6NT3

Cryo-EM structure of a human-cockroach hybrid Nav channel.

Summary for 6NT3

• Entry DOI: 10.2210/pdb6nt3/pdb
• EMDB information: 0500
• Descriptor: Sodium channel protein type 9 subunit alpha, Sodium channel protein PaFPC1, chimeric construct, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: sodium channel, scorpion toxin, electrical signaling, fast inactivation, membrane protein
• Biological source: Periplaneta americana (American cockroach); More
• Total number of polymer chains: 1
• Total formula weight: 186815.19

Authors

Clairfeuille, T.,Rohou, A.,Payandeh, J. (deposition date: 2019-01-28, release date: 2019-02-20, Last modification date: 2025-05-28)

• Primary citation: Clairfeuille, T.,Rohou, A.,Payandeh, J.; Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2.; Science, 2019

Experimental method

ELECTRON MICROSCOPY (3.4 Å)