3RDH
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![BU of 3rdh by Molmil](/molmil-images/mine/3rdh) | X-ray induced covalent inhibition of 14-3-3 | 分子名称: | 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION | 著者 | Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. | 登録日 | 2011-04-01 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
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3SAY
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![BU of 3say by Molmil](/molmil-images/mine/3say) | Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142 | 分子名称: | (3Z)-N,N-diethyl-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, (4S)-2-METHYL-2,4-PENTANEDIOL, FORMIC ACID, ... | 著者 | Mazanetz, M.P, Cheng, R.K.Y, Rowan, F, Laughton, C.A, Barker, J.J, Fischer, P.M. | 登録日 | 2011-06-03 | 公開日 | 2012-06-13 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.231 Å) | 主引用文献 | Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142 To be Published
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5L4K
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![BU of 5l4k by Molmil](/molmil-images/mine/5l4k) | The human 26S proteasome lid | 分子名称: | 26S proteasome complex subunit DSS1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | 著者 | Schweitzer, A, Aufderheide, A, Rudack, T, Beck, F. | 登録日 | 2016-05-25 | 公開日 | 2016-09-07 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of the human 26S proteasome at a resolution of 3.9 angstrom. Proc.Natl.Acad.Sci.USA, 113, 2016
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7QO6
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![BU of 7qo6 by Molmil](/molmil-images/mine/7qo6) | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... | 著者 | Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D. | 登録日 | 2021-12-23 | 公開日 | 2022-03-16 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
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7QO5
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![BU of 7qo5 by Molmil](/molmil-images/mine/7qo5) | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... | 著者 | Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D. | 登録日 | 2021-12-23 | 公開日 | 2022-03-16 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
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2C1N
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![BU of 2c1n by Molmil](/molmil-images/mine/2c1n) | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE | 著者 | Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. | 登録日 | 2005-09-16 | 公開日 | 2005-11-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
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7QO3
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![BU of 7qo3 by Molmil](/molmil-images/mine/7qo3) | Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid) | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit RPN10, ... | 著者 | Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D. | 登録日 | 2021-12-23 | 公開日 | 2022-04-13 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
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2C1J
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![BU of 2c1j by Molmil](/molmil-images/mine/2c1j) | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE | 著者 | Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. | 登録日 | 2005-09-15 | 公開日 | 2005-11-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
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7QGT
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![BU of 7qgt by Molmil](/molmil-images/mine/7qgt) | Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA. | 分子名称: | 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Hutchin, A, Kopec, J, Majtan, T, Zuhra, K, Szabo, C. | 登録日 | 2021-12-10 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.691 Å) | 主引用文献 | H 2 S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine. Cell.Mol.Life Sci., 79, 2022
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4BBQ
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![BU of 4bbq by Molmil](/molmil-images/mine/4bbq) | Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11) | 分子名称: | 1,2-ETHANEDIOL, LYSINE-SPECIFIC DEMETHYLASE 2A, ZINC ION | 著者 | Allerston, C.K, Watson, A.A, Edlich, C, Li, B, Chen, Y, Ball, L, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Laue, E.D, Gileadi, O. | 登録日 | 2012-09-27 | 公開日 | 2012-10-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal Structure of the Cxxc and Phd Domain of Human Lysine-Specific Demethylase 2A (Kdm2A)(Fbxl11) To be Published
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7RRO
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![BU of 7rro by Molmil](/molmil-images/mine/7rro) | Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia | 分子名称: | Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... | 著者 | Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. | 登録日 | 2021-08-10 | 公開日 | 2021-10-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell, 184, 2021
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4A64
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![BU of 4a64 by Molmil](/molmil-images/mine/4a64) | Crystal structure of the N-terminal domain of human Cul4B at 2.57A resolution | 分子名称: | 1,2-ETHANEDIOL, CULLIN-4B | 著者 | Vollmar, M, Ayinampudi, V, Cooper, C, Guo, K, Krojer, T, Muniz, J.R.C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Bullock, A. | 登録日 | 2011-10-31 | 公開日 | 2012-02-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Crystal Structure of the N-Terminal Domain of Human Cul4B at 2.57A Resolution To be Published
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6HT7
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![BU of 6ht7 by Molmil](/molmil-images/mine/6ht7) | Crystal structure of the WT human mitochondrial chaperonin (ADP:BeF3)14 complex | 分子名称: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | 著者 | Jebara, F, Patra, M, Azem, A, Hirsch, J. | 登録日 | 2018-10-03 | 公開日 | 2020-04-29 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal structure of the WT human mitochondrial football Hsp60-Hsp10(ADPBeFx)14 complex Nat Commun, 2020
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1DDB
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![BU of 1ddb by Molmil](/molmil-images/mine/1ddb) | STRUCTURE OF MOUSE BID, NMR, 20 STRUCTURES | 分子名称: | PROTEIN (BID) | 著者 | Mcdonnell, J.M, Fushman, D, Milliman, C, Korsmeyer, S.J, Cowburn, D. | 登録日 | 1999-02-19 | 公開日 | 1999-08-30 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists. Cell(Cambridge,Mass.), 96, 1999
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6KL7
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![BU of 6kl7 by Molmil](/molmil-images/mine/6kl7) | Beta-arrestin 1 mutant S13D/T275D | 分子名称: | 1,2-ETHANEDIOL, BARIUM ION, Beta-arrestin-1 | 著者 | Kang, H, Choi, H.J. | 登録日 | 2019-07-29 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | 主引用文献 | Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins. Structure, 28, 2020
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2BID
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![BU of 2bid by Molmil](/molmil-images/mine/2bid) | HUMAN PRO-APOPTOTIC PROTEIN BID | 分子名称: | PROTEIN (BID) | 著者 | Chou, J.J, Li, H, Salvesen, G.S, Yuan, J, Wagner, G. | 登録日 | 1999-01-27 | 公開日 | 2000-02-02 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell(Cambridge,Mass.), 96, 1999
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8G1P
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![BU of 8g1p by Molmil](/molmil-images/mine/8g1p) | Co-crystal structure of Compound 11 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Ghimire Rijal, S, Wurz, R.P, Vaish, A. | 登録日 | 2023-02-02 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun, 14, 2023
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3I4B
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![BU of 3i4b by Molmil](/molmil-images/mine/3i4b) | Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor | 分子名称: | Glycogen synthase kinase-3 beta, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide | 著者 | Ter Haar, E. | 登録日 | 2009-07-01 | 公開日 | 2010-01-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
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7TNY
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![BU of 7tny by Molmil](/molmil-images/mine/7tny) | Cryo-EM structure of RIG-I in complex with p2dsRNA | 分子名称: | Antiviral innate immune response receptor RIG-I, ZINC ION, p2dsRNA | 著者 | Wang, W, Pyle, A.M. | 登録日 | 2022-01-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TNX
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![BU of 7tnx by Molmil](/molmil-images/mine/7tnx) | Cryo-EM structure of RIG-I in complex with p3dsRNA | 分子名称: | Antiviral innate immune response receptor RIG-I, ZINC ION, p3dsRNAa, ... | 著者 | Wang, W, Pyle, A.M. | 登録日 | 2022-01-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TO2
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![BU of 7to2 by Molmil](/molmil-images/mine/7to2) | |
7TO1
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![BU of 7to1 by Molmil](/molmil-images/mine/7to1) | |
7TO0
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![BU of 7to0 by Molmil](/molmil-images/mine/7to0) | Cryo-EM structure of RIG-I in complex with OHdsRNA | 分子名称: | Antiviral innate immune response receptor RIG-I, OHdsRNA, ZINC ION | 著者 | Wang, W, Pyle, A.M. | 登録日 | 2022-01-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TNZ
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![BU of 7tnz by Molmil](/molmil-images/mine/7tnz) | Cryo-EM structure of RIG-I in complex with p1dsRNA | 分子名称: | Antiviral innate immune response receptor RIG-I, ZINC ION, p1dsRNA | 著者 | Wang, W, Pyle, A.M. | 登録日 | 2022-01-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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3J2I
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![BU of 3j2i by Molmil](/molmil-images/mine/3j2i) | Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide exit tunnel | 分子名称: | Eukaryotic translation initiation factor 6, Proliferation-associated protein 2G4 | 著者 | Bradatsch, B, Leidig, C, Granneman, S, Gnaedig, M, Tollervey, D, Boettcher, B, Beckmann, R, Hurt, E. | 登録日 | 2012-10-04 | 公開日 | 2012-11-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (11.9 Å) | 主引用文献 | Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat.Struct.Mol.Biol., 19, 2012
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