6T6R
Human endoplasmic reticulum aminopeptidase 1 (ERAP1) in complex with (4aR,5S,6R,8S,8aR)-5-(2-(Furan-3-yl)ethyl)-8-hydroxy-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Endoplasmic reticulum aminopeptidase 1 | polymer | 922 | 105343.4 | 1 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | Homo sapiens (Human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | D-MALATE | non-polymer | 134.1 | 2 | Chemie (MLT) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 18 | Chemie (EDO) | |||
| 5 | A | (4~{a}~{R},5~{S},6~{R},8~{S},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-8-oxidanyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid | non-polymer | 332.4 | 1 | Chemie (MNZ) | |||
| 6 | water | water | 18.0 | 945 | Chemie (HOH) |
Sequence modifications
A: 1 - 941 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| Gln 70 | Asn 70 | engineered mutation |
| Gln 154 | Asn 154 | engineered mutation |
| Gln 414 | Asn 414 | engineered mutation |
| Gly 511 | Cys 486 | conflict |
| - | Pro 487 | deletion |
| - | Thr 488 | deletion |
| - | Asp 489 | deletion |
| - | Gly 490 | deletion |
| - | Val 491 | deletion |
| - | Lys 492 | deletion |
| - | Gly 493 | deletion |
| - | Met 494 | deletion |
| - | Asp 495 | deletion |
| - | Gly 496 | deletion |
| - | Phe 497 | deletion |
| - | Cys 498 | deletion |
| - | Ser 499 | deletion |
| - | Arg 500 | deletion |
| - | Ser 501 | deletion |
| - | Gln 502 | deletion |
| - | His 503 | deletion |
| - | Ser 504 | deletion |
| - | Ser 505 | deletion |
| - | Ser 506 | deletion |
| - | Ser 507 | deletion |
| - | Ser 508 | deletion |
| - | His 509 | deletion |
| - | Trp 510 | deletion |
| - | His 511 | deletion |
| Ser 512 | Gln 512 | conflict |
| Gly 513 | Glu 513 | conflict |
| Gln 760 | Asn 760 | engineered mutation |
| Glu 942 | - | expression tag |
| Asn 943 | - | expression tag |
| Leu 944 | - | expression tag |
| Tyr 945 | - | expression tag |
| Phe 946 | - | expression tag |
| Gln 947 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 105343.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 1783.2 | |
| All* | Total formula weight | 107126.6 |
