PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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4YXO	Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3). 分子名称: 4-ethylbenzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Rechlin, C, Heine, A, Klebe, G. 登録日 2015-03-23 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies. J.Med.Chem., 59, 2016
7RQY	Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... 著者 Kwon, D.H, Suo, Y, Lee, S.-Y. 登録日 2021-08-08 公開日 2022-06-01 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
4PPI	Crystal structure of Bcl-xL hexamer 分子名称: Bcl-2-like protein 1, GLYCEROL 著者 Sreekanth, R, Yoon, H.S. 登録日 2014-02-27 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.851 Å) 主引用文献 Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport Sci Rep, 5, 2015
7RQV	Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... 著者 Kwon, D.H, Suo, Y, Lee, S.-Y. 登録日 2021-08-08 公開日 2022-06-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
4ZEL	Human dopamine beta-hydroxylase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ... 著者 Vendelboe, T.V, Harris, P, Christensen, H.E.M, Harlos, K, Walter, T, Zhao, Y, Omari, K. 登録日 2015-04-20 公開日 2016-04-20 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The crystal structure of human dopamine beta-hydroxylase at 2.9 angstrom resolution. Sci Adv, 2, 2016
7RQX	Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... 著者 Kwon, D.H, Suo, Y, Lee, S.-Y. 登録日 2021-08-08 公開日 2022-06-01 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
4HRA	Crystal Structure of DOT1L in Complex with EPZ-5676 分子名称: 5'-[{cis-3-[2-(5-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl}(propan-2-yl)amino]-5'-deoxyadenosine, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... 著者 Jin, L. 登録日 2012-10-26 公開日 2013-07-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood, 122, 2013
7RQU	Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... 著者 Kwon, D.H, Suo, Y, Lee, S.-Y. 登録日 2021-08-08 公開日 2022-06-01 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
7RQW	Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... 著者 Kwon, D.H, Suo, Y, Lee, S.-Y. 登録日 2021-08-08 公開日 2022-06-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
6D0A	Crystal structure of Kynurenine Aminotransferase-II in apo-form, at 1.47 A resolution 分子名称: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 著者 Jayawickrama, G.S, Sun, G, Nematollahi, A, Church, W.B. 登録日 2018-04-10 公開日 2018-05-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.46809423 Å) 主引用文献 Crystal structure of Kynurenine Aminotransferase-II in apo-form To Be Published
4HIR	SOLUTION STRUCTURE OF RECOMBINANT HIRUDIN AND THE LYS-47 (RIGHT ARROW) GLU MUTANT. A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY 分子名称: HIRUDIN VARIANT-1 著者 Clore, G.M, Gronenborn, A.M. 登録日 1988-12-19 公開日 1990-01-15 最終更新日 2024-11-06 実験手法 SOLUTION NMR 主引用文献 Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Biochemistry, 28, 1989
7RNY	Carbonic Anhydrase II in complex with 3-ureido benzenesulfonamide derivative 分子名称: 3-{[benzyl(methyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Combs, J, McKenna, R. 登録日 2021-07-30 公開日 2022-06-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. J.Med.Chem., 65, 2022
7RNZ	Carbonic Anhydrase II in complex with 4-ureido benzenesulfonamide derivative 分子名称: 4-[(methylcarbamoyl)amino]benzene-1-sulfonamide, AZIDE ION, Carbonic anhydrase 2, ... 著者 Combs, J, McKenna, R. 登録日 2021-07-30 公開日 2022-06-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. J.Med.Chem., 65, 2022
8RNE	HLA-E*01:03 in complex with SARS-CoV-2 Nsp13 peptide, VMPLSAPTL 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, E alpha chain variant, ... 著者 Sun, R, Achour, A, Sala, B.M, Sandalova, T. 登録日 2024-01-09 公開日 2024-12-04 最終更新日 2025-01-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness. Plos Pathog., 20, 2024
4Z6E	Structure of human DNA polymerase beta 279NA mutant complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2015-04-04 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.752 Å) 主引用文献 Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase beta. Biochem. J., 475, 2018
6D31	Structure of human Usb1 with adenosine 5'-monophosphate 分子名称: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, GLYCEROL, ... 著者 Nomura, Y, Montemayor, E.J, Butcher, S.E. 登録日 2018-04-14 公開日 2018-09-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1. Nucleic Acids Res., 46, 2018
6D0N	Crystal structure of a CLC-type fluoride/proton antiporter, V319G mutant 分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ... 著者 Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C. 登録日 2018-04-10 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 A CLC-type F-/H+antiporter in ion-swapped conformations. Nat. Struct. Mol. Biol., 25, 2018
6D3R	Thermostablilized dephosphorylated chicken CFTR 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator 著者 Fay, J.F, Riordan, J.R. 登録日 2018-04-16 公開日 2018-10-17 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel. Biochemistry, 57, 2018
4Q78	Structure-assisted design of carborane-based inhibitors of carbonic anhydrase 分子名称: 1-(sulfamoylamino)methyl-1,2-dicarba-closo-dodecaborane, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Mader, P, Brynda, J, Rezacova, P. 登録日 2014-04-24 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Carborane-based carbonic anhydrase inhibitors: insight into CAII/CAIX specificity from a high-resolution crystal structure, modeling, and quantum chemical calculations. Biomed Res Int, 2014, 2014
6U4Y	Crystal Structure of an EZH2-EED Complex in an Oligomeric State 分子名称: Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Jiao, L, Liu, X. 登録日 2019-08-26 公開日 2020-07-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 A partially disordered region connects gene repression and activation functions of EZH2. Proc.Natl.Acad.Sci.USA, 117, 2020
7PG2	Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1 分子名称: Insulin, Isoform Short of Insulin receptor 著者 Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. 登録日 2021-08-12 公開日 2022-02-02 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
6D1L	Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects 分子名称: 4-[(but-2-yn-1-yl)selanyl]benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Peat, T.S, Angeli, A, di Cesare Mannelli, L, Micheli, L, Ghelardini, C, Supuran, C.T. 登録日 2018-04-12 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects. Eur J Med Chem, 154, 2018
8RNF	HLA-E*01:03 in complex with SARS-CoV-2 Omicron Nsp13 peptide, VIPLSAPTL 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, E alpha chain variant, ... 著者 Sun, R, Achour, A, Sala, B.M, Sandalova, T. 登録日 2024-01-09 公開日 2024-12-04 最終更新日 2025-01-22 実験手法 X-RAY DIFFRACTION (1.872 Å) 主引用文献 Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness. Plos Pathog., 20, 2024
4Q6F	Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3K4 histone peptide 分子名称: 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2A, ZINC ION, ... 著者 Tallant, C, Overvoorde, L, Krojer, T, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Ciulli, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2014-04-22 公開日 2014-05-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23, 2015
2A3A	Crystal structure of Aspergillus fumigatus chitinase B1 in complex with theophylline 分子名称: SULFATE ION, THEOPHYLLINE, chitinase 著者 Rao, F.V, Andersen, O.A, Vora, K.A, DeMartino, J.A, van Aalten, D.M.F. 登録日 2005-06-24 公開日 2005-09-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes. Chem.Biol., 12, 2005

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