6QZ7
Structure of MBP-Mcl-1 in complex with compound 8b
Summary for 6QZ7
Entry DOI | 10.2210/pdb6qz7/pdb |
Related | 6qxj 6qyk 6qyl 6qyn 6qyo 6qyp 6qz5 6qz6 |
Related PRD ID | PRD_900001 |
Descriptor | Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, ... (5 entities in total) |
Functional Keywords | apoptosis-inhibitor complex, mcl1, small molecule inhibitor, mbp, apoptosis |
Biological source | Escherichia coli More |
Total number of polymer chains | 1 |
Total formula weight | 58033.69 |
Authors | Dokurno, P.,Szlavik, Z.,Ondi, L.,Csekei, M.,Paczal, A.,Szabo, Z.B.,Radics, G.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Hubbard, R.E.,Pedder, C.,Surgenor, A.E.,Smith, J.,Robertson, A.,LeToumelin-Braizat, G.,Cauquil, N.,Zarka, M.,Demarles, D.,Perron-Sierra, F.,Geneste, O.,Kotschy, A. (deposition date: 2019-03-11, release date: 2019-08-07, Last modification date: 2024-01-24) |
Primary citation | Szlavik, Z.,Ondi, L.,Csekei, M.,Paczal, A.,Szabo, Z.B.,Radics, G.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Hubbard, R.E.,Pedder, C.,Dokurno, P.,Surgenor, A.,Smith, J.,Robertson, A.,LeToumelin-Braizat, G.,Cauquil, N.,Zarka, M.,Demarles, D.,Perron-Sierra, F.,Claperon, A.,Colland, F.,Geneste, O.,Kotschy, A. Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J.Med.Chem., 62:6913-6924, 2019 Cited by PubMed: 31339316DOI: 10.1021/acs.jmedchem.9b00134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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