5WRP

T-state crystal structure of pyruvate kinase from Mycobacterium tuberculosis

Summary for 5WRP

Entry DOI	10.2210/pdb5wrp/pdb
Related	5WS8 5WS9 5WSA 5WSB 5WSC
Descriptor	Pyruvate kinase, PHOSPHATE ION (3 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	204437.23
Authors	Zhong, W.,Cai, Q.,El Sahili, A.,Lescar, J.,Dedon, P.C. (deposition date: 2016-12-02, release date: 2017-11-15, Last modification date: 2024-03-20)
Primary citation	Zhong, W.,Cui, L.,Goh, B.C.,Cai, Q.,Ho, P.,Chionh, Y.H.,Yuan, M.,Sahili, A.E.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Lescar, J.,Dedon, P.C. Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8:1986-1986, 2017 Cited by PubMed: 29215013 DOI: 10.1038/s41467-017-02086-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation