4MAN
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![BU of 4man by Molmil](/molmil-images/mine/4man) | Bcl_2-Navitoclax Analog (with Indole) Complex | 分子名称: | 4-[4-({4'-chloro-3-[2-(dimethylamino)ethoxy]biphenyl-2-yl}methyl)piperazin-1-yl]-2-(1H-indol-5-yloxy)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)benzamide, Apoptosis regulator Bcl-2 | 著者 | Park, C.H. | 登録日 | 2013-08-16 | 公開日 | 2014-01-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19, 2013
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4K5B
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![BU of 4k5b by Molmil](/molmil-images/mine/4k5b) | Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W | 分子名称: | Apoptosis regulator BCL-W, Bcl-2-like protein 2 | 著者 | Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. | 登録日 | 2013-04-14 | 公開日 | 2014-04-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
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1PQ0
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![BU of 1pq0 by Molmil](/molmil-images/mine/1pq0) | Crystal structure of mouse Bcl-xl | 分子名称: | Apoptosis regulator Bcl-X | 著者 | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | 登録日 | 2003-06-17 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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1PQ1
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![BU of 1pq1 by Molmil](/molmil-images/mine/1pq1) | Crystal structure of Bcl-xl/Bim | 分子名称: | Apoptosis regulator Bcl-X, BCL2-like protein 11 | 著者 | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | 登録日 | 2003-06-17 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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7JGV
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![BU of 7jgv by Molmil](/molmil-images/mine/7jgv) | CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2 | 分子名称: | 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1 | 著者 | Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F. | 登録日 | 2020-07-19 | 公開日 | 2021-02-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
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7JGW
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![BU of 7jgw by Molmil](/molmil-images/mine/7jgw) | Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1 | 分子名称: | 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1 | 著者 | Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F. | 登録日 | 2020-07-19 | 公開日 | 2021-02-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
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3QKD
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![BU of 3qkd by Molmil](/molmil-images/mine/3qkd) | Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor | 分子名称: | (R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide, Bcl-2-like protein 1, CHLORIDE ION, ... | 著者 | Czabotar, P.E, Smith, B.J. | 登録日 | 2011-01-31 | 公開日 | 2011-04-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. J.Med.Chem., 54, 2011
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1R2G
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![BU of 1r2g by Molmil](/molmil-images/mine/1r2g) | Human Bcl-XL containing a Phe to Trp mutation at position 97 | 分子名称: | Apoptosis regulator Bcl-X | 著者 | O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M. | 登録日 | 2003-09-26 | 公開日 | 2004-02-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Bcl-XL mutations suppress cellular sensitivity to antimycin A. J.Biol.Chem., 279, 2004
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1R2E
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![BU of 1r2e by Molmil](/molmil-images/mine/1r2e) | Human Bcl-XL containing a Glu to Leu mutation at position 92 | 分子名称: | Apoptosis regulator Bcl-X | 著者 | O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M. | 登録日 | 2003-09-26 | 公開日 | 2004-02-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Bcl-XL mutations suppress cellular sensitivity to antimycin A. J.Biol.Chem., 279, 2004
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4HNJ
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![BU of 4hnj by Molmil](/molmil-images/mine/4hnj) | |
3R85
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![BU of 3r85 by Molmil](/molmil-images/mine/3r85) | Crystal structure of human SOUL BH3 domain in complex with Bcl-xL | 分子名称: | Bcl-2-like protein 1, Heme-binding protein 2, SULFATE ION | 著者 | Ambrosi, E.K, Capaldi, S, Bovi, M, Saccomani, G, Perduca, M, Monaco, H.L. | 登録日 | 2011-03-23 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. Biochem.J., 438, 2011
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1TY4
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![BU of 1ty4 by Molmil](/molmil-images/mine/1ty4) | Crystal structure of a CED-9/EGL-1 complex | 分子名称: | Apoptosis regulator ced-9, EGg Laying defective EGL-1, programmed cell death activator | 著者 | Yan, N, Gu, L, Kokel, D, Xue, D, Shi, Y. | 登録日 | 2004-07-07 | 公開日 | 2004-09-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4 Mol.Cell, 15, 2004
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6BF2
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3SPF
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![BU of 3spf by Molmil](/molmil-images/mine/3spf) | Crystal Structure of Bcl-xL bound to BM501 | 分子名称: | 4-(4-chlorophenyl)-1-[(3S)-3,4-dihydroxybutyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-phenyl-1H-pyrrole-2-carboxamide, Bcl-2-like protein 1, GLYCEROL | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2011-07-01 | 公開日 | 2012-06-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. J.Med.Chem., 55, 2012
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1R2I
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![BU of 1r2i by Molmil](/molmil-images/mine/1r2i) | Human Bcl-XL containing a Phe to Leu mutation at position 146 | 分子名称: | Apoptosis regulator Bcl-X | 著者 | O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M. | 登録日 | 2003-09-26 | 公開日 | 2004-02-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Bcl-XL mutations suppress cellular sensitivity to antimycin A. J.Biol.Chem., 279, 2004
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1R2H
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![BU of 1r2h by Molmil](/molmil-images/mine/1r2h) | Human Bcl-XL containing an Ala to Leu mutation at position 142 | 分子名称: | Apoptosis regulator Bcl-X | 著者 | O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M. | 登録日 | 2003-09-26 | 公開日 | 2004-02-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Bcl-XL mutations suppress cellular sensitivity to antimycin A. J.Biol.Chem., 279, 2004
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1R2D
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![BU of 1r2d by Molmil](/molmil-images/mine/1r2d) | Structure of Human Bcl-XL at 1.95 Angstroms | 分子名称: | Apoptosis regulator Bcl-X | 著者 | O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M. | 登録日 | 2003-09-26 | 公開日 | 2004-02-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Bcl-XL mutations suppress cellular sensitivity to antimycin A. J.Biol.Chem., 279, 2004
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7LHB
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![BU of 7lhb by Molmil](/molmil-images/mine/7lhb) | Crystal structure of Bcl-2 in complex with prodrug ABBV-167 | 分子名称: | Apoptosis regulator Bcl-2, Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester | 著者 | Judge, R.A, Salem, A.H. | 登録日 | 2021-01-21 | 公開日 | 2021-04-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.068 Å) | 主引用文献 | Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol.Cancer Ther., 20, 2021
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4IEH
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3SP7
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![BU of 3sp7 by Molmil](/molmil-images/mine/3sp7) | Crystal Structure of Bcl-xL bound to BM903 | 分子名称: | 5-(4-chlorophenyl)-4-{3-[4-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]amino}phenyl)piperazin-1-yl]phenyl}-1,2-dimethyl-1H-pyrrole-3-carboxylic acid, ACETATE ION, Bcl-2-like protein 1, ... | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2011-07-01 | 公開日 | 2012-07-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors To be Published
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7LH7
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![BU of 7lh7 by Molmil](/molmil-images/mine/7lh7) | Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor | 分子名称: | Bcl-2-like protein 1, N-(1,3-benzothiazol-2-yl)-2-(4-{[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]carbamoyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide | 著者 | Judge, R.A, Tao, Z. | 登録日 | 2021-01-21 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.409 Å) | 主引用文献 | Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor ACS Medicinal Chemistry Letters, 12, 2021
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6QZ7
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![BU of 6qz7 by Molmil](/molmil-images/mine/6qz7) | Structure of MBP-Mcl-1 in complex with compound 8b | 分子名称: | (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION, ... | 著者 | Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. | 登録日 | 2019-03-11 | 公開日 | 2019-08-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J.Med.Chem., 62, 2019
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6QXJ
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![BU of 6qxj by Molmil](/molmil-images/mine/6qxj) | Structure of MBP-Mcl-1 in complex with compound 6a | 分子名称: | (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]amino]propanoic acid, Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION, ... | 著者 | Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. | 登録日 | 2019-03-07 | 公開日 | 2019-08-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J.Med.Chem., 62, 2019
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7Y99
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![BU of 7y99 by Molmil](/molmil-images/mine/7y99) | Crystal Structure Analysis of cp2 bound BCLxl | 分子名称: | Bcl-2-like protein 1, CP2 peptide, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | 登録日 | 2022-06-24 | 公開日 | 2023-09-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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2YQ7
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![BU of 2yq7 by Molmil](/molmil-images/mine/2yq7) | Structure of Bcl-xL bound to BimLOCK | 分子名称: | BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL | 著者 | Smith, B.J, Czabotar, P.E. | 登録日 | 2012-11-06 | 公開日 | 2012-11-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
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