6NT3
Cryo-EM structure of a human-cockroach hybrid Nav channel.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 9 subunit alpha, Sodium channel protein PaFPC1, chimeric construct | polymer | 1559 | 178763.7 | 1 | UniProt (D0E0C2) UniProt (Q15858) Pfam (PF00520) | Periplaneta americana (American cockroach) | PaFPC1,NavPaS,Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7,PaFPC1,NavPaS |
| 2 | B (B) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G61217QH) | |||
| 3 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | E, F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | I (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 6 | J, K, L, M (A) | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate | non-polymer | 742.0 | 4 | Chemie (76F) PubChem (53479626) PubChem (76042081) PubChem (134768091) PubChem (156587308) PubChem (162806467) | |||
| 7 | N (A) | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE | non-polymer | 723.0 | 1 | Chemie (LHG) PubChem (446440) PubChem (9547104) PubChem (11846227) PubChem (46936292) PubChem (65144) PubChem (13305396) PubChem (73416066) PubChem (138986743) | |||
| 8 | O (A) | Digitonin | non-polymer | 1229.3 | 1 | Chemie (AJP) |
Sequence modifications
A: 1 - 1154 (UniProt: D0E0C2)
A: 1155 - 1286 (UniProt: Q15858)
A: 1287 - 1505 (UniProt: D0E0C2)
| PDB | External Database | Details |
|---|---|---|
| Trp -53 | - | expression tag |
| Ser -52 | - | expression tag |
| His -51 | - | expression tag |
| Pro -50 | - | expression tag |
| Gln -49 | - | expression tag |
| Phe -48 | - | expression tag |
| Glu -47 | - | expression tag |
| Lys -46 | - | expression tag |
| Gly -45 | - | expression tag |
| Gly -44 | - | expression tag |
| Gly -43 | - | expression tag |
| Ser -42 | - | expression tag |
| Gly -41 | - | expression tag |
| Gly -40 | - | expression tag |
| Gly -39 | - | expression tag |
| Ser -38 | - | expression tag |
| Gly -37 | - | expression tag |
| Gly -36 | - | expression tag |
| Ser -35 | - | expression tag |
| Ala -34 | - | expression tag |
| Trp -33 | - | expression tag |
| Ser -32 | - | expression tag |
| His -31 | - | expression tag |
| Pro -30 | - | expression tag |
| Gln -29 | - | expression tag |
| Phe -28 | - | expression tag |
| Glu -27 | - | expression tag |
| Lys -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Tyr -19 | - | expression tag |
| Lys -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Lys -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Ser 270 | Phe 270 | conflict |
| Leu 274 | Val 274 | conflict |
| Ile 275 | Leu 275 | conflict |
| Leu 279 | Ile 279 | conflict |
| Phe 280 | Tyr 280 | conflict |
| Asn 283 | Val 283 | conflict |
| Lys 285 | Thr 285 | conflict |
| His 286 | Gln 286 | conflict |
A: 1287 - 1505 (UniProt: D0E0C2)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 178763.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1759.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 6291.9 | |
| All* | Total formula weight | 186815.2 |
