1STC
 
 | CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE | 分子名称: | CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, STAUROSPORINE | 著者 | Prade, L, Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D. | 登録日 | 1997-10-10 | 公開日 | 1998-02-25 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. Structure, 5, 1997
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4K0T
 
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2GEB
 
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5APN
 
 | Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1 | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Greber, B.J, Gerhardy, S, Leitner, A, Leibundgut, M, Salem, M, Boehringer, D, Leulliot, N, Aebersold, R, Panse, V.G, Ban, V. | 登録日 | 2015-09-17 | 公開日 | 2015-12-16 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation. Cell, 164, 2015
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2C2U
 
 | Dps from Deinococcus radiodurans | 分子名称: | DNA-BINDING STRESS RESPONSE PROTEIN, FE (III) ION, SULFATE ION, ... | 著者 | Romao, C.V, Mitchell, E, McSweeney, S. | 登録日 | 2005-09-30 | 公開日 | 2006-07-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | The Crystal Structure of Deinococcus Radiodurans Dps Protein (Dr2263) Reveals the Presence of a Novel Metal Centre in the N Terminus. J.Biol.Inorg.Chem., 11, 2006
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1SVG
 
 | Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4 | 分子名称: | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ALPHA FORM, N-{(3R,4R)-4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZOYLAMINO]-AZEPAN-3-YL}ISONICOTINAMIDE, ... | 著者 | Breitenlechner, C.B, Wegge, T, Berillon, L, Graul, K, Marzenell, K, Friebe, W.-G, Thomas, U, Schumacher, R, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-03-29 | 公開日 | 2005-03-29 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structure-based optimization of novel azepane derivatives as PKB inhibitors J.Med.Chem., 47, 2004
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3HCG
 
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2GIN
 
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6URC
 
 | Crystal structure of IRE1a in complex with compound 18 | 分子名称: | 2-chloro-N-(6-methyl-5-{[3-(2-{[(3S)-piperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}naphthalen-1-yl)benzene-1-sulfonamide, GLYCEROL, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Wallweber, H.H, Wang, W. | 登録日 | 2019-10-23 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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2G46
 
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1T2K
 
 | Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA | 分子名称: | 31-MER, Cyclic-AMP-dependent transcription factor ATF-2, Interferon regulatory factor 3, ... | 著者 | Panne, D, Maniatis, T, Harrison, S.C. | 登録日 | 2004-04-21 | 公開日 | 2004-11-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. Embo J., 23, 2004
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3H5J
 
 | LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, 3-isopropylmalate dehydratase small subunit, SULFATE ION | 著者 | Manikandan, K, Geerlof, A, Weiss, M.S. | 登録日 | 2009-04-22 | 公開日 | 2010-04-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis Proteins, 79, 2011
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4KBO
 
 | Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form | 分子名称: | SODIUM ION, Stress-70 protein, mitochondrial | 著者 | Amick, J, Page, R.C, Nix, J.C, Misra, S. | 登録日 | 2013-04-23 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. Protein Sci., 23, 2014
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1BZL
 
 | CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS | 分子名称: | BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, FLAVIN-ADENINE DINUCLEOTIDE, TRYPANOTHIONE REDUCTASE (OXIDIZED FORM) | 著者 | Bond, C.S, Zhang, Y, Berriman, M, Cunningham, M, Fairlamb, A.H, Hunter, W.N. | 登録日 | 1998-11-02 | 公開日 | 1999-11-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors. Structure Fold.Des., 7, 1999
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6JHN
 
 | Structure of RyR2 (F/C/Ca2+ dataset) | 分子名称: | CAFFEINE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | 登録日 | 2019-02-18 | 公開日 | 2019-12-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc.Natl.Acad.Sci.USA, 116, 2019
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3RIK
 
 | The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease | 分子名称: | (3S,4R,5R,6S)-1-(2-hydroxyethyl)azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ... | 著者 | Orwig, S.D, Lieberman, R.L. | 登録日 | 2011-04-13 | 公開日 | 2012-03-14 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Biochemistry, 50, 2011
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2BK6
 
 | The X-ray crystal structure of the Listeria innocua H31G Dps mutant. | 分子名称: | NON-HEME IRON-CONTAINING FERRITIN | 著者 | Ilari, A, Latella, M.C, Ribacchi, F, Su, M, Giangiacomo, L, Stefanini, S, Chasteen, N.D, Chiancone, E. | 登録日 | 2005-02-11 | 公開日 | 2005-02-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | The unusual intersubunit ferroxidase center of Listeria innocua Dps is required for hydrogen peroxide detoxification but not for iron uptake. A study with site-specific mutants. Biochemistry, 44, 2005
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4BY7
 
 | elongating RNA Polymerase II-Bye1 TLD complex | 分子名称: | , 5'-D(*DAP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*DTP)-3', 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Kinkelin, K, Wozniak, G.G, Rothbart, S.B, Lidschreiber, M, Strahl, B.D, Cramer, P. | 登録日 | 2013-07-18 | 公開日 | 2013-09-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
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1C3P
 
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4KLL
 
 | DNA polymerase beta matched product complex with Mg2+, 45 min | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.841 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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4KLU
 
 | DNA polymerase beta mismatched product complex with Mn2+, 15 h | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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3MBP
 
 | MALTODEXTRIN-BINDING PROTEIN WITH BOUND MALTOTRIOSE | 分子名称: | MALTODEXTRIN-BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Spurlino, J.C, Quiocho, F.A. | 登録日 | 1997-06-25 | 公開日 | 1997-12-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor. Structure, 5, 1997
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6UZH
 
 | Cryo-EM structure of mechanosensitive channel MscS reconstituted into peptidiscs | 分子名称: | Small-conductance mechanosensitive channel | 著者 | Angiulli, G, Walz, T, Dhupar, H.S, Suzuki, H, Wason, I.S, Duong Van Hoa, F. | 登録日 | 2019-11-15 | 公開日 | 2020-03-04 | 最終更新日 | 2025-05-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins. Elife, 9, 2020
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6S2J
 
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3R60
 
 | Structure of the MntR Fe2+ Complex | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FE (II) ION, S-1,2-PROPANEDIOL, ... | 著者 | Glasfeld, A, Brophy, M.B, Kliegman, J.I, Griner, S.L, Nix, J.C. | 登録日 | 2011-03-20 | 公開日 | 2012-04-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Roles of the A and C Sites in the Manganese-Specific Activation of MntR. Biochemistry, 52, 2013
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