PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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2B8K	12-subunit RNA Polymerase II 分子名称: DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... 著者 Meyer, P.A, Ye, P, Zhang, M, Suh, M.H, Fu, J. 登録日 2005-10-07 公開日 2006-06-20 最終更新日 2012-06-13 実験手法 X-RAY DIFFRACTION (4.15 Å) 主引用文献 Phasing RNA Polymerase II Using Intrinsically Bound Zn Atoms: An Updated Structural Model. Structure, 14, 2006
2BBP	NMR structures of the peptide linked to the genome (VPg) of poliovirus 分子名称: Genome linked protein VPg 著者 Schein, C.H, Oezguen, N. 登録日 2005-10-17 公開日 2006-03-28 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR structure of the viral peptide linked to the genome (VPg) of poliovirus. Peptides, 27, 2006
2D7S	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with VPg protein 分子名称: RNA-dependent RNA polymerase, VPg1 protein 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2005-11-29 公開日 2006-03-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein 分子名称: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2005-12-02 公開日 2006-03-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
2C8I	Complex Of Echovirus Type 12 With Domains 1, 2, 3 and 4 Of Its Receptor Decay Accelerating Factor (Cd55) By Cryo Electron Microscopy At 16 A 分子名称: COMPLEMENT DECAY-ACCELERATING FACTOR, ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ... 著者 Pettigrew, D.M, Williams, D.T, Kerrigan, D, Evans, D.J, Lea, S.M, Bhella, D. 登録日 2005-12-05 公開日 2006-01-17 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (14 Å) 主引用文献 Structural and Functional Insights Into the Interaction of Echoviruses and Decay-Accelerating Factor. J.Biol.Chem., 281, 2006
2FP7	West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H 分子名称: Genome polyprotein, N-benzoyl-L-norleucyl-L-lysyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-argininamide 著者 Schiering, N, D'Arcy, A, Erbel, P. 登録日 2006-01-16 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nat.Struct.Mol.Biol., 13, 2006
2FQM	Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus 分子名称: Phosphoprotein 著者 Ding, H, Green, T.J, Lu, S, Luo, M. 登録日 2006-01-18 公開日 2006-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus J.Virol., 80, 2006
2FVC	Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone 分子名称: 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one, polyprotein 著者 Concha, N.O, Wonacott, A, Singh, O. 登録日 2006-01-30 公開日 2007-01-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J.Med.Chem., 49, 2006
2GC8	Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase 分子名称: 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE, RNA-directed RNA polymerase 著者 Gopalsamy, A, Chopra, R, Lim, K, Ciszewski, G, Shi, M, Curran, K.J, Sukits, S.F, Svenson, K, Bard, J, Ellingboe, J.W, Agarwal, A, Krishnamurthy, G, Howe, A.Y, Orlowski, M, Feld, B, O'connell, J, Mansour, T.S. 登録日 2006-03-13 公開日 2006-06-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site. J.Med.Chem., 49, 2006
2GIR	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor 分子名称: 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
2GIQ	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-2 inhibitor 分子名称: 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
2CJQ	Bovine viral diarrhea virus CP7-R12 RNA-dependent RNA polymerase 分子名称: RNA-DIRECTED RNA POLYMERASE 著者 Choi, K.H, Gallei, A, Becher, P, Rossmann, M.G. 登録日 2006-04-05 公開日 2006-07-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Structure of Bovine Viral Diarrhea Virus RNA-Dependent RNA Polymerase and its Amino-Terminal Domain. Structure, 14, 2006
2GMO	NMR-structure of an independently folded C-terminal domain of influenza polymerase subunit PB2 分子名称: Polymerase basic protein 2 著者 Boudet, J, Tarendeau, F, Guilligay, D, Mas, P, Bougault, C.M, Cusack, S, Simorre, J.-P, Hart, D.J. 登録日 2006-04-07 公開日 2007-02-27 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat.Struct.Mol.Biol., 14, 2007
2CKW	The 2.3 A resolution structure of the Sapporo virus RNA dependant RNA polymerase. 分子名称: RNA-DIRECTED RNA POLYMERASE 著者 Fullerton, S.W.B, Tucker, P.A, Rohayem, J, Coutard, B, Gebhardt, J, Gorbalenya, A, Canard, B. 登録日 2006-04-24 公開日 2006-11-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase. J.Virol., 81, 2007
2GTT	Crystal structure of the rabies virus nucleoprotein-RNA complex 分子名称: Nucleoprotein, PHOSPHATE ION, RNA (99-MER) 著者 Albertini, A.A.V, Wernimont, A.K, Muziol, T, Ravelli, R.B.G, Weissenhorn, W, Ruigrok, R.W.H. 登録日 2006-04-28 公開日 2006-09-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.49 Å) 主引用文献 Crystal Structure of the Rabies Virus Nucleoprotein-RNA Complex Science, 313, 2006
2H6M	An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors 分子名称: N-ACETYL-LEUCYL-ALANYL-ALANYL-(N,N-DIMETHYL)-GLUTAMINE-(1,4-DIOXO-3,4-DIHYDRO-1H-PHTHALAZIN-2-YL)METHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Picornain 3C 著者 Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. 登録日 2006-05-31 公開日 2006-08-08 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J.Mol.Biol., 361, 2006
2H9H	An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors 分子名称: Hepatitis A virus protease 3C, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Three residue peptide 著者 Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. 登録日 2006-06-09 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors. J.Mol.Biol., 361, 2006
2HAI	Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor. 分子名称: (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE, HEPATITIS C VIRUS NS5B RNA POLYMERASE 著者 Li, H, Love, R.L. 登録日 2006-06-12 公開日 2006-09-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2HCN	Crystal structure of RNA dependent RNA polymerase domain from west nile virus 分子名称: CALCIUM ION, RNA-directed RNA polymerase (NS5), ZINC ION 著者 Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2006-06-17 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
2HCS	Crystal structure of RNA dependant RNA polymerase domain of West Nile virus 分子名称: RNA-directed RNA polymerase (NS5), ZINC ION 著者 Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2006-06-18 公開日 2007-02-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
2HFZ	Crystal structure of RNA dependent RNA polymerase domain from West Nile virus 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase(NS5), ZINC ION 著者 Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2006-06-26 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
2HWK	Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain 分子名称: FORMIC ACID, helicase nsP2 著者 Russo, A.T, White, M.A, Watowich, S.J. 登録日 2006-08-01 公開日 2006-09-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 The Crystal Structure of the Venezuelan Equine Encephalitis Alphavirus nsP2 Protease. Structure, 14, 2006
2HWH	HCV NS5B allosteric inhibitor complex 分子名称: 4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE, RNA-directed RNA polymerase (NS5B) (p68) 著者 Yao, N. 登録日 2006-08-01 公開日 2006-11-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2HWI	HCV NS5B allosteric inhibitor complex 分子名称: (2S)-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)(4-FLUOROPHENYL)ACETIC ACID, RNA-directed RNA polymerase (NS5B) (p68) 著者 Yao, N. 登録日 2006-08-01 公開日 2006-11-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2I1R	Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure 分子名称: (5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE, RNA-directed RNA polymerase (NS5B) (P68) 著者 Yao, N, Yan, S. 登録日 2006-08-14 公開日 2006-10-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure. Bioorg.Med.Chem.Lett., 17, 2007

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