PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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7A5O	Human MUC2 AAs 21-1397 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Javitt, G, Khmelnitsky, L, Albert, L, Elad, N, Ilani, T, Diskin, R, Fass, D. 登録日 2020-08-21 公開日 2020-10-21 最終更新日 2020-11-11 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Assembly Mechanism of Mucin and von Willebrand Factor Polymers. Cell, 183, 2020
7U2J	Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S. 登録日 2022-02-24 公開日 2022-07-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine. Nucleic Acids Res., 50, 2022
6Q9L	HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 9 AT 1.13A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, [6-chloranyl-3-[3-[[4-chloranyl-2-(hydroxymethyl)phenyl]methyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]-[(3~{S})-3-[3-(dimethylamino)propyl-methyl-amino]pyrrolidin-1-yl]methanone 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6Q9U	HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 12 AT 2.4A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-[(4~{S})-5-(5-chloranyl-2-oxidanylidene-1~{H}-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxy-pyrimidin-5-yl]-6-oxidanylidene-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-4-yl]benzenecarbonitrile, CHLORIDE ION, ... 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6ZYA	Extended human uromodulin filament core at 3.5 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. 登録日 2020-07-31 公開日 2020-09-02 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Elife, 9, 2020
7U2I	Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S. 登録日 2022-02-24 公開日 2022-07-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine. Nucleic Acids Res., 50, 2022
6PYW	Crystal Structure of HLA-B*2705-W60A in complex with LRN, a self-peptide 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-27 alpha chain, ... 著者 Gras, S. 登録日 2019-07-31 公開日 2019-11-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation. J.Biol.Chem., 294, 2019
6BSW	Crystal structure of Xyloglucan Xylosyltransferase 1 ternary form 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MANGANESE (II) ION, ... 著者 Culbertson, A.T, Ehrlich, J.J, Choe, J, Honzatko, R.B, Zabotina, O.A. 登録日 2017-12-04 公開日 2018-05-23 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (2.156 Å) 主引用文献 Structure of xyloglucan xylosyltransferase 1 reveals simple steric rules that define biological patterns of xyloglucan polymers. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1N2L	Crystal structure of a covalent intermediate of endogenous human arylsulfatase A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARYLSULFATASE A, ... 著者 Chruszcz, M, Laidler, P, Monkiewicz, M, Ortlund, E, Lebioda, L, Lewinski, K. 登録日 2002-10-23 公開日 2003-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of a covalent intermediate of endogenous human arylsulfatase A. J.Inorg.Biochem., 96, 2003
6NT3	Cryo-EM structure of a human-cockroach hybrid Nav channel. 分子名称: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Clairfeuille, T, Rohou, A, Payandeh, J. 登録日 2019-01-28 公開日 2019-02-20 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2. Science, 2019
7PJE	Inhibiting parasite proliferation using a rationally designed anti-tubulin agent 分子名称: Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. 登録日 2021-08-24 公開日 2021-09-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
6Q8H	Structure of Fucosylated D-antimicrobial peptide SB10 in complex with the Fucose-binding lectin PA-IIL at 1.707 Angstrom resolution 分子名称: 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, AMINO GROUP, CALCIUM ION, ... 著者 Baeriswyl, S, Stocker, A, Reymond, J.L. 登録日 2018-12-14 公開日 2019-03-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.707 Å) 主引用文献 X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. Acs Chem.Biol., 14, 2019
6Q9O	HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 10 AT 1.21A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: E3 ubiquitin-protein ligase Mdm2, ~{N}-~{tert}-butyl-2-[4-chloranyl-2-[5-(3-chloranyl-4-fluoranyl-phenyl)-2-cyclohexyl-4-(1~{H}-1,2,3,4-tetrazol-5-yl)imidazol-1-yl]phenyl]ethanamide 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6Q9Q	HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 13 AT 2.1A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-(4-cyclohexylpiperazin-1-yl)ethyl]-1~{H}-indole-2-carboxamide, GLYCEROL, ... 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
7PD9	Crystal structure of CD73 in complex with riboflavin in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-04 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PCP	Crystal structure of CD73 in complex with 5-iodouracil in the open form 分子名称: 5'-nucleotidase, 5-IODOURACIL, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-03 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
6XHW	Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. 登録日 2020-06-19 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
6PZQ	Structure of the human respiratory syncytial virus M2-1 protein in complex with a short positive-sense gene-end RNA 分子名称: Matrix M2-1, RNA (5'-R(P*GP*UP*UP*AP*AP*U)-3'), ZINC ION 著者 Gao, Y, Cao, D, Liang, B. 登録日 2019-08-01 公開日 2020-08-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.703 Å) 主引用文献 Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA. Structure, 28, 2020
5FEC	Crystal structure of 3BNC60 Fab germline precursor in complex with 426c.TM4deltaV1-3 gp120 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 426c.TM4deltaV1-3 gp120, ... 著者 Scharf, L, Bjorkman, P.J. 登録日 2015-12-16 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 Structural basis for germline antibody recognition of HIV-1 immunogens. Elife, 5, 2016
6XQE	Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Batool, Z, Lomakin, I.B, Bunick, C.G, Polikanov, Y.S. 登録日 2020-07-09 公開日 2020-08-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 117, 2020
6Q9W	X-ray structure of compound 15 bound to HdmX: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: (4~{S})-4-(4-chlorophenyl)-5-[(1~{S})-1-(3-chlorophenyl)ethyl]-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Protein Mdm4, ... 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6Q7A	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 4 AT 2.2A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: 1-[2,6-bis(chloranyl)phenyl]-2-(furan-2-yl)-5-methyl-4-(phenylmethyl)imidazole, Nuclear receptor ROR-gamma 著者 Kallen, J. 登録日 2018-12-13 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019
6H15	Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Gros, P, van Scherpenzeel, R.C. 登録日 2018-07-11 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells. Nat Commun, 10, 2019
6NM6	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to N6 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.2 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ... 著者 Lai, Y.-T, Kwong, P.D. 登録日 2019-01-10 公開日 2019-02-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.739 Å) 主引用文献 Improvement of antibody functionality by structure-guided paratope engraftment. Nat Commun, 10, 2019
6PT5	Crystal Structure of Class D Beta-lactamase OXA-48 with Cefoxitin 分子名称: (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, Class D Carbapenemase OXA-48 著者 Akhtar, A, Chen, Y. 登録日 2019-07-14 公開日 2020-01-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020

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