PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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6SAH	Crystal Structure of BRD4(1) bound to inhibitor BUX5 (11) 分子名称: Bromodomain-containing protein 4, ~{N}-(2-methoxy-5-piperidin-1-ylsulfonyl-phenyl)-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide 著者 Huegle, M. 登録日 2019-07-16 公開日 2020-12-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J.Med.Chem., 63, 2020
6F9Y	Lysozyme crystallized in presence of 10 mM lithium sulphate at pH 4.5 分子名称: CHLORIDE ION, Lysozyme C, SULFATE ION 著者 Camara-Artigas, A. 登録日 2017-12-15 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Orthorhombic lysozyme crystallization at acidic pH values driven by phosphate binding. Acta Crystallogr D Struct Biol, 74, 2018
6V0N	PRMT5 bound to PBM peptide from Riok1 分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ... 著者 McMIllan, B.J, Raymond, D.D. 登録日 2019-11-19 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6SKB	Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK3496783A 分子名称: 4-[(3~{R})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, 4-[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, ... 著者 Thorpe, J.H. 登録日 2019-08-15 公開日 2019-09-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorg.Med.Chem.Lett., 29, 2019
8CZH	Human BAK in complex with the dM2 peptide 分子名称: Bcl-2 homologous antagonist/killer, DM2 peptide 著者 Aguilar, F, Keating, A.E. 登録日 2022-05-24 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure, 31, 2023
6F2N	Crystal structure of BCII Metallo-beta-lactamase in complex with KDU197 分子名称: (~{Z})-3-[2-(naphthalen-2-ylmethyl)phenyl]-2-sulfanyl-prop-2-enoic acid, Metallo-beta-lactamase type 2, SULFATE ION, ... 著者 McDonough, M.A, El-Hussein, A, Schofield, C.J, Zhang, D, Brem, J. 登録日 2017-11-24 公開日 2018-10-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.149 Å) 主引用文献 Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Bioorg. Med. Chem., 26, 2018
6F7Y	Crystal structure of dimethylated RSL, cucurbituril-free form 分子名称: Fucose-binding lectin protein, GLYCEROL 著者 Guagnini, F, Rennie, M.L, Crowley, P.B. 登録日 2017-12-12 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Cucurbit[7]uril-Dimethyllysine Recognition in a Model Protein. Angew. Chem. Int. Ed. Engl., 57, 2018
6S93	Crystal structure of group B of Usutu virus envelope protein domain III 分子名称: Genome polyprotein 著者 Schoenenwald, A.K.J, Skern, T. 登録日 2019-07-11 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structural and antigenic investigation of Usutu virus envelope protein domain III. Virology, 551, 2020
6SA9	Endogenous Retrovirus HML2 Capsid NTD 分子名称: Endogenous retrovirus group K member 9 Pol protein, GLYCEROL 著者 Goldstone, D.C, Ball, N.J, Taylor, I.A. 登録日 2019-07-16 公開日 2020-01-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for Fullerene geometry in a human endogenous retrovirus capsid. Nat Commun, 10, 2019
6V4C	Culex quinquefasciatus D7 long form 1- CxD7L1 in complex with ADP 分子名称: 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Calvo, E, Garboczi, D.N, Martin-Martin, I, Gittis, A.G. 登録日 2019-11-27 公開日 2020-06-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 ADP binding by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals. Nat Commun, 11, 2020
6V94	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 1-[(4-fluorophenyl)methyl]-2-methyl-4-nitro-1H-imidazole, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6SD8	Bd2924 apo-form 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Probable acyl-CoA dehydrogenase 著者 Lovering, A.L, Harding, C.J. 登録日 2019-07-26 公開日 2019-09-11 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins, 87, 2019
6SDA	Bd2924 C10 acyl-coenzymeA bound form 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Probable acyl-CoA dehydrogenase, decanoyl-CoA 著者 Lovering, A.L, Harding, C.J. 登録日 2019-07-26 公開日 2019-09-11 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins, 87, 2019
8DGD	Crystal Structure of GAF domain-containing protein, from Klebsiella pneumoniae 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GAF domain-containing protein, ZINC ION 著者 Seattle Structural Genomics Center for Infectious Disease, Delker, S.L, Weiss, M.J, Lorimer, D.D, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-06-23 公開日 2023-03-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of GAF domain-containing protein, from Klebsiella pneumoniae to be published
6F1H	C1rC1s complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Almitairi, J.O.M, Venkatraman Girija, U, Furze, C.M, Simpson-Gray, X, Badakshi, F, Marshall, J.E, Mitchell, D.A, Moody, P.C.E, Wallis, R. 登録日 2017-11-22 公開日 2018-01-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Structure of the C1r-C1s interaction of the C1 complex of complement activation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8T8C	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. 登録日 2023-06-22 公開日 2023-07-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
6F1P	Tetragonal Lysozyme crystallized at 298 K and pH 4.5 with phosphate bound 分子名称: CHLORIDE ION, Lysozyme C, PHOSPHATE ION, ... 著者 Camara-Artigas, A. 登録日 2017-11-22 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Orthorhombic lysozyme crystallization at acidic pH values driven by phosphate binding. Acta Crystallogr D Struct Biol, 74, 2018
8T8B	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. 登録日 2023-06-22 公開日 2023-07-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
8TTJ	Tryptophan-6-halogenase BorH complexed with 6-chlorotryptophan 分子名称: 6-CHLORO-L-TRYPTOPHAN, SULFATE ION, Tryptophan 6-halogenase 著者 Lingkon, K, Bellizzi, J.J. 登録日 2023-08-14 公開日 2023-08-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Crystallographic and thermodynamic evidence of negative cooperativity of flavin and tryptophan binding in the flavin-dependent halogenases AbeH and BorH. Biorxiv, 2023
8DJ7	The complex structure between human IgG1 Fc and its high affinity receptor FcgRI H174R variant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin gamma Fc receptor I, Ig gamma-1 Fc chain, ... 著者 Lu, J, Sun, P.D. 登録日 2022-06-30 公開日 2023-05-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Fc gamma RI FG-loop functions as a pH sensitive switch for IgG binding and release. Front Immunol, 14, 2023
6F9Z	Lysozyme crystallized in presence of 5 mM ammonium sulphate at pH 4.5 分子名称: CHLORIDE ION, Lysozyme C, SULFATE ION 著者 Camara-Artigas, A. 登録日 2017-12-15 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Orthorhombic lysozyme crystallization at acidic pH values driven by phosphate binding. Acta Crystallogr D Struct Biol, 74, 2018
6FAL	Tryptophan Repressor TrpR from E.coli with 3-Indolepropionic acid as ligand 分子名称: INDOLYLPROPIONIC ACID, Trp operon repressor 著者 Stiel, A.C, Shanmugaratnam, S, Hocker, B. 登録日 2017-12-15 公開日 2019-01-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Tryptophan Repressor TrpR from E.coli: A ligand binding study To Be Published
6FAU	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma 分子名称: (2~{R})-2-[(~{R})-(2-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-18 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6FI4	Crystal structure of C-terminal modified Tau peptide-hybrid 3.2e with 14-3-3sigma 分子名称: (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2018-01-17 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6FCA	Catalytic subunit HisG from Psychrobacter arcticus ATP phosphoribosyltransferase (HisZG ATPPRT) in complex with PRPP 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ATP phosphoribosyltransferase 著者 Alphey, M.S, Ge, Y, Fisher, G, Czekster, C.M, Naismith, J.H, da Silva, R.G. 登録日 2017-12-20 公開日 2018-10-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Catalytic and Anticatalytic Snapshots of a Short-Form ATP Phosphoribosyltransferase Acs Catalysis, 2018

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