Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004743 | molecular_function | pyruvate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004743 | molecular_function | pyruvate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004743 | molecular_function | pyruvate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004743 | molecular_function | pyruvate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0030955 | molecular_function | potassium ion binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 501 |
| Chain | Residue |
| A | THR374 |
| A | GLN375 |
| A | SER376 |
| A | THR379 |
| A | HOH620 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 501 |
| Chain | Residue |
| B | THR379 |
| B | HOH601 |
| B | THR374 |
| B | GLN375 |
| B | SER376 |
| B | ASP378 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 C 501 |
| Chain | Residue |
| C | THR374 |
| C | GLN375 |
| C | SER376 |
| C | ASP378 |
| C | THR379 |
| C | SER458 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 501 |
| Chain | Residue |
| D | THR374 |
| D | GLN375 |
| D | SER376 |
| D | ASP378 |
| D | THR379 |
| D | SER458 |
| D | HOH639 |
Functional Information from PROSITE/UniProt
| site_id | PS00110 |
| Number of Residues | 13 |
| Details | PYRUVATE_KINASE Pyruvate kinase active site signature. VpVIAKLEKpEAI |
| Chain | Residue | Details |
| A | VAL213-ILE225 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG33 | |
| B | ASN35 | |
| B | SER37 | |
| B | ASP67 | |
| B | GLU220 | |
| B | GLY243 | |
| B | ASP244 | |
| B | THR276 | |
| C | ARG33 | |
| C | ASN35 | |
| C | SER37 | |
| A | ASN35 | |
| C | ASP67 | |
| C | GLU220 | |
| C | GLY243 | |
| C | ASP244 | |
| C | THR276 | |
| D | ARG33 | |
| D | ASN35 | |
| D | SER37 | |
| D | ASP67 | |
| D | GLU220 | |
| A | SER37 | |
| D | GLY243 | |
| D | ASP244 | |
| D | THR276 | |
| A | ASP67 | |
| A | GLU220 | |
| A | GLY243 | |
| A | ASP244 | |
| A | THR276 | |
| B | ARG33 | |
| Chain | Residue | Details |
| A | ARG74 | |
| A | LYS155 | |
| B | ARG74 | |
| B | LYS155 | |
| C | ARG74 | |
| C | LYS155 | |
| D | ARG74 | |
| D | LYS155 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS218 | |
| B | LYS218 | |
| C | LYS218 | |
| D | LYS218 | |
| Chain | Residue | Details |
| A | SER37 | |
| B | SER37 | |
| C | SER37 | |
| D | SER37 | |
