3VBD
Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide
Summary for 3VBD
| Entry DOI | 10.2210/pdb3vbd/pdb |
| Related | 3V7X |
| Descriptor | Carbonic anhydrase 2, ZINC ION, 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide, ... (6 entities in total) |
| Functional Keywords | lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 30367.24 |
| Authors | Mader, P.,Brynda, J.,Rezacova, P. (deposition date: 2012-01-02, release date: 2012-04-04, Last modification date: 2024-02-28) |
| Primary citation | Gitto, R.,Damiano, F.M.,Mader, P.,De Luca, L.,Ferro, S.,Supuran, C.T.,Vullo, D.,Brynda, J.,Rezacova, P.,Chimirri, A. Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55:3891-3899, 2012 Cited by PubMed: 22443141DOI: 10.1021/jm300112w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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