Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4PH7

Structure of Osh6p in complex with phosphatidylinositol 4-phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0005548	molecular_function	phospholipid transporter activity
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0006887	biological_process	exocytosis
A	0006897	biological_process	endocytosis
A	0008289	molecular_function	lipid binding
A	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
A	0015914	biological_process	phospholipid transport
A	0015918	biological_process	sterol transport
A	0016020	cellular_component	membrane
A	0016125	biological_process	sterol metabolic process
A	0030011	biological_process	maintenance of cell polarity
A	0032541	cellular_component	cortical endoplasmic reticulum
A	0032934	molecular_function	sterol binding
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
A	0055092	biological_process	sterol homeostasis
A	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
A	0070300	molecular_function	phosphatidic acid binding
A	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
A	0120015	molecular_function	sterol transfer activity
B	0001786	molecular_function	phosphatidylserine binding
B	0005548	molecular_function	phospholipid transporter activity
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0006887	biological_process	exocytosis
B	0006897	biological_process	endocytosis
B	0008289	molecular_function	lipid binding
B	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
B	0015914	biological_process	phospholipid transport
B	0015918	biological_process	sterol transport
B	0016020	cellular_component	membrane
B	0016125	biological_process	sterol metabolic process
B	0030011	biological_process	maintenance of cell polarity
B	0032541	cellular_component	cortical endoplasmic reticulum
B	0032934	molecular_function	sterol binding
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
B	0055092	biological_process	sterol homeostasis
B	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
B	0070300	molecular_function	phosphatidic acid binding
B	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
B	0120015	molecular_function	sterol transfer activity
C	0001786	molecular_function	phosphatidylserine binding
C	0005548	molecular_function	phospholipid transporter activity
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0006887	biological_process	exocytosis
C	0006897	biological_process	endocytosis
C	0008289	molecular_function	lipid binding
C	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
C	0015914	biological_process	phospholipid transport
C	0015918	biological_process	sterol transport
C	0016020	cellular_component	membrane
C	0016125	biological_process	sterol metabolic process
C	0030011	biological_process	maintenance of cell polarity
C	0032541	cellular_component	cortical endoplasmic reticulum
C	0032934	molecular_function	sterol binding
C	0034727	biological_process	piecemeal microautophagy of the nucleus
C	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
C	0055092	biological_process	sterol homeostasis
C	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
C	0070300	molecular_function	phosphatidic acid binding
C	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
C	0120015	molecular_function	sterol transfer activity
D	0001786	molecular_function	phosphatidylserine binding
D	0005548	molecular_function	phospholipid transporter activity
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006869	biological_process	lipid transport
D	0006887	biological_process	exocytosis
D	0006897	biological_process	endocytosis
D	0008289	molecular_function	lipid binding
D	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
D	0015914	biological_process	phospholipid transport
D	0015918	biological_process	sterol transport
D	0016020	cellular_component	membrane
D	0016125	biological_process	sterol metabolic process
D	0030011	biological_process	maintenance of cell polarity
D	0032541	cellular_component	cortical endoplasmic reticulum
D	0032934	molecular_function	sterol binding
D	0034727	biological_process	piecemeal microautophagy of the nucleus
D	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
D	0055092	biological_process	sterol homeostasis
D	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
D	0070300	molecular_function	phosphatidic acid binding
D	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
D	0120015	molecular_function	sterol transfer activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue 2Y5 A 501

Chain	Residue
A	LEU64
A	ASN129
A	HIS157
A	HIS158
A	TYR164
A	SER183
A	SER190
A	ALA191
A	ALA192
A	GLN219
A	VAL222
A	THR65
A	ILE227
A	LYS351
A	GLU355
A	ARG359
A	HOH645
A	HOH608
A	HOH677
A	HOH612
A	HOH639
A	HOH633
A	ARG66
A	HOH644
A	HOH656
A	ILE67
A	THR68
A	LEU69
A	GLN86
A	LYS125
A	LYS126

site_id	AC2
Number of Residues	27
Details	binding site for residue 2Y5 B 501

Chain	Residue
B	LEU64
B	THR65
B	ARG66
B	ILE67
B	THR68
B	LEU69
B	MET79
B	ARG82
B	GLN86
B	LYS126
B	ASN129
B	HIS157
B	HIS158
B	TYR164
B	SER183
B	SER190
B	ALA191
B	ALA192
B	THR198
B	VAL222
B	ILE234
B	LYS351
B	GLU355
B	ARG359
B	HOH642
B	HOH639
B	HOH627

site_id	AC3
Number of Residues	23
Details	binding site for residue 2Y5 C 501

Chain	Residue
C	ILE55
C	LEU64
C	THR65
C	ARG66
C	ILE67
C	THR68
C	LEU69
C	LYS125
C	LYS126
C	ASN129
C	HIS157
C	HIS158
C	TYR164
C	SER183
C	ALA192
C	THR198
C	VAL222
C	LYS351
C	GLU355
C	ARG359
C	HOH622
C	HOH645
C	HOH658

site_id	AC4
Number of Residues	28
Details	binding site for residue 2Y5 D 501

Chain	Residue
D	MET232
D	ILE234
D	LYS351
D	GLU355
D	ARG359
D	HOH614
D	HOH607
D	HOH687
D	HOH619
D	HOH655
D	LEU64
D	THR65
D	ARG66
D	ILE67
D	THR68
D	LEU69
D	ARG82
D	GLN86
D	LYS126
D	ASN129
D	HIS157
D	HIS158
D	TYR164
D	SER183
D	ALA192
D	THR198
D	VAL222
D	ILE227

Functional Information from PROSITE/UniProt

site_id	PS01013
Number of Residues	12
Details	OSBP Oxysterol-binding protein family signature. EQtSHHPPecAY

Chain	Residue	Details
A	GLU153-TYR164

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1011
Details	Region: {"description":"OSBP-related domain (ORD)","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23934110","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4B2Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26206936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)