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2GEB

Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0004422molecular_functionhypoxanthine phosphoribosyltransferase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006166biological_processpurine ribonucleoside salvage
A0006178biological_processguanine salvage
A0016757molecular_functionglycosyltransferase activity
A0032263biological_processGMP salvage
A0032264biological_processIMP salvage
A0046100biological_processhypoxanthine metabolic process
A0046872molecular_functionmetal ion binding
A0052657molecular_functionguanine phosphoribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 201
ChainResidue
AGLU101
AASP102
AHOH261
AHOH321
AHOH328
AHOH349

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 202
ChainResidue
AHOH249
AHOH260
AHOH388
AASP7
AGLU135
AHOH248

Functional Information from PROSITE/UniProt
site_idPS00103
Number of Residues13
DetailsPUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDSGlT
ChainResidueDetails
AVAL97-THR109

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a95
ChainResidueDetails
AASP102
ALYS133
AGLU101
AASP105

site_idCSA2
Number of Residues5
DetailsAnnotated By Reference To The Literature 1a95
ChainResidueDetails
AASP102
ALYS133
AGLU101
AARG137
AASP105

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PDB entries from 2024-07-24

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