6O5H
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![BU of 6o5h by Molmil](/molmil-images/mine/6o5h) | The effect of modifier structure on the activation of leukotriene A4 hydrolase aminopeptidase activity. | 分子名称: | 4-{4-[(4-methoxyphenyl)methyl]phenyl}-1,3-thiazol-2-amine, Leukotriene A-4 hydrolase, ZINC ION | 著者 | Noble, S.M, Lee, K.H, Paige, M. | 登録日 | 2019-03-03 | 公開日 | 2019-12-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Effect of Modifier Structure on the Activation of Leukotriene A4Hydrolase Aminopeptidase Activity. J.Med.Chem., 62, 2019
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6OIU
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![BU of 6oiu by Molmil](/molmil-images/mine/6oiu) | |
6RQX
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![BU of 6rqx by Molmil](/molmil-images/mine/6rqx) | |
6RYF
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![BU of 6ryf by Molmil](/molmil-images/mine/6ryf) | High-resolution crystal structure of ERAP1 in complex with 15mer phosphinic peptide | 分子名称: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Giastas, P, Stratikos, E. | 登録日 | 2019-06-10 | 公開日 | 2019-12-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1. Proc.Natl.Acad.Sci.USA, 2019
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6SBR
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![BU of 6sbr by Molmil](/molmil-images/mine/6sbr) | The crystal structure of PfA-M1 in complex with 7-amino-1,4-dibromo-5,7,8,9-tetrahydrobenzocyclohepten-6-one | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Salomon, E, Schmitt, M, Mouray, E, McEwen, A.G, Torchy, M, Poussin-Courmontagne, P, Alavi, S, Tarnus, C, Cavarelli, J, Florent, I, Albrecht, S. | 登録日 | 2019-07-22 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation. Bioorg.Chem., 98, 2020
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6SBQ
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![BU of 6sbq by Molmil](/molmil-images/mine/6sbq) | The crystal structure of PfA-M1 in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one | 分子名称: | DI(HYDROXYETHYL)ETHER, M1-family alanyl aminopeptidase, MALONATE ION, ... | 著者 | Salomon, E, Schmitt, M, Mouray, E, McEwen, A.G, Torchy, M, Poussin-Courmontagne, P, Alavi, S, Tarnus, C, Cavarelli, J, Florent, I, Albrecht, S. | 登録日 | 2019-07-22 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation. Bioorg.Chem., 98, 2020
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6KP1
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![BU of 6kp1 by Molmil](/molmil-images/mine/6kp1) | Crystal structure of two domain M1 zinc metallopeptidase E323A mutant bound to L-methionine amino acid | 分子名称: | METHIONINE, SODIUM ION, ZINC ION, ... | 著者 | Agrawal, R, Kumar, A, Kumar, A, Makde, R.D. | 登録日 | 2019-08-13 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase. Int.J.Biol.Macromol., 147, 2020
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6KP0
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![BU of 6kp0 by Molmil](/molmil-images/mine/6kp0) | Crystal structure of two domain M1 zinc metallopeptidase E323A mutant bound to L-arginine | 分子名称: | ARGININE, SODIUM ION, ZINC ION, ... | 著者 | Agrawal, R, Kumar, A, Kumar, A, Makde, R.D. | 登録日 | 2019-08-13 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase. Int.J.Biol.Macromol., 147, 2020
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6KOZ
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![BU of 6koz by Molmil](/molmil-images/mine/6koz) | Crystal structure of two domain M1 zinc metallopeptidase E323 mutant bound to L-Leucine amino acid | 分子名称: | LEUCINE, SODIUM ION, ZINC ION, ... | 著者 | Agrawal, R, Kumar, A, Kumar, A, Makde, R.D. | 登録日 | 2019-08-13 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase. Int.J.Biol.Macromol., 147, 2020
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6KOY
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![BU of 6koy by Molmil](/molmil-images/mine/6koy) | Crystal structure of two domain M1 Zinc metallopeptidase E323A mutant bound to L-tryptophan amino acid | 分子名称: | TRYPTOPHAN, ZINC ION, Zinc metalloprotease | 著者 | Agrawal, R, Kumar, A, Kumar, A, Makde, R.D. | 登録日 | 2019-08-13 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase. Int.J.Biol.Macromol., 147, 2020
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6U7E
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![BU of 6u7e by Molmil](/molmil-images/mine/6u7e) | HCoV-229E RBD Class III in complex with human APN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Tomlinson, A.C.A, Li, Z, Rini, J.M. | 登録日 | 2019-09-02 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
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6U7G
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![BU of 6u7g by Molmil](/molmil-images/mine/6u7g) | HCoV-229E RBD Class V in complex with human APN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Tomlinson, A, Li, Z, Rini, J.M. | 登録日 | 2019-09-02 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
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6U7F
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![BU of 6u7f by Molmil](/molmil-images/mine/6u7f) | HCoV-229E RBD Class IV in complex with human APN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Tomlinson, A.C.A, Li, Z, Rini, J.M. | 登録日 | 2019-09-02 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
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6T6R
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![BU of 6t6r by Molmil](/molmil-images/mine/6t6r) | Human endoplasmic reticulum aminopeptidase 1 (ERAP1) in complex with (4aR,5S,6R,8S,8aR)-5-(2-(Furan-3-yl)ethyl)-8-hydroxy-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid | 分子名称: | (4~{a}~{R},5~{S},6~{R},8~{S},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-8-oxidanyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid, 1,2-ETHANEDIOL, D-MALATE, ... | 著者 | Rowland, P. | 登録日 | 2019-10-18 | 公開日 | 2020-03-18 | 最終更新日 | 2020-04-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation. J.Med.Chem., 63, 2020
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6YDX
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![BU of 6ydx by Molmil](/molmil-images/mine/6ydx) | Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Saridakis, E, Giastas, P, Stratikos, E. | 登録日 | 2020-03-21 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor. Acs Med.Chem.Lett., 11, 2020
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7AV1
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![BU of 7av1 by Molmil](/molmil-images/mine/7av1) | LTA4 hydrolase in complex with fragment2 | 分子名称: | 2-[5-(4-methoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamine, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7AUZ
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![BU of 7auz by Molmil](/molmil-images/mine/7auz) | LTA4 hydrolase in complex with compound LYS006 | 分子名称: | (3~{S})-3-azanyl-4-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7AV0
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![BU of 7av0 by Molmil](/molmil-images/mine/7av0) | LTA4 hydrolase in complex with compound R(13) | 分子名称: | (3~{R})-3-azanyl-4-[5-[4-(4-chloranylphenoxy)phenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7AV2
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![BU of 7av2 by Molmil](/molmil-images/mine/7av2) | LTA4 hydrolase in complex with fragment1 | 分子名称: | (4-phenoxyphenyl)methanol, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7KZE
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![BU of 7kze by Molmil](/molmil-images/mine/7kze) | Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity | 分子名称: | 1-benzyl-4-methoxybenzene, Leukotriene A-4 hydrolase, TRIETHYLENE GLYCOL, ... | 著者 | Lee, K.H, Shim, Y, Paige, M, Noble, S.M. | 登録日 | 2020-12-10 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Substrate-dependent modulation of the leukotriene A 4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation. Sci Rep, 12, 2022
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7LLQ
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![BU of 7llq by Molmil](/molmil-images/mine/7llq) | Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity | 分子名称: | 1-benzyl-4-methoxybenzene, 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, Leukotriene A-4 hydrolase, ... | 著者 | Lee, K.H, Lee, S.H, Shim, Y.M, Paige, M, Noble, S.M. | 登録日 | 2021-02-04 | 公開日 | 2022-06-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Substrate-dependent modulation of the leukotriene A 4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation. Sci Rep, 12, 2022
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7NSK
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![BU of 7nsk by Molmil](/molmil-images/mine/7nsk) | Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand | 分子名称: | (2~{S})-3-(4-hydroxyphenyl)-~{N}-oxidanyl-2-[4-[[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]propanamide, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... | 著者 | Mpakali, A, Giastas, P, Stratikos, E. | 登録日 | 2021-03-08 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Endoplasmic reticulum aminopeptidase 2 in complex with a phosphinic ligand To Be Published
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7NUP
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![BU of 7nup by Molmil](/molmil-images/mine/7nup) | Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand | 分子名称: | (3~{S})-4-(4-hydroxyphenyl)-~{N}-oxidanyl-3-[5-[[(5-phenylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]butanamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Giastas, P, Stratikos, E. | 登録日 | 2021-03-12 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand To Be Published
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7P7P
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![BU of 7p7p by Molmil](/molmil-images/mine/7p7p) | Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide((1R)-1-Amino-3-phenylpropyl){(2S)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino]-2-{[3-(2-hydroxyphenyl)-isoxazol-5-yl]methyl}-3-oxopropyl}phosphinic acid | 分子名称: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Giastas, P, Stratikos, E, Mpakali, A. | 登録日 | 2021-07-20 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13, 2022
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7PFS
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![BU of 7pfs by Molmil](/molmil-images/mine/7pfs) | Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide ((1R)-1-Amino-3-phenylpropyl){2-([1,1:3,1-terphenyl]-5-ylmethyl)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)-amino]-3-oxopropyl}phosphinic acid | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Giastas, P, Stratikos, E, Mpakali, A. | 登録日 | 2021-08-12 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13, 2022
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