5WS9

Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, ATP and allosteric activator AMP

Summary for 5WS9

Entry DOI	10.2210/pdb5ws9/pdb
Related	5WRP 5WS8 5WSA 5WSB 5WSC
Descriptor	Pyruvate kinase, MAGNESIUM ION, OXALATE ION, ... (8 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	208470.04
Authors	Zhong, W.,Cai, Q.,El Sahili, A.,Lescar, J.,Dedon, P.C. (deposition date: 2016-12-06, release date: 2017-11-15, Last modification date: 2023-11-08)
Primary citation	Zhong, W.,Cui, L.,Goh, B.C.,Cai, Q.,Ho, P.,Chionh, Y.H.,Yuan, M.,Sahili, A.E.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Lescar, J.,Dedon, P.C. Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8:1986-1986, 2017 Cited by PubMed: 29215013 DOI: 10.1038/s41467-017-02086-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation