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4ZEL

Human dopamine beta-hydroxylase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001974biological_processblood vessel remodeling
A0001975biological_processresponse to amphetamine
A0002443biological_processleukocyte mediated immunity
A0003824molecular_functioncatalytic activity
A0004497molecular_functionmonooxygenase activity
A0004500molecular_functiondopamine beta-monooxygenase activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0006589biological_processoctopamine biosynthetic process
A0007268biological_processchemical synaptic transmission
A0007613biological_processmemory
A0007626biological_processlocomotory behavior
A0008306biological_processassociative learning
A0008542biological_processvisual learning
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016715molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031410cellular_componentcytoplasmic vesicle
A0031418molecular_functionL-ascorbic acid binding
A0034451cellular_componentcentriolar satellite
A0034466cellular_componentchromaffin granule lumen
A0034774cellular_componentsecretory granule lumen
A0042309biological_processhomoiothermy
A0042310biological_processvasoconstriction
A0042420biological_processdopamine catabolic process
A0042421biological_processnorepinephrine biosynthetic process
A0042423biological_processcatecholamine biosynthetic process
A0042584cellular_componentchromaffin granule membrane
A0042593biological_processglucose homeostasis
A0042596biological_processfear response
A0042711biological_processmaternal behavior
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0048149biological_processbehavioral response to ethanol
A0048265biological_processresponse to pain
A0050900biological_processleukocyte migration
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904705biological_processregulation of vascular associated smooth muscle cell proliferation
A1905562biological_processregulation of vascular endothelial cell proliferation
A2001236biological_processregulation of extrinsic apoptotic signaling pathway
B0001974biological_processblood vessel remodeling
B0001975biological_processresponse to amphetamine
B0002443biological_processleukocyte mediated immunity
B0003824molecular_functioncatalytic activity
B0004497molecular_functionmonooxygenase activity
B0004500molecular_functiondopamine beta-monooxygenase activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0006589biological_processoctopamine biosynthetic process
B0007268biological_processchemical synaptic transmission
B0007613biological_processmemory
B0007626biological_processlocomotory behavior
B0008306biological_processassociative learning
B0008542biological_processvisual learning
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016715molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031410cellular_componentcytoplasmic vesicle
B0031418molecular_functionL-ascorbic acid binding
B0034451cellular_componentcentriolar satellite
B0034466cellular_componentchromaffin granule lumen
B0034774cellular_componentsecretory granule lumen
B0042309biological_processhomoiothermy
B0042310biological_processvasoconstriction
B0042420biological_processdopamine catabolic process
B0042421biological_processnorepinephrine biosynthetic process
B0042423biological_processcatecholamine biosynthetic process
B0042584cellular_componentchromaffin granule membrane
B0042593biological_processglucose homeostasis
B0042596biological_processfear response
B0042711biological_processmaternal behavior
B0043231cellular_componentintracellular membrane-bounded organelle
B0045202cellular_componentsynapse
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0048149biological_processbehavioral response to ethanol
B0048265biological_processresponse to pain
B0050900biological_processleukocyte migration
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1904705biological_processregulation of vascular associated smooth muscle cell proliferation
B1905562biological_processregulation of vascular endothelial cell proliferation
B2001236biological_processregulation of extrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00084
Number of Residues8
DetailsCU2_MONOOXYGENASE_1 Copper type II, ascorbate-dependent monooxygenases signature 1. HHMevFqC
ChainResidueDetails
AHIS262-CYS269

site_idPS00085
Number of Residues13
DetailsCU2_MONOOXYGENASE_2 Copper type II, ascorbate-dependent monooxygenases signature 2. HiFasqlHTHltG
ChainResidueDetails
AHIS405-GLY417

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000255
ChainResidueDetails
ATYR230
AHIS412
BTYR230
BHIS412

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000305|PubMed:27152332
ChainResidueDetails
BHIS333
BHIS414
AHIS262
AHIS263
AHIS333
AHIS414
BHIS262
BHIS263

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:27152332, ECO:0007744|PDB:4ZEL
ChainResidueDetails
AHIS412
AMET487
BHIS412
BMET487

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27152332, ECO:0007744|PDB:4ZEL
ChainResidueDetails
AASN566
BASN64
BASN344
BASN566
AASN64
AASN344

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:27152332, ECO:0007744|PDB:4ZEL
ChainResidueDetails
AASN184
BASN184

218500

PDB entries from 2024-04-17

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