1BCF
 
 | THE STRUCTURE OF A UNIQUE, TWO-FOLD SYMMETRIC, HAEM-BINDING SITE | 分子名称: | BACTERIOFERRITIN, MANGANESE (II) ION, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Frolow, F, Kalb(Gilboa), A.J, Yariv, J. | 登録日 | 1993-12-06 | 公開日 | 1994-12-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of a unique twofold symmetric haem-binding site. Nat.Struct.Biol., 1, 1994
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8EUI
 
 | Ytm1 associated nascent 60S ribosome (-fkbp39) State 3 | 分子名称: | 60S ribosomal protein L10-A, 60S ribosomal protein L11-A, 60S ribosomal protein L13, ... | 著者 | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | 登録日 | 2022-10-18 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8ETH
 
 | Ytm1 associated 60S nascent ribosome State 1B | 分子名称: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | 著者 | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | 登録日 | 2022-10-17 | 公開日 | 2022-11-30 | 最終更新日 | 2025-05-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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7ICG
 
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7ICQ
 
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6W4E
 
 | NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, ... | 著者 | Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. | 登録日 | 2020-03-10 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angew.Chem.Int.Ed.Engl., 59, 2020
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7JMH
 
 | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 35 - State 4 (S4) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... | 著者 | Dashti, A, des Georges, A, Frank, J, Ourmazd, A. | 登録日 | 2020-07-31 | 公開日 | 2020-08-12 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Retrieving functional pathways of biomolecules from single-particle snapshots. Nat Commun, 11, 2020
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6RVF
 
 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-phenyl | 分子名称: | 1-[1,1-bis(oxidanyl)-3~{H}-2,1$l^{4}-benzoxaborol-6-yl]-3-phenyl-urea, Carbonic anhydrase 2, ZINC ION | 著者 | Di Fiore, A, De Simone, G. | 登録日 | 2019-05-31 | 公開日 | 2019-08-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity. J Enzyme Inhib Med Chem, 34, 2019
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4KLJ
 
 | DNA polymerase beta matched product complex with Mg2+, 5 min | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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1RQM
 
 | SOLUTION STRUCTURE OF THE K18G/R82E ALICYCLOBACILLUS ACIDOCALDARIUS THIOREDOXIN MUTANT | 分子名称: | Thioredoxin | 著者 | Leone, M, Di Lello, P, Ohlenschlager, O, Pedone, E.M, Bartolucci, S, Rossi, M, Di Blasio, B, Pedone, C, Saviano, M, Isernia, C, Fattorusso, R. | 登録日 | 2003-12-05 | 公開日 | 2004-06-22 | 最終更新日 | 2024-10-30 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure and Backbone Dynamics of the K18G/R82E Alicyclobacillus acidocaldarius Thioredoxin Mutant: A Molecular Analysis of Its Reduced Thermal Stability. Biochemistry, 43, 2004
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6I2H
 
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3VBD
 
 | Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide | 分子名称: | 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... | 著者 | Mader, P, Brynda, J, Rezacova, P. | 登録日 | 2012-01-02 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55, 2012
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6VYM
 
 | Cryo-EM structure of mechanosensitive channel MscS in PC-18:1 nanodiscs treated with beta-cyclodextran | 分子名称: | Mechanosensitive channel MscS | 著者 | Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T. | 登録日 | 2020-02-27 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Visualization of the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 2021
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6VYL
 
 | Cryo-EM structure of mechanosensitive channel MscS in PC-10 nanodiscs | 分子名称: | Mechanosensitive channel MscS | 著者 | Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T. | 登録日 | 2020-02-27 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Visualization of the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 2021
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4K0R
 
 | Crystal structure of mouse Cryptochrome 1 | 分子名称: | Cryptochrome-1 | 著者 | Czarna, A, Wolf, E. | 登録日 | 2013-04-04 | 公開日 | 2013-06-26 | 最終更新日 | 2024-11-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell(Cambridge,Mass.), 153, 2013
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6VYK
 
 | Cryo-EM structure of mechanosensitive channel MscS in PC-18:1 nanodiscs | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mechanosensitive channel MscS | 著者 | Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T. | 登録日 | 2020-02-27 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Visualization of the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 2021
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7JO3
 
 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide | 分子名称: | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Andring, J.T, McKenna, R. | 登録日 | 2020-08-05 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.454 Å) | 主引用文献 | Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone. J.Med.Chem., 63, 2020
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7ICK
 
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1B82
 
 | PRISTINE RECOMB. LIGNIN PEROXIDASE H8 | 分子名称: | CALCIUM ION, PROTEIN (LIGNIN PEROXIDASE), PROTOPORPHYRIN IX CONTAINING FE | 著者 | Blodig, W, Doyle, W.A, Smith, A.T, Piontek, K. | 登録日 | 1999-02-04 | 公開日 | 1999-02-16 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of pristine and oxidatively processed lignin peroxidase expressed in Escherichia coli and of the W171F variant that eliminates the redox active tryptophan 171. Implications for the reaction mechanism. J.Mol.Biol., 305, 2001
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6S1M
 
 | Human polymerase delta holoenzyme Conformer 1 | 分子名称: | DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... | 著者 | Lancey, C, Hamdan, S.M, De Biasio, A. | 登録日 | 2019-06-19 | 公開日 | 2019-12-25 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
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3GHH
 
 | Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ecto-NAD+ glycohydrolase (CD38 molecule), SULFATE ION, ... | 著者 | Egea, P.F, Muller-Steffner, H, Stroud, R.M, Oppenheimer, N.J, Kellenberger, E, Schuber, F. | 登録日 | 2009-03-03 | 公開日 | 2010-03-16 | 最終更新日 | 2024-11-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Plos One, 7, 2012
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7ICU
 
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4C3I
 
 | Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, ... | 著者 | Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W. | 登録日 | 2013-08-24 | 公開日 | 2013-10-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of the 14-Subunit RNA Polymerase I Nature, 502, 2013
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2FZB
 
 | Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution. | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, aldose reductase | 著者 | Steuber, H, Zentgraf, M, Gerlach, C, Sotriffer, C.A, Heine, A, Klebe, G. | 登録日 | 2006-02-09 | 公開日 | 2006-10-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions. J.Mol.Biol., 363, 2006
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6S66
 
 | Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor | 分子名称: | 1-(2-azanylethyl)-3-(3,4-dichlorophenyl)-~{N}-(phenylmethyl)pyrazole-4-carboxamide, MYRISTIC ACID, Transcriptional enhancer factor TEF-4 | 著者 | Sturbaut, M, Allemand, F, Guichou, J.F. | 登録日 | 2019-07-02 | 公開日 | 2020-07-22 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
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