4PRR

Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A

Summary for 4PRR

• Entry DOI: 10.2210/pdb4prr/pdb
• Related: 2IKG 2IKH 3DN5 4NKC 4PR4 4PRT
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[3-(5-nitrofuran-2-yl)phenyl]propanoic acid, ... (4 entities in total)
• Functional Keywords: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 36771.78

Authors

Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-03-06, release date: 2015-04-08, Last modification date: 2023-09-20)

• Primary citation: Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G.; Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase; To be Published,

Experimental method

X-RAY DIFFRACTION (1.01 Å)