4PRR
Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A
Summary for 4PRR
Entry DOI | 10.2210/pdb4prr/pdb |
Related | 2IKG 2IKH 3DN5 4NKC 4PR4 4PRT |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[3-(5-nitrofuran-2-yl)phenyl]propanoic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36771.78 |
Authors | Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-03-06, release date: 2015-04-08, Last modification date: 2023-09-20) |
Primary citation | Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G. Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase To be Published, |
Experimental method | X-RAY DIFFRACTION (1.01 Å) |
Structure validation
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