5WX5
 
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6KOE
 | | X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis | | 分子名称: | 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE, AA3-600 quinol oxidase subunit I, AA3-600 quinol oxidase subunit IIII, ... | | 著者 | Xu, J, Ding, Z, Liu, B, Li, J, Gennis, R.B, Zhu, J. | | 登録日 | 2019-08-09 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5IJ8
 | | Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor | | 分子名称: | 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... | | 著者 | Gajiwala, K.S, Brooun, A, Deng, Y.-L, Liu, W. | | 登録日 | 2016-03-01 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7, 2016
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5IEK
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6KV3
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5IFE
 | | Crystal structure of the human SF3b core complex | | 分子名称: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | | 著者 | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | | 登録日 | 2016-02-25 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol.Cell, 64, 2016
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5IG0
 | | Crystal structure of S. rosetta CaMKII hub | | 分子名称: | CAMK/CAMK2 protein kinase, GLYCEROL, SULFATE ION | | 著者 | Bhattacharyya, M, Gee, C.L, Barros, T, Kuriyan, J. | | 登録日 | 2016-02-26 | | 公開日 | 2016-03-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
Elife, 5, 2016
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5IGX
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5IHN
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6KXE
 | | The ishigamide ketosynthase/chain length factor | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Ketosynthase, ... | | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | | 登録日 | 2019-09-10 | | 公開日 | 2020-05-06 | | 最終更新日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase.
Nat.Chem.Biol., 16, 2020
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5WDH
 | | Motor domain of human kinesin family member C1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC1, MAGNESIUM ION, ... | | 著者 | Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2017-07-05 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.248 Å) | | 主引用文献 | Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
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5WDP
 | | H-Ras mutant L120A bound to GMP-PNP at 277K | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | | 登録日 | 2017-07-05 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
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5II6
 | | Crystal structure of the ZP-N1 domain of mouse sperm receptor ZP2 at 0.95 A resolution | | 分子名称: | Zona pellucida sperm-binding protein 2 | | 著者 | Dioguardi, E, Han, L, Nishimura, K, De Sanctis, D, Jovine, L. | | 登録日 | 2016-03-01 | | 公開日 | 2017-06-14 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Structural Basis of Egg Coat-Sperm Recognition at Fertilization.
Cell, 169, 2017
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6KXX
 | | Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound A) | | 分子名称: | 1-(4-chlorophenyl)-6-methyl-3-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid, PGC1alpha, Peroxisome proliferator-activated receptor alpha | | 著者 | Yoshida, T, Tachibana, K, Oki, H, Doi, M, Fukuda, S, Yuzuriha, T, Tabata, R, Ishimoto, K, Kawahara, K, Ohkubo, T, Miyachi, H, Doi, T. | | 登録日 | 2019-09-14 | | 公開日 | 2020-05-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.
Sci Rep, 10, 2020
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6KRO
 | | Tankyrase-2 in complex with RK-582 | | 分子名称: | 6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-4-fluoranyl-1-methyl-1'-(8-methyl-4-oxidanylidene-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-2-yl)spiro[indole-3,4'-piperidine]-2-one, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2019-08-22 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer.
J.Med.Chem., 63, 2020
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5IJI
 | | Fragment of nitrate/nitrite sensor histidine kinase NarQ (WT) in symmetric holo state | | 分子名称: | EICOSANE, NITRATE ION, Nitrate/nitrite sensor histidine kinase NarQ | | 著者 | Gushchin, I, Melnikov, I, Polovinkin, V, Ishchenko, A, Popov, A, Gordeliy, V. | | 登録日 | 2016-03-02 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Mechanism of transmembrane signaling by sensor histidine kinases.
Science, 356, 2017
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5WI6
 | | Human beta-1 tryptase mutant Ile99Cys | | 分子名称: | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, SULFATE ION, Tryptase alpha/beta-1 | | 著者 | Eigenbrot, C, Maun, H.R. | | 登録日 | 2017-07-18 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer.
J. Biol. Chem., 293, 2018
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6KO7
 | | Crystal structure of the Ethidium bound RamR determined with XtaLAB Synergy | | 分子名称: | ETHIDIUM, Putative regulatory protein, SULFATE ION | | 著者 | Matsumoto, T, Nakashima, R, Yamano, A, Nishino, K. | | 登録日 | 2019-08-08 | | 公開日 | 2019-10-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Development of a structure determination method using a multidrug-resistance regulator protein as a framework.
Biochem.Biophys.Res.Commun., 518, 2019
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5WIJ
 | | JAK2 Pseudokinase in complex with NU6140 | | 分子名称: | 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Tyrosine-protein kinase JAK2 | | 著者 | Li, Q, Eck, M.J, Li, K, Park, E. | | 登録日 | 2017-07-19 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
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5IJL
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5WIL
 | | JAK2 Pseudokinase in complex with AZD7762 | | 分子名称: | 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, Tyrosine-protein kinase JAK2 | | 著者 | Li, Q, Eck, M.J, Li, K, Park, E. | | 登録日 | 2017-07-19 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
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5IK2
 | | Caldalaklibacillus thermarum F1-ATPase (epsilon mutant) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP synthase epsilon chain, ATP synthase gamma chain, ... | | 著者 | Ferguson, S.A, Cook, G.M, Montgomery, M.G, Leslie, A.G.W, Walker, J.E. | | 登録日 | 2016-03-03 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Regulation of the thermoalkaliphilic F1-ATPase from Caldalkalibacillus thermarum.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5WS9
 | | Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, ATP and allosteric activator AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Zhong, W, Cai, Q, El Sahili, A, Lescar, J, Dedon, P.C. | | 登録日 | 2016-12-06 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
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5WUD
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | MAGNESIUM ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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5WUN
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