PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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1H2U	Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG 分子名称: 20 KDA NUCLEAR CAP BINDING PROTEIN, 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE, 80 KDA NUCLEAR CAP BINDING PROTEIN, ... 著者 Mazza, C, Segref, A, Mattaj, I.W, Cusack, S. 登録日 2002-08-16 公開日 2002-10-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Large-Scale Induced Fit Recognition of an M(7)Gpppg CAP Analogue by the Human Nuclear CAP-Binding Complex Embo J., 21, 2002
6NUJ	HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436 分子名称: (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, Integrase 著者 Lindenberger, J.J, Kvaratskhelia, M. 登録日 2019-02-01 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.100027 Å) 主引用文献 HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife, 8, 2019
8JAQ	Structure of CRL2APPBP2 bound with RxxGP degron (tetramer) 分子名称: Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... 著者 Zhao, S, Zhang, K, Xu, C. 登録日 2023-05-06 公開日 2023-10-18 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
6K1S	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors 分子名称: 1,2-ETHANEDIOL, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, DIMETHYL SULFOXIDE, ... 著者 Tong, S, Lin, H. 登録日 2019-05-12 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. Acs Med.Chem.Lett., 10, 2019
4DPI	BACE-1 in complex with HEA-macrocyclic inhibitor, MV078512 分子名称: (4S,8E,11R)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-16-methyl-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraene-2,13-dione, Beta-secretase 1 著者 Lindberg, J, Borkakoti, N, Derbyshire, D. 登録日 2012-02-13 公開日 2012-07-11 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Bioorg.Med.Chem., 20, 2012
6DQO	Crystal structure of SsuE FMN reductase Y118A mutant in FMN bound form. 分子名称: FLAVIN MONONUCLEOTIDE, FMN reductase (NADPH), GLYCEROL 著者 McFarlane, J.S, Ellis, H.R, Lamb, A.L. 登録日 2018-06-11 公開日 2019-01-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.705 Å) 主引用文献 Not as easy as pi : An insertional residue does not explain the pi-helix gain-of-function in two-component FMN reductases. Protein Sci., 28, 2019
8JAS	Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer) 分子名称: Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... 著者 Zhao, S, Zhang, K, Xu, C. 登録日 2023-05-07 公開日 2023-10-18 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
8JAV	Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) 分子名称: Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... 著者 Zhao, S, Zhang, K, Xu, C. 登録日 2023-05-07 公開日 2023-10-18 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
6NMN	Ternary complex structure of the T130K mutant of ANT-4'' with Neomycin and ATP (No Pyrophosphate) 分子名称: ADENOSINE MONOPHOSPHATE, Kanamycin nucleotidyltransferase, MAGNESIUM ION, ... 著者 Cuneo, M.J, Selvaraj, B. 登録日 2019-01-11 公開日 2020-01-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Catch and release: A novel variation of the archetypal nucleotidyl transfer reaction to be published
6NWK	Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with dexamethasone and PGC1a coregulator fragment 分子名称: ACETYL GROUP, DEXAMETHASONE, DIMETHYL SULFOXIDE, ... 著者 Liu, X, Ortlund, E.A. 登録日 2019-02-06 公開日 2019-10-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids. Mol.Pharmacol., 96, 2019
4DCM	Crystal Structure of methyltransferase RlmG modifying G1835 of 23S rRNA in Escherichia coli 分子名称: DI(HYDROXYETHYL)ETHER, Ribosomal RNA large subunit methyltransferase G, S-ADENOSYLMETHIONINE 著者 Zhang, H, Gao, Z.Q, Dong, Y.H. 登録日 2012-01-17 公開日 2012-08-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.297 Å) 主引用文献 Structural insights into the function of 23S rRNA methyltransferase RlmG (m2G1835) from Escherichia coli. Rna, 18, 2012
6DB6	Crystal structure of anti-HIV-1 V3 Fab 311-11D in complex with a HIV-1 gp120 V3 peptide from MN strain 分子名称: HIV-1 gp120 V3 peptide from MN strain, Human monoclonal anti-HIV-1 gp120 V3 antibody 311-11D Fab heavy chain, Human monoclonal anti-HIV-1 gp120 V3 antibody 311-11D Fab light chain, ... 著者 Chan, K.-W, Kong, X.-P. 登録日 2018-05-02 公開日 2018-07-11 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection. J. Virol., 92, 2018
4E28	Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor 分子名称: 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ... 著者 Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. 登録日 2012-03-07 公開日 2012-11-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.302 Å) 主引用文献 Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J.Med.Chem., 55, 2012
1H2T	Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG 分子名称: 20 KDA NUCLEAR CAP BINDING PROTEIN, 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE, 80 KDA NUCLEAR CAP BINDING PROTEIN, ... 著者 Mazza, C, Segref, A, Mattaj, I.W, Cusack, S. 登録日 2002-08-16 公開日 2002-10-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Large-Scale Induced Fit Recognition of an M(7)Gpppg CAP Analogue by the Human Nuclear CAP-Binding Complex Embo J., 21, 2002
4DHS	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 分子名称: (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... 著者 Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. 登録日 2012-01-30 公開日 2013-07-31 最終更新日 2013-09-04 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
6D66	Crystal structure of the human dual specificity 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein mbp3_16 分子名称: 1,2-ETHANEDIOL, D-ALANINE, DI(HYDROXYETHYL)ETHER, ... 著者 Gumpena, R, Waugh, D.S, Lountos, G.T. 登録日 2018-04-20 公開日 2018-09-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.226 Å) 主引用文献 MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
4DH4	Macrophage migration inhibitory factor Toxoplasma gondii 分子名称: MIF, SULFATE ION 著者 Richardson, J.M. 登録日 2012-01-27 公開日 2012-11-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor. J.Biol.Chem., 288, 2013
6DB5	Crystal structure of anti-HIV-1 V3 Fab TA6 in complex with a HIV-1 gp120 V3 peptide from NY5 strain 分子名称: HIV-1 gp120 V3 peptide from NY5 strain, Human monoclonal anti-HIV-1 gp120 V3 antibody TA6 Fab heavy chain, Human monoclonal anti-HIV-1 gp120 V3 antibody TA6 Fab light chain 著者 Chan, K.-W, Kong, X.-P. 登録日 2018-05-02 公開日 2018-07-11 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (2.599 Å) 主引用文献 Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection. J. Virol., 92, 2018
1H2V	Structure of the human nuclear cap-binding-complex (CBC) 分子名称: 20 KDA NUCLEAR CAP BINDING PROTEIN, 80 KDA NUCLEAR CAP BINDING PROTEIN 著者 Mazza, C, Segref, A, Mattaj, I.W, Cusack, S. 登録日 2002-08-16 公開日 2002-10-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Large-Scale Induced Fit Recognition of an M(7)Gpppg CAP Analogue by the Human Nuclear CAP-Binding Complex Embo J., 21, 2002
3OKI	Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide 分子名称: (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-25 公開日 2010-12-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes Bioorg.Med.Chem.Lett., 21, 2010
6DNH	Cryo-EM structure of human CPSF-160-WDR33-CPSF-30-PAS RNA complex at 3.4 A resolution 分子名称: Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*C)-3'), ... 著者 Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. 登録日 2018-06-06 公開日 2018-06-27 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3OMM	Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid 分子名称: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-27 公開日 2011-01-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties Bioorg.Med.Chem.Lett., 21, 2011
3OOU	The structure of a protein with unkown function from Listeria innocua 分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Lin2118 protein 著者 Fan, Y, Mack, J, Feldman, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2010-08-31 公開日 2010-09-22 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 The structure of a protein with unkown function from Listeria innocua To be Published
6DTN	The structure of NTMT1 in complex with compound DC100-1 分子名称: (6D6)PPKRIA(NH2), DC100-1, N-terminal Xaa-Pro-Lys N-methyltransferase 1 著者 Noinaj, N, Chen, D, Huang, R. 登録日 2018-06-18 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.475 Å) 主引用文献 Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1. J. Med. Chem., 62, 2019
3L5Z	Crystal structure of transcriptional regulator, GntR family from Bacillus cereus 分子名称: 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, Transcriptional regulator, ... 著者 Chang, C, Hatzos, C, Feldmann, B, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-12-22 公開日 2010-01-05 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of transcriptional regulator, GntR family from Bacillus cereus To be Published

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