1BZL

CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS

Summary for 1BZL

Entry DOI	10.2210/pdb1bzl/pdb
Descriptor	TRYPANOTHIONE REDUCTASE (OXIDIZED FORM), FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, ... (4 entities in total)
Functional Keywords	oxidoreductase, trypanothione reductase, fad dependent disulphide oxidoreductase
Biological source	Trypanosoma cruzi
Total number of polymer chains	2
Total formula weight	109632.76
Authors	Bond, C.S.,Zhang, Y.,Berriman, M.,Cunningham, M.,Fairlamb, A.H.,Hunter, W.N. (deposition date: 1998-11-02, release date: 1999-11-10, Last modification date: 2023-08-09)
Primary citation	Bond, C.S.,Zhang, Y.,Berriman, M.,Cunningham, M.L.,Fairlamb, A.H.,Hunter, W.N. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors. Structure Fold.Des., 7:81-89, 1999 Cited by PubMed: 10368274 DOI: 10.1016/S0969-2126(99)80011-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation