6X3C

Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F1037 (47)

Summary for 6X3C

• Entry DOI: 10.2210/pdb6x3c/pdb
• Descriptor: Virginiamycin A acetyltransferase, THIOACETIC ACID S-{2-[3-(2-HYDROXY-3,3-DIMETHYL-4-PHOSPHONOOXY-BUTYRYLAMINO)-PROPIONYLAMINO]-ETHYL} ESTER, (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, ... (8 entities in total)
• Functional Keywords: acetyltransferase, transferase
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 6
• Total formula weight: 149156.34

Authors

Chaires, H.A.,Fraser, J.S. (deposition date: 2020-05-21, release date: 2020-11-18, Last modification date: 2023-10-18)

• Primary citation: Li, Q.,Pellegrino, J.,Lee, D.J.,Tran, A.A.,Chaires, H.A.,Wang, R.,Park, J.E.,Ji, K.,Chow, D.,Zhang, N.,Brilot, A.F.,Biel, J.T.,van Zundert, G.,Borrelli, K.,Shinabarger, D.,Wolfe, C.,Murray, B.,Jacobson, M.P.,Muhle, E.,Chesneau, O.,Fraser, J.S.,Seiple, I.B.; Synthetic group A streptogramin antibiotics that overcome Vat resistance.; Nature, 586:145-150, 2020; PubMed: 32968273; DOI: 10.1038/s41586-020-2761-3

Experimental method

X-RAY DIFFRACTION (3.05 Å)