6FQV

2.60A BINARY COMPLEX OF S.AUREUS GYRASE with UNCLEAVED DNA

Summary for 6FQV

• Entry DOI: 10.2210/pdb6fqv/pdb
• Related: 5CDR
• Descriptor: DNA gyrase subunit A, DNA gyrase subunit B,DNA gyrase subunit B, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*T)-3'), ... (7 entities in total)
• Functional Keywords: type iia topoisomerase, antibacterial, inhibitor, isomerase
• Biological source: Staphylococcus aureus (strain N315); More
• Cellular location: Cytoplasm : Q99XG5 P66937
• Total number of polymer chains: 12
• Total formula weight: 338427.01

Authors

Bax, B.D.,Germe, T.,Basque, E.,Maxwell, A. (deposition date: 2018-02-14, release date: 2018-04-04, Last modification date: 2024-01-17)

• Primary citation: Germe, T.,Voros, J.,Jeannot, F.,Taillier, T.,Stavenger, R.A.,Bacque, E.,Maxwell, A.,Bax, B.D.; A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.; Nucleic Acids Res., 46:4114-4128, 2018; PubMed: 29538767; DOI: 10.1093/nar/gky181

Experimental method

X-RAY DIFFRACTION (2.6 Å)