6KRO

Tankyrase-2 in complex with RK-582

Summary for 6KRO

• Entry DOI: 10.2210/pdb6kro/pdb
• Descriptor: Tankyrase-2, 6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-4-fluoranyl-1-methyl-1'-(8-methyl-4-oxidanylidene-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-2-yl)spiro[indole-3,4'-piperidine]-2-one, ZINC ION, ... (7 entities in total)
• Functional Keywords: tankyrase, parp, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 25369.83

Authors

Niwa, H.,Shirai, F.,Sato, S.,Tsumura, T.,Okue, M.,Shirouzu, M.,Seimiya, H.,Umehara, T. (deposition date: 2019-08-22, release date: 2020-04-01, Last modification date: 2024-03-27)

• Primary citation: Shirai, F.,Mizutani, A.,Yashiroda, Y.,Tsumura, T.,Kano, Y.,Muramatsu, Y.,Chikada, T.,Yuki, H.,Niwa, H.,Sato, S.,Washizuka, K.,Koda, Y.,Mazaki, Y.,Jang, M.K.,Yoshida, H.,Nagamori, A.,Okue, M.,Watanabe, T.,Kitamura, K.,Shitara, E.,Honma, T.,Umehara, T.,Shirouzu, M.,Fukami, T.,Seimiya, H.,Yoshida, M.,Koyama, H.; Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer.; J.Med.Chem., 63:4183-4204, 2020; PubMed: 32202790; DOI: 10.1021/acs.jmedchem.0c00045

Experimental method

X-RAY DIFFRACTION (1.9 Å)