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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X3C

Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F1037 (47)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0046677	biological_process	response to antibiotic
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0046677	biological_process	response to antibiotic
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SXA A 301

Chain	Residue
A	GLY75
F	TYR57
F	ALA85
F	ASN86
F	HIS87
F	LYS116
F	O7S302
F	HOH405
A	PRO76
A	TRP126
A	ILE127
A	GLY128
A	ARG129
A	ALA146
A	ALA147
A	HOH403

site_id	AC2
Number of Residues	15
Details	binding site for residue O7S A 302

Chain	Residue
A	TYR59
A	GLY84
A	ALA85
A	ASN86
A	HIS87
A	HIS97
A	LEU98
A	MET107
A	PRO108
A	LEU110
B	PHE200
B	MET208
E	ASN20
E	TYR42
E	SXA301

site_id	AC3
Number of Residues	3
Details	binding site for residue PO4 A 303

Chain	Residue
A	LYS153
A	LYS167
A	PHE168

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	LYS27
A	GLY38
A	GLU39
A	ARG70

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 305

Chain	Residue
A	TYR57
A	HOH407

site_id	AC6
Number of Residues	17
Details	binding site for residue SXA B 301

Chain	Residue
B	SER73
B	GLY75
B	PRO76
B	TRP126
B	ILE127
B	GLY128
B	ARG129
B	ALA146
B	ALA147
B	HOH401
C	TYR57
C	ALA85
C	ASN86
C	HIS87
C	MET89
C	MET134
C	O7S302

site_id	AC7
Number of Residues	17
Details	binding site for residue O7S B 302

Chain	Residue
A	MET208
B	TYR59
B	GLY84
B	ALA85
B	ASN86
B	HIS87
B	HIS97
B	LEU98
B	MET107
B	PRO108
B	LEU110
B	LEU113
B	SXA303
B	PO4305
D	LEU23
D	TYR42
D	ASP44

site_id	AC8
Number of Residues	18
Details	binding site for residue SXA B 303

Chain	Residue
B	TYR57
B	ALA85
B	ASN86
B	HIS87
B	LYS116
B	MET134
B	O7S302
B	HOH405
B	HOH410
B	HOH411
D	GLY75
D	PRO76
D	TRP126
D	ILE127
D	GLY128
D	ARG129
D	ALA146
D	ALA147

site_id	AC9
Number of Residues	3
Details	binding site for residue MG B 304

Chain	Residue
B	ASN164
C	ASN164
D	ASN164

site_id	AD1
Number of Residues	5
Details	binding site for residue PO4 B 305

Chain	Residue
D	HOH501
B	TYR57
B	TYR59
B	O7S302
B	HOH403

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 308

Chain	Residue
B	LYS153
B	LYS167
B	PHE168

site_id	AD3
Number of Residues	16
Details	binding site for residue SXA C 301

Chain	Residue
C	GLY75
C	PRO76
C	TRP126
C	ILE127
C	GLY128
C	ARG129
C	ALA146
C	ALA147
C	ARG170
C	HOH406
D	TYR57
D	ALA85
D	ASN86
D	HIS87
D	MET134
D	O7S401

site_id	AD4
Number of Residues	15
Details	binding site for residue O7S C 302

Chain	Residue
B	ASN20
B	TYR42
B	ASP44
B	SXA301
C	TYR59
C	GLY84
C	ASN86
C	HIS87
C	HIS97
C	LEU98
C	MET107
C	PRO108
C	LEU110
E	PHE200
E	MET208

site_id	AD5
Number of Residues	3
Details	binding site for residue PO4 C 303

Chain	Residue
C	LYS27
C	GLU39
C	ARG70

site_id	AD6
Number of Residues	7
Details	binding site for residue PO4 C 305

Chain	Residue
A	ARG88
A	ASP112
C	ARG88
C	MET107
C	SER109
C	ASP112
C	HOH403

site_id	AD7
Number of Residues	2
Details	binding site for residue CL C 306

Chain	Residue
B	HOH414
C	TYR57

site_id	AD8
Number of Residues	14
Details	binding site for residue O7S D 401

Chain	Residue
C	LEU23
C	TYR42
C	ASP44
C	SXA301
D	TYR59
D	GLY84
D	ALA85
D	ASN86
D	HIS87
D	HIS97
D	LEU98
D	MET107
D	PRO108
D	LEU110

site_id	AD9
Number of Residues	4
Details	binding site for residue PO4 D 402

Chain	Residue
C	ASN203
D	ARG88
D	ASP112
D	HOH503

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 D 404

Chain	Residue
D	LYS27
D	GLY38
D	GLU39
D	ARG70

site_id	AE2
Number of Residues	2
Details	binding site for residue CL D 405

Chain	Residue
D	TYR57
D	HOH506

site_id	AE3
Number of Residues	18
Details	binding site for residue SXA E 301

Chain	Residue
A	TYR57
A	ALA85
A	ASN86
A	HIS87
A	MET89
A	LYS116
A	MET134
A	O7S302
E	SER73
E	GLY75
E	PRO76
E	TRP126
E	ILE127
E	GLY128
E	ARG129
E	ALA146
E	ALA147
E	HOH401

site_id	AE4
Number of Residues	15
Details	binding site for residue O7S E 302

Chain	Residue
E	TYR59
E	GLY84
E	ALA85
E	ASN86
E	HIS87
E	HIS97
E	LEU98
E	MET107
E	PRO108
E	LEU110
E	LEU113
F	LEU23
F	TYR42
F	ASP44
F	SXA301

site_id	AE5
Number of Residues	4
Details	binding site for residue MG E 303

Chain	Residue
A	ASN164
E	ASN164
E	PRO165
F	ASN164

site_id	AE6
Number of Residues	2
Details	binding site for residue PO4 E 305

Chain	Residue
E	ARG88
F	ASN203

site_id	AE7
Number of Residues	3
Details	binding site for residue PO4 E 306

Chain	Residue
E	LYS153
E	LYS167
E	PHE168

site_id	AE8
Number of Residues	2
Details	binding site for residue CL E 308

Chain	Residue
E	TYR57
E	HOH403

site_id	AE9
Number of Residues	15
Details	binding site for residue SXA F 301

Chain	Residue
E	TYR57
E	ALA85
E	ASN86
E	HIS87
E	MET89
E	LYS116
E	O7S302
F	PRO76
F	TRP126
F	ILE127
F	GLY128
F	ARG129
F	ALA146
F	ALA147
F	ARG170

site_id	AF1
Number of Residues	14
Details	binding site for residue O7S F 302

Chain	Residue
A	LEU23
A	TYR42
A	ASP44
A	SXA301
D	MET208
F	TYR59
F	GLY84
F	ASN86
F	HIS87
F	HIS97
F	LEU98
F	MET107
F	PRO108
F	LEU110

site_id	AF2
Number of Residues	4
Details	binding site for residue PO4 F 303

Chain	Residue
F	LYS27
F	GLY38
F	GLU39
F	ARG70

site_id	AF3
Number of Residues	1
Details	binding site for residue CL F 305

Chain	Residue
A	HOH405

site_id	AF4
Number of Residues	2
Details	binding site for residue CL F 306

Chain	Residue
F	LYS46
F	ARG129

site_id	AF5
Number of Residues	10
Details	binding site for Di-peptide PO4 B 306 and LYS B 105

Chain	Residue
A	HIS7
B	GLY102
B	TRP103
B	GLU104
B	TYR106
B	MET107
D	HIS7
F	GLY102
F	LYS105
F	TYR106

site_id	AF6
Number of Residues	18
Details	binding site for Di-peptide PO4 B 306 and LYS F 105

Chain	Residue
A	HIS7
B	GLY102
B	GLY102
B	TRP103
B	GLU104
B	TYR106
B	TYR106
B	MET107
D	HIS7
D	HIS7
F	LYS46
F	GLY102
F	TRP103
F	GLU104
F	TYR106
F	TYR106
F	MET107
F	ARG129

site_id	AF7
Number of Residues	10
Details	binding site for Di-peptide SO4 B 307 and LYS B 27

Chain	Residue
B	GLU12
B	PHE25
B	ILE26
B	PRO28
B	THR29
B	ILE30
B	VAL37
B	GLY38
B	GLU39
B	ARG70

site_id	AF8
Number of Residues	6
Details	binding site for Di-peptide PO4 C 304 and PHE C 168

Chain	Residue
C	LYS153
C	LYS167
C	ILE169
C	ARG170
C	HOH401
C	HOH402

site_id	AF9
Number of Residues	9
Details	binding site for Di-peptide PO4 C 304 and LYS C 153

Chain	Residue
C	VAL137
C	VAL151
C	THR152
C	ASN154
C	LEU166
C	LYS167
C	PHE168
C	HOH401
C	HOH402

site_id	AG1
Number of Residues	7
Details	binding site for Di-peptide PO4 D 403 and LYS D 153

Chain	Residue
D	VAL137
D	VAL151
D	THR152
D	ASN154
D	LEU166
D	LYS167
D	PHE168

site_id	AG2
Number of Residues	10
Details	binding site for Di-peptide PO4 E 304 and LYS E 27

Chain	Residue
E	GLU12
E	PHE25
E	ILE26
E	PRO28
E	THR29
E	ILE30
E	VAL37
E	GLY38
E	GLU39
E	ARG70

site_id	AG3
Number of Residues	5
Details	binding site for Di-peptide PO4 E 307 and LYS E 167

Chain	Residue
E	GLY162
E	PRO165
E	LEU166
E	PHE168
E	PO4306

site_id	AG4
Number of Residues	7
Details	binding site for Di-peptide PO4 F 304 and LYS F 153

Chain	Residue
F	VAL151
F	THR152
F	ASN154
F	VAL155
F	LEU166
F	LYS167
F	PHE168

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGrdVtImpgVkIGdgAiIAaeAvVtknV

Chain	Residue	Details
A	ILE127-VAL155

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS87
B	HIS87
C	HIS87
D	HIS87
E	HIS87
F	HIS87

237735

PDB entries from 2025-06-18

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