6T6R

Human endoplasmic reticulum aminopeptidase 1 (ERAP1) in complex with (4aR,5S,6R,8S,8aR)-5-(2-(Furan-3-yl)ethyl)-8-hydroxy-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid

Summary for 6T6R

Entry DOI	10.2210/pdb6t6r/pdb
Descriptor	Endoplasmic reticulum aminopeptidase 1, ZINC ION, D-MALATE, ... (6 entities in total)
Functional Keywords	erap1, aminopeptidase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	107126.64
Authors	Rowland, P. (deposition date: 2019-10-18, release date: 2020-03-18, Last modification date: 2020-04-08)
Primary citation	Liddle, J.,Hutchinson, J.P.,Kitchen, S.,Rowland, P.,Neu, M.,Cecconie, T.,Holmes, D.S.,Jones, E.,Korczynska, J.,Koumantou, D.,Lea, J.D.,Nickels, L.,Pemberton, M.,Phillipou, A.,Schneck, J.L.,Sheehan, H.,Tinworth, C.P.,Uings, I.,Wojno-Picon, J.,Young, R.J.,Stratikos, E. Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation. J.Med.Chem., 63:3348-3358, 2020 Cited by PubMed: 32109056 DOI: 10.1021/acs.jmedchem.9b02123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation