2FVC

Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone

Summary for 2FVC

• Entry DOI: 10.2210/pdb2fvc/pdb
• Descriptor: polyprotein, 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one (3 entities in total)
• Functional Keywords: hcv polymerase, thiadiazin inhibitor, transferase
• Biological source: Hepatitis C virus subtype 1b
• Total number of polymer chains: 2
• Total formula weight: 125688.11

Authors

Concha, N.O.,Wonacott, A.,Singh, O. (deposition date: 2006-01-30, release date: 2007-01-16, Last modification date: 2023-08-30)

• Primary citation: Tedesco, R.,Shaw, A.N.,Bambal, R.,Chai, D.,Concha, N.O.,Darcy, M.G.,Dhanak, D.,Fitch, D.M.,Gates, A.,Gerhardt, W.G.,Halegoua, D.L.,Han, C.,Hofmann, G.A.,Johnston, V.K.,Kaura, A.C.,Liu, N.,Keenan, R.M.,Lin-Goerke, J.,Sarisky, R.T.,Wiggall, K.J.,Zimmerman, M.N.,Duffy, K.J.; 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.; J.Med.Chem., 49:971-983, 2006; PubMed: 16451063; DOI: 10.1021/jm050855s

Experimental method

X-RAY DIFFRACTION (2 Å)