5DGN
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5DGM
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5DGS
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5DIQ
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![BU of 5diq by Molmil](/molmil-images/mine/5diq) | Crystal structure of human FPPS in complex with salicylic acid derivative 3a | 分子名称: | 2-(naphthalen-1-ylmethoxy)benzoic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... | 著者 | Rondeau, J.M, Bourgier, E, Lehmann, S. | 登録日 | 2015-09-01 | 公開日 | 2015-09-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
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5DJP
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5DJV
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5DJR
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![BU of 5djr by Molmil](/molmil-images/mine/5djr) | Crystal structure of human FPPS in complex with biaryl compound 6 | 分子名称: | 1H,1'H-4,4'-biindole-2-carboxylic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... | 著者 | Rondeau, J.M, Bourgier, E, Lehmann, S. | 登録日 | 2015-09-02 | 公開日 | 2015-09-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
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5E8H
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![BU of 5e8h by Molmil](/molmil-images/mine/5e8h) | Crystal structure of geranylfarnesyl pyrophosphate synthases 2 from Arabidopsis thaliana | 分子名称: | Geranylgeranyl pyrophosphate synthase 3, chloroplastic | 著者 | Wang, C, Chen, Q, Wang, G, Zhang, P. | 登録日 | 2015-10-14 | 公開日 | 2015-11-11 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant, 9, 2016
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5E8K
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![BU of 5e8k by Molmil](/molmil-images/mine/5e8k) | Crystal structure of polyprenyl pyrophosphate synthase 2 from Arabidopsis thaliana | 分子名称: | Geranylgeranyl pyrophosphate synthase 10, mitochondrial | 著者 | Wang, C, Chen, Q, Fan, D, Li, J, Wang, G, Zhang, P. | 登録日 | 2015-10-14 | 公開日 | 2015-11-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.028 Å) | 主引用文献 | Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant, 9, 2016
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5E8L
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![BU of 5e8l by Molmil](/molmil-images/mine/5e8l) | Crystal structure of geranylgeranyl pyrophosphate synthase 11 from Arabidopsis thaliana | 分子名称: | Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic | 著者 | Wang, C, Chen, Q, Fan, D, Li, J, Wang, G, Zhang, P. | 登録日 | 2015-10-14 | 公開日 | 2015-11-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.807 Å) | 主引用文献 | Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant, 9, 2016
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5ERN
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5ERO
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5H9D
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![BU of 5h9d by Molmil](/molmil-images/mine/5h9d) | Crystal structure of Heptaprenyl Diphosphate Synthase from Staphylococcus aureus | 分子名称: | C-terminal peptide from Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 family protein, Farnesyl pyrophosphate synthetase, Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 family protein, ... | 著者 | Wei, H.L, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T. | 登録日 | 2015-12-28 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase ChemMedChem, 11, 2016
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5HN7
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5HNA
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5HN8
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![BU of 5hn8 by Molmil](/molmil-images/mine/5hn8) | Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1182 | 分子名称: | 2-{[3-hydroxy-5-(octyloxy)benzyl]sulfanyl}benzoic acid, Farnesyl pyrophosphate synthase, putative, ... | 著者 | Liu, Y.-L, Zhang, Y, Oldfield, E. | 登録日 | 2016-01-18 | 公開日 | 2016-09-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry, 55, 2016
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5HN9
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5JA0
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![BU of 5ja0 by Molmil](/molmil-images/mine/5ja0) | Crystal structure of human FPPS with allosterically bound FPP | 分子名称: | FARNESYL DIPHOSPHATE, Farnesyl pyrophosphate synthase, PHOSPHATE ION | 著者 | Park, J, Zielinski, M, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-04-11 | 公開日 | 2017-01-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nat Commun, 8, 2017
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5JFQ
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![BU of 5jfq by Molmil](/molmil-images/mine/5jfq) | Geranylgeranyl Pyrophosphate Synthetase from archaeon Geoglobus acetivorans | 分子名称: | Geranylgeranyl Pyrophosphate Synthetase | 著者 | Petrova, T, Boyko, K.M, Nikolaeva, A.Y, Stekhanova, T.N, Mardanov, A.V, Rakitin, A.L, Ravin, N.V, Popov, V.O. | 登録日 | 2016-04-19 | 公開日 | 2017-05-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans. Extremophiles, 22, 2018
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5JUZ
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![BU of 5juz by Molmil](/molmil-images/mine/5juz) | Crystal structure of human FPPS in complex with an allosteric inhibitor CL-06-057 | 分子名称: | CHLORIDE ION, Farnesyl pyrophosphate synthase, [(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid | 著者 | Park, J, Magder, A, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-05-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5JV2
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![BU of 5jv2 by Molmil](/molmil-images/mine/5jv2) | Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-055 | 分子名称: | CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ... | 著者 | Park, J, Magder, A, Tsakos, M, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-05-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5JV0
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![BU of 5jv0 by Molmil](/molmil-images/mine/5jv0) | Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038 | 分子名称: | Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid | 著者 | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-05-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5JV1
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![BU of 5jv1 by Molmil](/molmil-images/mine/5jv1) | Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066 | 分子名称: | Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid | 著者 | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-05-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5KSX
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![BU of 5ksx by Molmil](/molmil-images/mine/5ksx) | Crystal structure of human FPPS in complex with an allosteric inhibitor AM-02-072 | 分子名称: | Farnesyl pyrophosphate synthase, PHOSPHATE ION, [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid | 著者 | Park, J, Matralis, A, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-07-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5XN6
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![BU of 5xn6 by Molmil](/molmil-images/mine/5xn6) | Heterodimer crystal structure of geranylgeranyl diphosphate synthases 1 with GGPPS Recruiting Protein(OsGRP) from Oryza sativa | 分子名称: | Os02g0668100 protein, Os07g0580900 protein | 著者 | Wang, C, Zhou, F, Lu, S, Zhang, P. | 登録日 | 2017-05-18 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.598 Å) | 主引用文献 | A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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