1R2H

Human Bcl-XL containing an Ala to Leu mutation at position 142

Summary for 1R2H

Entry DOI	10.2210/pdb1r2h/pdb
Related	1MAZ 1R2D 1R2E 1R2G 1R2I
Descriptor	Apoptosis regulator Bcl-X (2 entities in total)
Functional Keywords	apoptosis, monomeric, alpha-helical, mutation
Biological source	Homo sapiens (human)
Cellular location	Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817
Total number of polymer chains	1
Total formula weight	24649.02
Authors	O'Neill, J.W.,Manion, M.K.,Giedt, C.D.,Kim, K.M.,Zhang, K.Y.,Hockenbery, D.M. (deposition date: 2003-09-26, release date: 2004-02-03, Last modification date: 2023-08-23)
Primary citation	Manion, M.K.,O'Neill, J.W.,Giedt, C.D.,Kim, K.M.,Zhang, K.Y.,Hockenbery, D.M. Bcl-XL mutations suppress cellular sensitivity to antimycin A. J.Biol.Chem., 279:2159-2165, 2004 Cited by PubMed: 14534311 DOI: 10.1074/jbc.M306021200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation