6FQV

2.60A BINARY COMPLEX OF S.AUREUS GYRASE with UNCLEAVED DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change
R	0003677	molecular_function	DNA binding
R	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
R	0005524	molecular_function	ATP binding
R	0006259	biological_process	DNA metabolic process
R	0006265	biological_process	DNA topological change
S	0003677	molecular_function	DNA binding
S	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
S	0005524	molecular_function	ATP binding
S	0006265	biological_process	DNA topological change
T	0003677	molecular_function	DNA binding
T	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
T	0005524	molecular_function	ATP binding
T	0006259	biological_process	DNA metabolic process
T	0006265	biological_process	DNA topological change
U	0003677	molecular_function	DNA binding
U	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
U	0005524	molecular_function	ATP binding
U	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 501

Chain	Residue
A	PRO44
A	ARG47
A	ARG48
A	ILE147
A	PRO157
A	HOH616

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 502

Chain	Residue
A	ARG429
A	ARG432
C	ARG429

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL C 501

Chain	Residue
C	PRO44
C	ARG47
C	ARG48
C	SER158
C	HOH639

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL E 101

Chain	Residue
E	DT6
F	DT14
F	DA15

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL F 101

Chain	Residue
E	DT14
F	DC4
F	DG5

---

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL R 501

Chain	Residue
R	PRO44
R	ARG47
R	PRO157
R	HOH614

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL R 502

Chain	Residue
R	ASP96
R	MET113
R	PRO219
R	ARG485

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL R 503

Chain	Residue
R	ASN54
R	GLU55
R	ASN140

---

site_id	AC9
Number of Residues	6
Details	binding site for residue NA R 504

Chain	Residue
R	TYR322
R	LYS323
R	THR325
R	GLN328
R	HOH629
R	HOH667

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL T 501

Chain	Residue
T	PRO44
T	ARG47
T	SER158
T	HOH610
T	HOH631

---

site_id	AD2
Number of Residues	2
Details	binding site for residue GOL T 502

Chain	Residue
T	GLU263
T	ARG485

---

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 T 503

Chain	Residue
R	ARG429
T	ARG429
T	ARG432

---

site_id	AD4
Number of Residues	4
Details	binding site for residue NA T 504

Chain	Residue
T	TYR322
T	LYS323
T	THR325
T	GLN328

---

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL U 701

Chain	Residue
T	ASP24
U	ASP510
U	LYS581
U	LEU642
U	HOH811

---

site_id	AD6
Number of Residues	3
Details	binding site for residue GOL V 101

Chain	Residue
V	DT14
W	DG5
W	DT6

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU433-GLY441

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	456
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---