functionphosphatidylinositol-4-phosphate binding
D0070300molecular_functionphosphatidic acid binding
D0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
D0120015molecular_functionsterol transfer activity
Functional Information from PDB Data
site_idAC1
Number of Residues31
Detailsbinding site for residue 2Y5 A 501
ChainResidue
ALEU64
AASN129
AHIS157
AHIS158
ATYR164
ASER183
ASER190
AALA191
AALA192
AGLN219
AVAL222
ATHR65
AILE227
ALYS351
AGLU355
AARG359
AHOH645
AHOH608
AHOH677
AHOH612
AHOH639
AHOH633
AARG66
AHOH644
AHOH656
AILE67
ATHR68
ALEU69
AGLN86
ALYS125
ALYS126

site_idAC2
Number of Residues27
Detailsbinding site for residue 2Y5 B 501
ChainResidue
BLEU64
BTHR65
BARG66
BILE67
BTHR68
BLEU69
BMET79
BARG82
BGLN86
BLYS126
BASN129
BHIS157
BHIS158
BTYR164
BSER183
BSER190
BALA191
BALA192
BTHR198
BVAL222
BILE234
BLYS351
BGLU355
BARG359
BHOH642
BHOH639
BHOH627

site_idAC3
Number of Residues23
Detailsbinding site for residue 2Y5 C 501
ChainResidue
CILE55
CLEU64
CTHR65
CARG66
CILE67
CTHR68
CLEU69
CLYS125
CLYS126
CASN129
CHIS157
CHIS158
CTYR164
CSER183
CALA192
CTHR198
CVAL222
CLYS351
CGLU355
CARG359
CHOH622
CHOH645
CHOH658

site_idAC4
Number of Residues28
Detailsbinding site for residue 2Y5 D 501
ChainResidue
DMET232
DILE234
DLYS351
DGLU355
DARG359
DHOH614
DHOH607
DHOH687
DHOH619
DHOH655
DLEU64
DTHR65
DARG66
DILE67
DTHR68
DLEU69
DARG82
DGLN86
DLYS126
DASN129
DHIS157
DHIS158
DTYR164
DSER183
DALA192
DTHR198
DVAL222
DILE227

Functional Information from PROSITE/UniProt
site_idPS01013
Number of Residues12
DetailsOSBP Oxysterol-binding protein family signature. EQtSHHPPecAY
ChainResidueDetails
AGLU153-TYR164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:23934110, ECO:0007744|PDB:4B2Z
ChainResidueDetails
ALEU64
DLEU64
DASN129
DSER183
AASN129
ASER183
BLEU64
BASN129
BSER183
CLEU64
CASN129
CSER183

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:26206936, ECO:0007744|PDB:4PH7
ChainResidueDetails
ALYS126
BARG359
CLYS126
CHIS157
CLYS351
CGLU355
CARG359
DLYS126
DHIS157
DLYS351
DGLU355
AHIS157
DARG359
ALYS351
AGLU355
AARG359
BLYS126
BHIS157
BLYS351
BGLU355

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358
ChainResidueDetails
ASER16
BSER16
CSER16
DSER16

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PDB entries from 2024-10-30

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