PDB: 66311 件ウェブページステータス検索Chemie searchBIRD

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5NGV	CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM 分子名称: Activin receptor type-2B, TETRAETHYLENE GLYCOL, anti-human ActRIIB mAb BYM338 heavy-chain, ... 著者 Rondeau, J.-M, Lehmann, S. 登録日 2017-03-20 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NJB	E. coli Microcin-processing metalloprotease TldD/E with actinonin bound 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACTINONIN, ... 著者 Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2017-03-28 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure, 25, 2017
5NJF	E. coli Microcin-processing metalloprotease TldD/E (TldD H262A mutant) with pentapeptide bound 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ALA-ALA-ALA-ALA-ALA, ... 著者 Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2017-03-28 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure, 25, 2017
5NJC	E. coli Microcin-processing metalloprotease TldD/E (TldD E263A mutant) with hexapeptide bound 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Metalloprotease PmbA, ... 著者 Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2017-03-28 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure, 25, 2017
1GUE	SENSORY RHODOPSIN II 分子名称: CHLORIDE ION, RETINAL, SENSORY RHODOPSIN II 著者 Edman, K, Royant, A, Nollert, P, Maxwell, C.A, Pebay-Peyroula, E, Navarro, J, Neutze, R, Landau, E.M. 登録日 2002-01-24 公開日 2002-04-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor Structure, 10, 2002
1GU8	SENSORY RHODOPSIN II 分子名称: CHLORIDE ION, RETINAL, SENSORY RHODOPSIN II 著者 Edman, K, Royant, A, Nollert, P, Maxwell, C.A, Pebay-Peyroula, E, Navarro, J, Neutze, R, Landau, E.M. 登録日 2002-01-24 公開日 2002-04-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor Structure, 10, 2002
6ARZ	Structure of a phage anti-CRISPR protein 分子名称: BROMIDE ION, GLYCEROL, TETRAETHYLENE GLYCOL, ... 著者 Calmettes, C, Shah, M, Pawluk, A, Davidson, A.R, Maxwell, K.L, Moraes, T.F. 登録日 2017-08-23 公開日 2018-08-29 最終更新日 2019-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein. MBio, 8, 2017
6GOS	E. coli Microcin synthetase McbBCD complex with pro-MccB17 bound 分子名称: 1,2-ETHANEDIOL, Bacteriocin microcin B17, CHLORIDE ION, ... 著者 Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2018-06-04 公開日 2019-01-30 最終更新日 2019-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
5HJS	Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease 分子名称: 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, Nuclear receptor coactivator 1, Oxysterols receptor LXR-alpha, ... 著者 Parthasarathy, G, Klein, D. 登録日 2016-01-13 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem., 59, 2016
6GRH	E. coli Microcin synthetase McbBCD complex with truncated pro-MccB17 bound 分子名称: 1,2-ETHANEDIOL, Bacteriocin microcin B17, CHLORIDE ION, ... 著者 Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2018-06-11 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
5HJP	Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease 分子名称: 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, DI(HYDROXYETHYL)ETHER, Oxysterols receptor LXR-beta, ... 著者 Parthasarathy, G, Klein, D. 登録日 2016-01-13 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem., 59, 2016
4NK3	Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655 分子名称: (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase 著者 Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N. 登録日 2013-11-12 公開日 2014-02-19 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin(). Bioorg.Med.Chem.Lett., 24, 2014
4CKK	Apo structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit 分子名称: DNA GYRASE SUBUNIT A 著者 Hearnshaw, S.J, Edwards, M.J, Stevenson, C.E.M, Lawson, D.M, Maxwell, A. 登録日 2014-01-07 公開日 2014-03-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition. J.Mol.Biol., 426, 2014
4CKL	Structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit with simocyclinone D8 bound 分子名称: DNA GYRASE SUBUNIT A, SIMOCYCLINONE D8 著者 Hearnshaw, S.J, Edwards, M.J, Stevenson, C.E.M, Lawson, D.M, Maxwell, A. 登録日 2014-01-07 公開日 2014-03-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition. J.Mol.Biol., 426, 2014
1LQB	Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex 分子名称: Elongin B, Elongin C, Hypoxia-inducible factor 1 ALPHA, ... 著者 Hon, W.C, Wilson, M.I, Harlos, K, Claridge, T.D, Schofield, C.J, Pugh, C.W, Maxwell, P.H, Ratcliffe, P.J, Stuart, D.I, Jones, E.Y. 登録日 2002-05-09 公開日 2002-07-03 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature, 417, 2002
2LSM	Solution structure of gpFI C-terminal domain 分子名称: DNA-packaging protein FI 著者 Popovic, A, Wu, B, Edwards, A.M, Davidson, A.R, Maxwell, K.L. 登録日 2012-05-02 公開日 2012-07-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural and biochemical characterization of phage lambda FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity. J.Biol.Chem., 287, 2012
6F8J	Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-(1H-pyrazol-1-yl)-N-(pyridin-3-yl)pyridine-3-carboxamide 分子名称: 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B 著者 Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. 登録日 2017-12-13 公開日 2019-06-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
6F96	Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide 分子名称: 6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B 著者 Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. 登録日 2017-12-14 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
6F86	Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide 分子名称: 4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B 著者 Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. 登録日 2017-12-12 公開日 2019-06-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
6F94	Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(3-methyphenyl)amino]-N-(3-methyphenyl)pyridine-3-carboxamide 分子名称: 6-(ethylcarbamoylamino)-~{N}-(3-methylphenyl)-4-[(3-methylphenyl)amino]pyridine-3-carboxamide, DNA gyrase subunit B 著者 Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. 登録日 2017-12-14 公開日 2019-06-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
6FQM	3.06A COMPLEX OF S.AUREUS GYRASE with imidazopyrazinone T1 AND DNA 分子名称: 7-[(3~{S})-3-azanylpyrrolidin-1-yl]-5-cyclopropyl-8-fluoranyl-imidazo[1,2-a]quinoxalin-4-one, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*T)-3'), DNA gyrase subunit A, ... 著者 Bax, B.D, Germe, T, Basque, E, Maxwell, A. 登録日 2018-02-14 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46, 2018
6FQV	2.60A BINARY COMPLEX OF S.AUREUS GYRASE with UNCLEAVED DNA 分子名称: DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*T)-3'), DNA gyrase subunit A, DNA gyrase subunit B,DNA gyrase subunit B, ... 著者 Bax, B.D, Germe, T, Basque, E, Maxwell, A. 登録日 2018-02-14 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46, 2018
6FQS	3.11A complex of S.Aureus gyrase with imidazopyrazinone T3 and DNA 分子名称: 5-cyclopropyl-8-fluoranyl-7-pyridin-4-yl-imidazo[1,2-a]quinoxalin-4-one, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*TP*T)-3'), DNA gyrase subunit A, ... 著者 Bax, B.D, Germe, T, Basque, E, Maxwell, A. 登録日 2018-02-14 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46, 2018
6GRG	E. coli Microcin synthetase McbBCD complex with pro-MccB17, ADP and phosphate bound 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2018-06-11 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
6GRI	E. coli Microcin synthetase McbBCD complex 分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, Microcin B17-processing protein McbB, ... 著者 Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2018-06-11 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019

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