7MKC

N74D mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74)

Summary for 7MKC

• Entry DOI: 10.2210/pdb7mkc/pdb
• Related: 7MN0
• Descriptor: capsid protein, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE, IODIDE ION, ... (4 entities in total)
• Functional Keywords: hiv-1 capsid protein, hexmer, ca-targeting antiviral, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 26818.36

Authors

Kirby, K.A.,Sarafianos, S.G. (deposition date: 2021-04-23, release date: 2022-05-04, Last modification date: 2023-10-18)

• Primary citation: Selyutina, A.,Simons, L.M.,Kirby, K.A.,Bulnes-Ramos, A.,Hu, P.,Sarafianos, S.G.,Hultquist, J.F.,Diaz-Griffero, F.; TRIM5alpha Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection.; Viruses, 14:363-, 2022; PubMed: 35215956; DOI: 10.3390/v14020363

Experimental method

X-RAY DIFFRACTION (2.65 Å)