6QTQ
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6QTX
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6QTU
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6QTV
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6UFX
| WD repeat-containing protein 5 complexed with N-[(3,5-dimethoxyphenyl)methyl]-4'-fluoro-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-2'-methyl[1,1'-biphenyl]-3-carboxamide (compound 13) | 分子名称: | N-[(3,5-dimethoxyphenyl)methyl]-4'-fluoro-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-2'-methyl[1,1'-biphenyl]-3-carboxamide, WD repeat-containing protein 5 | 著者 | Rietz, T.A, Fesik, S.W, Zhao, B. | 登録日 | 2019-09-25 | 公開日 | 2020-01-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.015 Å) | 主引用文献 | Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J.Med.Chem., 63, 2020
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6UCS
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6U5Y
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6UIF
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6UIK
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6UJH
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6U5M
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6U8B
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6U6W
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6U8O
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6U8L
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6UJ4
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6UJL
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6UOZ
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6V3X
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6V3Y
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6UJJ
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6UHZ
| WDR5 in complex with Myc site fragment inhibitor | 分子名称: | 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 | 著者 | Wang, F, Fesik, S.w. | 登録日 | 2019-09-29 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.258 Å) | 主引用文献 | Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
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6UHY
| WDR5 in complex with Myc site fragment inhibitor | 分子名称: | 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5 | 著者 | Wang, F, Fesik, S.W. | 登録日 | 2019-09-29 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
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6U80
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6W7F
| Structure of EED bound to inhibitor 5285 | 分子名称: | 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, GLYCEROL, Polycomb protein EED | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2020-03-19 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63, 2020
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