6T6R
Human endoplasmic reticulum aminopeptidase 1 (ERAP1) in complex with (4aR,5S,6R,8S,8aR)-5-(2-(Furan-3-yl)ethyl)-8-hydroxy-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endoplasmic reticulum aminopeptidase 1 | polymer | 922 | 105343.4 | 1 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | D-MALATE | non-polymer | 134.1 | 2 | Chemie (MLT) PubChem (525) PubChem (92824) PubChem (222656) | |||
| 4 | E, F, G, H, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 18 | Chemie (EDO) | |||
| 5 | W (A) | (4~{a}~{R},5~{S},6~{R},8~{S},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-8-oxidanyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid | non-polymer | 332.4 | 1 | Chemie (MNZ) PubChem (7330548) PubChem (9996881) PubChem (26451326) PubChem (44631021) PubChem (45359865) PubChem (51693782) PubChem (51693778) PubChem (51693780) PubChem (51693784) PubChem (7330550) PubChem (162988923) PubChem (124870801) PubChem (124870802) PubChem (124870803) PubChem (162988919) PubChem (162988920) PubChem (162988921) PubChem (162988922) PubChem (162988924) | |||
| 6 | X (A) | water | water | 18.0 | 945 | Chemie (HOH) |
Sequence modifications
A: 1 - 941 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| Gln 70 | Asn 70 | engineered mutation |
| Gln 154 | Asn 154 | engineered mutation |
| Gln 414 | Asn 414 | engineered mutation |
| Gly 511 | Cys 486 | conflict |
| - | Pro 487 | deletion |
| - | Thr 488 | deletion |
| - | Asp 489 | deletion |
| - | Gly 490 | deletion |
| - | Val 491 | deletion |
| - | Lys 492 | deletion |
| - | Gly 493 | deletion |
| - | Met 494 | deletion |
| - | Asp 495 | deletion |
| - | Gly 496 | deletion |
| - | Phe 497 | deletion |
| - | Cys 498 | deletion |
| - | Ser 499 | deletion |
| - | Arg 500 | deletion |
| - | Ser 501 | deletion |
| - | Gln 502 | deletion |
| - | His 503 | deletion |
| - | Ser 504 | deletion |
| - | Ser 505 | deletion |
| - | Ser 506 | deletion |
| - | Ser 507 | deletion |
| - | Ser 508 | deletion |
| - | His 509 | deletion |
| - | Trp 510 | deletion |
| - | His 511 | deletion |
| Ser 512 | Gln 512 | conflict |
| Gly 513 | Glu 513 | conflict |
| Gln 760 | Asn 760 | engineered mutation |
| Glu 942 | - | expression tag |
| Asn 943 | - | expression tag |
| Leu 944 | - | expression tag |
| Tyr 945 | - | expression tag |
| Phe 946 | - | expression tag |
| Gln 947 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 105343.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 1783.2 | |
| All* | Total formula weight | 107126.6 |
