Human dopamine beta-hydroxylase

Summary for 4ZEL

DescriptorDopamine beta-hydroxylase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordshydroxylase, dimer, copper binding, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationSoluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein P09172
Total number of polymer chains2
Total molecular weight132883.7
Vendelboe, T.V.,Harris, P.,Christensen, H.E.M.,Harlos, K.,Walter, T.,Zhao, Y.,Omari, K. (deposition date: 2015-04-20, release date: 2016-04-20, Last modification date: 2020-07-29)
Primary citation
Vendelboe, T.V.,Harris, P.,Zhao, Y.,Walter, T.S.,Harlos, K.,El Omari, K.,Christensen, H.E.
The crystal structure of human dopamine beta-hydroxylase at 2.9 angstrom resolution.
Sci Adv, 2:e1500980-e1500980, 2016
PubMed: 27152332 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.1500980
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27215 0.6% 1.9% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16