PDB: 957 件ウェブページステータス検索Chemie searchBIRD

---

7RJ2	Co-crystal structure of lenacapavir bound to Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION, ... 著者 Bester, S.M, Kvaratskhelia, M. 登録日 2021-07-20 公開日 2022-07-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RHN	Co-crystal structure of Q67H mutant of disulfide stabilized HIV-1 CA hexamer and lenacapavir 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION, ... 著者 Bester, S.M, Kvaratskhelia, M. 登録日 2021-07-17 公開日 2022-07-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RHM	Structure of Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer 分子名称: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION 著者 Bester, S.M, Kvaratskhelia, M. 登録日 2021-07-17 公開日 2022-07-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RAO	Structure of M66I mutant of disulfide stabilized HIV-1 CA hexamer 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION 著者 Bester, S.M, Kvaratskhelia, M. 登録日 2021-07-02 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural and mechanistic bases of viral resistance to long-acting HIV-1 capsid inhibitor, Lenacapavir To Be Published
7T13	Hexameric HIV-1 (M-group) CA Q50Y mutant 分子名称: Capsid protein p24 著者 Jacques, D.A, James, L.C. 登録日 2021-12-01 公開日 2022-10-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
7T12	Hexameric HIV-1 (O-group) CA 分子名称: Capsid protein p24 著者 Jacques, D.A, James, L.C. 登録日 2021-12-01 公開日 2022-10-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
7M9F	Structure of the wild-type native full-length HIV-1 capsid protein in complex with ZW-1261 分子名称: HIV-1 capsid protein, IODIDE ION, N-(4-chlorophenyl)-Nalpha-[(5-hydroxy-1H-indol-3-yl)acetyl]-N-methyl-L-phenylalaninamide 著者 Kirby, K.A, Sarafianos, S.G. 登録日 2021-03-31 公開日 2022-04-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular Dynamics Free Energy Simulations Reveal the Mechanism for the Antiviral Resistance of the M66I HIV-1 Capsid Mutation. Viruses, 13, 2021
7MN0	N74D mutant of the HIV-1 capsid protein 分子名称: IODIDE ION, capsid protein 著者 Gres, A.T, Kirby, K.A, Sarafianos, S.G. 登録日 2021-04-30 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 TRIM5alpha Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. Viruses, 14, 2022
7MKC	N74D mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74) 分子名称: IODIDE ION, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE, capsid protein 著者 Kirby, K.A, Sarafianos, S.G. 登録日 2021-04-23 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 TRIM5alpha Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. Viruses, 14, 2022
7NQQ	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(hydroxymethyl)-2,3-dihydroinden-1-yl]ethanamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 O'Reilly, M. 登録日 2021-03-02 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.943 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NQW	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)ethyl]-3~{H}-isoindol-1-one, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 O'Reilly, M. 登録日 2021-03-02 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.775 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7N9V	CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions 分子名称: Capsid protein, Nanobody-GYAR 著者 Tripler, T.N. 登録日 2021-06-18 公開日 2022-06-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions To Be Published
7N9U	CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions 分子名称: Capsid protein, Nanobody 著者 Gerber, E.E, Digianantonio, K.M, Tripler, T.N, Smaga, S.S, Summers, B.J, Xiong, Y. 登録日 2021-06-18 公開日 2022-06-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions To Be Published
7NR3	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethyl]-3~{H}-isoindol-1-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2021-03-02 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NR9	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(2-methoxypyridin-4-yl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A. 登録日 2021-03-03 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NR8	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... 著者 O'Reilly, M, Cleasby, A. 登録日 2021-03-03 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.627 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NR5	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A. 登録日 2021-03-03 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.766 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7MFE	Autoinhibited BRAF:(14-3-3)2 complex with the BRAF RBD resolved 分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, ZINC ION 著者 Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K. 登録日 2021-04-09 公開日 2022-01-26 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13, 2022
7MFF	Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor 分子名称: (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf 著者 Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K. 登録日 2021-04-09 公開日 2022-01-26 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13, 2022
8CL1	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to CPSF6 peptide. 分子名称: Cleavage and polyadenylation specificity factor subunit 6, Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKZ	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Nup153 peptide 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKX	HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKY	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Nup153 peptide 分子名称: Gag polyprotein, Nuclear pore complex protein Nup153 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKV	HIV-1 mature capsid hexamer from CA-IP6 CLPs 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL3	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Sec24C peptide. 分子名称: Gag polyprotein, Protein transport protein Sec24C 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023

<3456789101112131415161718>