2GEB

Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design

Summary for 2GEB

• Entry DOI: 10.2210/pdb2geb/pdb
• Related: 1R3U 1YFZ
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, CALCIUM ION (3 entities in total)
• Functional Keywords: hgprt, mutant, inhibitor design, selectivity, transferase
• Biological source: Thermoanaerobacter tengcongensis
• Total number of polymer chains: 1
• Total formula weight: 20849.40

Authors

Chen, Q.,Luo, M. (deposition date: 2006-03-19, release date: 2007-04-03, Last modification date: 2024-02-14)

• Primary citation: Chen, Q.,You, D.,Liang, Y.,Su, X.,Gu, X.,Luo, M.,Zheng, X.; Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.; Febs J., 274:4408-4415, 2007; PubMed: 17662107; DOI: 10.1111/j.1742-4658.2007.05970.x

Experimental method

X-RAY DIFFRACTION (1.7 Å)