6KQN
| Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 6 nt | 分子名称: | DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Zhang, Y, Li, L, Ebright, R.H. | 登録日 | 2019-08-18 | 公開日 | 2020-03-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.489 Å) | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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6REY
| Human 20S-PA200 Proteasome Complex | 分子名称: | INOSITOL HEXAKISPHOSPHATE, Proteasome activator complex subunit 4, Proteasome subunit alpha type-1, ... | 著者 | Toste Rego, A, da Fonseca, P.C.A. | 登録日 | 2019-04-12 | 公開日 | 2019-09-04 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes. Mol.Cell, 76, 2019
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6X4P
| Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 28) | 分子名称: | (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A | 著者 | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | 登録日 | 2020-05-22 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
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6WVV
| Plasmodium vivax M17 leucyl aminopeptidase | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, M17 leucyl aminopeptidase, ... | 著者 | Malcolm, T.R, Drinkwater, N, McGowan, S. | 登録日 | 2020-05-07 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases. J.Biol.Chem., 296, 2020
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6X05
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6X0R
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6X1T
| Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kalagiri, R, Stanfield, R.L, Wilson, I.A, Hunter, T. | 登録日 | 2020-05-19 | 公開日 | 2021-02-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 118, 2021
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5XWV
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3A26
| Crystal structure of P. horikoshii TYW2 in complex with MeSAdo | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, TETRAETHYLENE GLYCOL, Uncharacterized protein PH0793 | 著者 | Umitsu, M, Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2009-04-28 | 公開日 | 2009-09-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 Proc.Natl.Acad.Sci.USA, 106, 2009
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6X3C
| Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F1037 (47) | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Chaires, H.A, Fraser, J.S. | 登録日 | 2020-05-21 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6X42
| High Resolution Crystal Structure Analysis of SERA5E from plasmodium falciparum | 分子名称: | 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CALCIUM ION, ... | 著者 | Clarke, O.B, Smith, N.A, Lee, M, Smith, B.J. | 登録日 | 2020-05-21 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen. Protein Sci., 29, 2020
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6WML
| Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod) | 分子名称: | (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Appleby, T.C, Perry, J.K, Mish, M, Villasenor, A.G, Mackman, R.L. | 登録日 | 2020-04-21 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J.Med.Chem., 63, 2020
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5YFP
| Cryo-EM Structure of the Exocyst Complex | 分子名称: | Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ... | 著者 | Mei, K, Li, Y, Wang, S, Shao, G, Wang, J, Ding, Y, Luo, G, Yue, P, Liu, J.J, Wang, X, Dong, M.Q, Guo, W, Wang, H.W. | 登録日 | 2017-09-21 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of the exocyst complex Nat. Struct. Mol. Biol., 25, 2018
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6WLC
| Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-5'-Monophosphate | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | 著者 | Kim, Y, Maltseva, N, Jedrzejczak, R, Endres, M, Chang, C, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-04-19 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol, 4, 2021
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6RIE
| Structure of Vaccinia Virus DNA-dependent RNA polymerase co-transcriptional capping complex | 分子名称: | DNA-dependent RNA polymerase subunit rpo132, DNA-dependent RNA polymerase subunit rpo147, DNA-dependent RNA polymerase subunit rpo18, ... | 著者 | Hillen, H.S, Bartuli, J, Grimm, C, Dienemann, C, Bedenk, K, Szalar, A, Fischer, U, Cramer, P. | 登録日 | 2019-04-23 | 公開日 | 2019-12-18 | 最終更新日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes. Cell, 179, 2019
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5Y3M
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6RIZ
| Crystal structure of gp41-1 intein (C1A, F65W, D107C) | 分子名称: | gp41-1 intein | 著者 | Beyer, H.M, Lountos, G.T, Mikula, M.K, Wlodawer, A, Iwai, H. | 登録日 | 2019-04-25 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms. Int J Mol Sci, 21, 2020
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6RLV
| Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine | 分子名称: | 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, GLYCEROL, MALONATE ION, ... | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | 登録日 | 2019-05-02 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
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6KON
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6WXD
| SARS-CoV-2 Nsp9 RNA-replicase | 分子名称: | Non-structural protein 9, SULFATE ION | 著者 | Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J. | 登録日 | 2020-05-10 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9. Iscience, 23, 2020
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6WXO
| De novo TIM barrel-ferredoxin fold fusion homodimer with 2-histidine 2-glutamate centre TFD-HE | 分子名称: | GLYCEROL, SULFATE ION, TFD-HE | 著者 | Caldwell, S.J, Zeymer, C, Haydon, I.C, Huang, P, Hilvert, D, Baker, D. | 登録日 | 2020-05-11 | 公開日 | 2020-11-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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6RNX
| Crystal structure of the essential repressor DdrO from radiation-resistant Deinococcus bacteria (Deinococcus deserti) | 分子名称: | CHLORIDE ION, HTH-type transcriptional regulator DdrOC | 著者 | Arnoux, P, Siponen, M.I, Pignol, D, De Groot, A, Blanchard, L. | 登録日 | 2019-05-09 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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6WTS
| CryoEM structure of the C. sordellii lethal toxin TcsL in complex with SEMA6A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SEMA6A, ... | 著者 | Kucharska, I, Rubinstein, J.L, Julien, J.P. | 登録日 | 2020-05-03 | 公開日 | 2020-07-08 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Cell, 182, 2020
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6X04
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6WYA
| RTX (Reverse Transcription Xenopolymerase) in complex with a DNA duplex and dAMPNPP | 分子名称: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W. | 登録日 | 2020-05-12 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | How a B family DNA polymerase has been evolved to copy RNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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