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1STC
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BU of 1stc by Molmil
CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE
分子名称: CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, STAUROSPORINE
著者Prade, L, Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D.
登録日1997-10-10
公開日1998-02-25
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.
Structure, 5, 1997
4K0T
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BU of 4k0t by Molmil
Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide
分子名称: 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
著者Biswas, S, McKenna, R.
登録日2013-04-04
公開日2014-04-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Designing isoform specific inhibitors against hCAIX using CAIX mimic
To be Published
2GEB
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BU of 2geb by Molmil
Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design
分子名称: CALCIUM ION, Hypoxanthine-guanine phosphoribosyltransferase
著者Chen, Q, Luo, M.
登録日2006-03-19
公開日2007-04-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
Febs J., 274, 2007
5APN
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BU of 5apn by Molmil
Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1
分子名称: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Greber, B.J, Gerhardy, S, Leitner, A, Leibundgut, M, Salem, M, Boehringer, D, Leulliot, N, Aebersold, R, Panse, V.G, Ban, V.
登録日2015-09-17
公開日2015-12-16
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.
Cell, 164, 2015
2C2U
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BU of 2c2u by Molmil
Dps from Deinococcus radiodurans
分子名称: DNA-BINDING STRESS RESPONSE PROTEIN, FE (III) ION, SULFATE ION, ...
著者Romao, C.V, Mitchell, E, McSweeney, S.
登録日2005-09-30
公開日2006-07-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The Crystal Structure of Deinococcus Radiodurans Dps Protein (Dr2263) Reveals the Presence of a Novel Metal Centre in the N Terminus.
J.Biol.Inorg.Chem., 11, 2006
1SVG
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BU of 1svg by Molmil
Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4
分子名称: CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ALPHA FORM, N-{(3R,4R)-4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZOYLAMINO]-AZEPAN-3-YL}ISONICOTINAMIDE, ...
著者Breitenlechner, C.B, Wegge, T, Berillon, L, Graul, K, Marzenell, K, Friebe, W.-G, Thomas, U, Schumacher, R, Huber, R, Engh, R.A, Masjost, B.
登録日2004-03-29
公開日2005-03-29
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structure-based optimization of novel azepane derivatives as PKB inhibitors
J.Med.Chem., 47, 2004
3HCG
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BU of 3hcg by Molmil
Structure of the C-terminal domain (MsrB) of Neisseria meningitidis PilB (reduced form)
分子名称: PHOSPHATE ION, Peptide methionine sulfoxide reductase msrA/msrB
著者Ranaivoson, F.M, Kauffmann, B, Favier, F.
登録日2009-05-06
公開日2009-10-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Methionine sulfoxide reductase B displays a high level of flexibility.
J.Mol.Biol., 394, 2009
2GIN
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BU of 2gin by Molmil
X-ray structure of the wt allene oxide cyclase 2 from arabidopsis thaliana
分子名称: Allene oxide cyclase 2, GLYCEROL, SODIUM ION
著者Hofmann, E, Schaller, F, Zerbe, P.
登録日2006-03-29
公開日2006-11-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Crystal Structure of Arabidopsis thaliana Allene Oxide Cyclase: Insights into the Oxylipin Cyclization Reaction
Plant Cell, 18, 2006
6URC
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BU of 6urc by Molmil
Crystal structure of IRE1a in complex with compound 18
分子名称: 2-chloro-N-(6-methyl-5-{[3-(2-{[(3S)-piperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}naphthalen-1-yl)benzene-1-sulfonamide, GLYCEROL, Serine/threonine-protein kinase/endoribonuclease IRE1
著者Wallweber, H.H, Wang, W.
登録日2019-10-23
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
2G46
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BU of 2g46 by Molmil
structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH
分子名称: PBCV-1 histone H3-Lys 27 methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, meK27 H3 Peptide
著者Qian, C.M, Zheng, L, Zhou, M.M.
登録日2006-02-21
公開日2006-12-05
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.
J.Mol.Biol., 359, 2006
1T2K
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BU of 1t2k by Molmil
Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
分子名称: 31-MER, Cyclic-AMP-dependent transcription factor ATF-2, Interferon regulatory factor 3, ...
著者Panne, D, Maniatis, T, Harrison, S.C.
登録日2004-04-21
公開日2004-11-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.
Embo J., 23, 2004
3H5J
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BU of 3h5j by Molmil
LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis
分子名称: 1,2-ETHANEDIOL, 3-isopropylmalate dehydratase small subunit, SULFATE ION
著者Manikandan, K, Geerlof, A, Weiss, M.S.
登録日2009-04-22
公開日2010-04-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis
Proteins, 79, 2011
4KBO
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BU of 4kbo by Molmil
Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form
分子名称: SODIUM ION, Stress-70 protein, mitochondrial
著者Amick, J, Page, R.C, Nix, J.C, Misra, S.
登録日2013-04-23
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.
Protein Sci., 23, 2014
1BZL
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BU of 1bzl by Molmil
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS
分子名称: BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, FLAVIN-ADENINE DINUCLEOTIDE, TRYPANOTHIONE REDUCTASE (OXIDIZED FORM)
著者Bond, C.S, Zhang, Y, Berriman, M, Cunningham, M, Fairlamb, A.H, Hunter, W.N.
登録日1998-11-02
公開日1999-11-10
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Structure Fold.Des., 7, 1999
6JHN
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BU of 6jhn by Molmil
Structure of RyR2 (F/C/Ca2+ dataset)
分子名称: CAFFEINE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N.
登録日2019-02-18
公開日2019-12-11
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
Proc.Natl.Acad.Sci.USA, 116, 2019
3RIK
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BU of 3rik by Molmil
The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
分子名称: (3S,4R,5R,6S)-1-(2-hydroxyethyl)azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ...
著者Orwig, S.D, Lieberman, R.L.
登録日2011-04-13
公開日2012-03-14
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease
Biochemistry, 50, 2011
2BK6
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BU of 2bk6 by Molmil
The X-ray crystal structure of the Listeria innocua H31G Dps mutant.
分子名称: NON-HEME IRON-CONTAINING FERRITIN
著者Ilari, A, Latella, M.C, Ribacchi, F, Su, M, Giangiacomo, L, Stefanini, S, Chasteen, N.D, Chiancone, E.
登録日2005-02-11
公開日2005-02-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献The unusual intersubunit ferroxidase center of Listeria innocua Dps is required for hydrogen peroxide detoxification but not for iron uptake. A study with site-specific mutants.
Biochemistry, 44, 2005
4BY7
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BU of 4by7 by Molmil
elongating RNA Polymerase II-Bye1 TLD complex
分子名称: , 5'-D(*DAP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*DTP)-3', 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Kinkelin, K, Wozniak, G.G, Rothbart, S.B, Lidschreiber, M, Strahl, B.D, Cramer, P.
登録日2013-07-18
公開日2013-09-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
1C3P
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BU of 1c3p by Molmil
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS
分子名称: PROTEIN (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN))
著者Finnin, M.S, Donigian, J.R, Pavletich, N.P.
登録日1999-07-28
公開日1999-09-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
4KLL
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BU of 4kll by Molmil
DNA polymerase beta matched product complex with Mg2+, 45 min
分子名称: 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
著者Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H.
登録日2013-05-07
公開日2013-07-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.841 Å)
主引用文献Observing a DNA polymerase choose right from wrong.
Cell(Cambridge,Mass.), 154, 2013
4KLU
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BU of 4klu by Molmil
DNA polymerase beta mismatched product complex with Mn2+, 15 h
分子名称: 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
著者Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H.
登録日2013-05-07
公開日2013-07-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Observing a DNA polymerase choose right from wrong.
Cell(Cambridge,Mass.), 154, 2013
3MBP
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BU of 3mbp by Molmil
MALTODEXTRIN-BINDING PROTEIN WITH BOUND MALTOTRIOSE
分子名称: MALTODEXTRIN-BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Spurlino, J.C, Quiocho, F.A.
登録日1997-06-25
公開日1997-12-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
6UZH
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BU of 6uzh by Molmil
Cryo-EM structure of mechanosensitive channel MscS reconstituted into peptidiscs
分子名称: Small-conductance mechanosensitive channel
著者Angiulli, G, Walz, T, Dhupar, H.S, Suzuki, H, Wason, I.S, Duong Van Hoa, F.
登録日2019-11-15
公開日2020-03-04
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins.
Elife, 9, 2020
6S2J
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BU of 6s2j by Molmil
Square conformation of KtrA R16K mutant ring with bound ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, MAGNESIUM ION
著者Teixeira-Duarte, C.M, Fonseca, F, Morais-Cabral, J.H.
登録日2019-06-21
公開日2020-01-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site.
Elife, 8, 2019
3R60
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Structure of the MntR Fe2+ Complex
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FE (II) ION, S-1,2-PROPANEDIOL, ...
著者Glasfeld, A, Brophy, M.B, Kliegman, J.I, Griner, S.L, Nix, J.C.
登録日2011-03-20
公開日2012-04-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013

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