4ZEL

Human dopamine beta-hydroxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0004500	molecular_function	dopamine beta-monooxygenase activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006589	biological_process	octopamine biosynthetic process
A	0007268	biological_process	chemical synaptic transmission
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016715	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031418	molecular_function	L-ascorbic acid binding
A	0034466	cellular_component	chromaffin granule lumen
A	0034774	cellular_component	secretory granule lumen
A	0042420	biological_process	dopamine catabolic process
A	0042421	biological_process	norepinephrine biosynthetic process
A	0042423	biological_process	catecholamine biosynthetic process
A	0042584	cellular_component	chromaffin granule membrane
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0003824	molecular_function	catalytic activity
B	0004497	molecular_function	monooxygenase activity
B	0004500	molecular_function	dopamine beta-monooxygenase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006589	biological_process	octopamine biosynthetic process
B	0007268	biological_process	chemical synaptic transmission
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016715	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
B	0030658	cellular_component	transport vesicle membrane
B	0030667	cellular_component	secretory granule membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031418	molecular_function	L-ascorbic acid binding
B	0034466	cellular_component	chromaffin granule lumen
B	0034774	cellular_component	secretory granule lumen
B	0042420	biological_process	dopamine catabolic process
B	0042421	biological_process	norepinephrine biosynthetic process
B	0042423	biological_process	catecholamine biosynthetic process
B	0042584	cellular_component	chromaffin granule membrane
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0120162	biological_process	positive regulation of cold-induced thermogenesis

Functional Information from PROSITE/UniProt

site_id	PS00084
Number of Residues	8
Details	CU2_MONOOXYGENASE_1 Copper type II, ascorbate-dependent monooxygenases signature 1. HHMevFqC

Chain	Residue	Details
A	HIS262-CYS269

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site_id	PS00085
Number of Residues	13
Details	CU2_MONOOXYGENASE_2 Copper type II, ascorbate-dependent monooxygenases signature 2. HiFasqlHTHltG

Chain	Residue	Details
A	HIS405-GLY417

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27152332","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27152332","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZEL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27152332","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZEL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27152332","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZEL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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