2GEB

Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hypoxanthine-guanine phosphoribosyltransferase	polymer	185	20769.2	1	GenBank (20517402) Pfam (PF00156) UniProt (by SIFTS) (Q8R7L0) In PDB	Thermoanaerobacter tengcongensis
2	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3		water	water		18.0	187	Chemie (HOH)

Sequence modifications

A: 1 - 181 (GenBank: 20517402)

PDB	External Database	Details
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Gly 53	Asp 53	engineered mutation
Leu 67	Met 67	engineered mutation
Ile 160	Leu 160	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20769.2
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	20849.4

*Water molecules are not included.